Results 51 to 60 of about 26,150 (274)
Senescence drives non-cell autonomous tumorigenesis in the pituitary gland
Molecular & Cellular Oncology, 2018 Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors.
Jose Mario Gonzalez-Meljem +1 more
doaj +1 more source
The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence
Cancer Management and Research, 2020 Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
doaj
Science-Business eXchange, 2013 German researchers have identified a hypermetabolic phenotype in senescent tumor cells that exerts tumorigenic effects on other cells in the tumor microenvironment. Although small molecule inhibitors of the phenotype improved survival in a mouse model of lymphoma, future studies will need to determine whether the phenotype occurs in primary tumors.
openaire +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
AISA can control the inflammatory facet of SASP
Mechanisms of Ageing and Development, 2020 Senescent cells have been suspected, because of their secretory phenotype (SASP or Senescence Associated Secretory Profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives) monoterpens have been characterized as possessing anti-inflammatory capacities
D’alessio, Patrizia A. +1 more
openaire +4 more sources
(-)-α-Bisabolol inhibits D-Gal-induced HSF cellular senescence in vitro and prevents skin aging in vivo by reducing SASP [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): To study the anti-aging effect of (-)-α-bisabolol ((-)-α-bis) on the skin and preliminarily clarify its mechanism. Materials and Methods: Human skin fibroblasts (HSF) were induced senescence by D-Galactose.
Meixing He +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Environmental Health and Preventive MedicineBackground: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a ...
Kazuyuki Okamura +3 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source