Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases [PDF]
Journal of Oral MicrobiologyBackground Global demographic aging is intensifying the burden of age-related diseases. Cellular senescence and the accompanying senescence-associated secretory phenotype (SASP) act as key drivers of disease progression by mediating chronic inflammation.
Enfang Wu +4 more
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The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
Molecular CancerCellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP).
Qiang Tong
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Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer [PDF]
PeerJBackground Pancreatic cancer (PC) exhibits an extremely poor prognosis due to its high heterogeneity. The senescence-associated secretory phenotype (SASP), a distinct secretory profile displayed by senescent cells, has been increasingly studied. However,
Yuewen Kuang +3 more
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Cationic local composition fluctuations in rapidly cooled nuclear fuel melts
Nuclear Materials and Energy, 2022 During a severe accident in a nuclear reactor, as it occurred in Fukushima Daiichi BWRs in 2011, the so-called “corium” resulting from the thermal fusion of nuclear fuel and interaction with the zircaloy cladding at high temperature (T > 2800 K) can be ...
Mohamed Jizzini +4 more
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Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]
PLoS ONE, 2012 Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
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The Histone Code of Senescence
Cells, 2020 Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage.
Harikrishnareddy Paluvai +2 more
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The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
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COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]
, 2020 COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx +30 more
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Phenomenology and Mind, 2017 There is a prevalent tension within recent cognitive scientific accounts of human selfhood in that either bodily processes or social processes are explanatorily favored at the expense of the other.
Joe Higgins
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Controlling secretion to limit chemoresistance [PDF]
, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
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