Results 11 to 20 of about 22,235 (292)

Senescence and the SASP: many therapeutic avenues [PDF]

Genes & Development, 2020
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-
Birch, J, Gil, J
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Biliary Epithelial Senescence in Liver Disease: There Will Be SASP [PDF]

Frontiers in Molecular Biosciences, 2021
Cellular senescence is a pathophysiological phenomenon in which proliferative cells enter cell cycle arrest following DNA damage and other stress signals. Natural, permanent DNA damage can occur after repetitive cell division; however, acute stress or other injuries can push cells into premature senescence and eventually a senescence-associated ...
Vik Meadows, Leonardo Baiocchi, Debjyoti Kundu, Keisaku Sato, Yessenia Fuentes, Chaodong Wu, Sanjukta Chakraborty, Shannon Glaser, Gianfranco Alpini, Gianfranco Alpini, Lindsey Kennedy, Lindsey Kennedy, Heather Francis, Heather Francis   +13 more
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Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

Oncotarget, 2016
Endothelial cell senescence is characterized by acquisition of senescence-associated secretory phenotype (SASP), able to promote inflammaging and cancer progression. Emerging evidence suggest that preventing SASP development could help to slow the rate of aging and the progression of age-related diseases, including cancer.
Prattichizzo, Francesco, Giuliani, Angelica, Recchioni, Rina, BONAFE', MASSIMILIANO, Marcheselli, Fiorella, DE CAROLIS, SABRINA, Campanati, Anna, Giuliodori, Katia, Rippo, Maria Rita, Brugè, Francesca, Tiano, Luca, Micucci, Carla, Ceriello, Antonio, Offidani, Annamaria, Procopio, Antonio Domenico, Olivieri, Fabiola   +15 more
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SASP – Physiotherapy beyond 100 years of rehabilitation

South African Journal of Physiotherapy
No abstract ...
Witness Mudzi
doaj   +3 more sources

Whole Chromosome Instability induces senescence and promotes SASP [PDF]

Scientific Reports, 2016
Abstract Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To determine the consequences of whole chromosome instability ( W-CIN ) we down-regulated the spindle assembly ...
Andriani, GA, Almeida, VP, Faggioli, F, Mauro, M, Tsai, WL, Santambrogio, L, Maslov, A, Gadina, M, Campisi, J, Vijg, J, Montagna, C   +10 more
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Mitochondrial RNA cytosolic leakage drives the SASP

Nature Communications
Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (
Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P. A. Everts, Gung Lee, Nicholas Pirius, Nuan Han, Eugene Y. Liang, Ana Catarina Franco, Yeaeun Han, Dominik Saul, Eva Nóvoa, Rubén Nogueiras, Patrick L. Splinter, Steven P. O’Hara, Olivia Morgenthaler, Lucía Valenzuela-Pérez, Hyun Se Kim Lee, Diana Jurk, Nicholas F. LaRusso, Petra Hirsova, João F. Passos   +22 more
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SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights

Cells
Cellular senescence regulates aging, tissue maintenance, and disease progression through the Senescence-Associated Secretory Phenotype (SASP), a secretory profile of cytokines, chemokines, growth factors, and matrix-remodeling enzymes.
Saud Alqahtani, Taha Alqahtani, Krishnaraju Venkatesan, Durgaramani Sivadasan, Rehab Ahmed, Nizar Sirag, Hassabelrasoul Elfadil, Hanem Abdullah Mohamed, Haseena T.A., Rasha Elsayed Ahmed, Pooja Muralidharan, Premalatha Paulsamy   +11 more
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Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Pharmaceuticals
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial reduction.
Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix   +2 more
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Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature [PDF]

European Journal of Medical Research
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Shangkun Zhao, Zhi Qiao, Roman Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu   +8 more
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NOTCH and the 2 SASPs of senescence [PDF]

Cell Cycle, 2016
The previous view that cellular senescence represented a stress-responsive tumor suppressor mechanism has been significantly revised recently with recognition of the profound non-autonomous functio...
Hoare, Matthew, Narita, Masashi
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