Results 11 to 20 of about 26,150 (274)

The Controversial Role of Senescence-Associated Secretory Phenotype (SASP) in Cancer Therapy

Molecular Cancer
Cellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP).
Qiang Tong, Kaixiu Li
exaly   +3 more sources

SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights

Cells
Cellular senescence regulates aging, tissue maintenance, and disease progression through the Senescence-Associated Secretory Phenotype (SASP), a secretory profile of cytokines, chemokines, growth factors, and matrix-remodeling enzymes.
Hassabelrasoul Abdelgadir, Rehab Ahmed, Premalatha Paulsamy   +2 more
exaly   +4 more sources

The double-edged sword of SASP in breast cancer: from tumor suppression to progression and therapy resistance [PDF]

Frontiers in Oncology
The senescence-associated secretory phenotype (SASP) represents a complex and dynamic collection of bioactive factors secreted by senescent cells, which exerts dual regulatory effects on breast cancer (BC) progression. When SASP is transiently expressed,
Xianneng Gao, Yunlong Zhang, Yue Sun, Tiefeng Xu   +3 more
doaj   +3 more sources

Senescence and the SASP: many therapeutic avenues [PDF]

Genes & Development, 2020
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, Jesus
core   +5 more sources

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP [PDF]

Frontiers in Molecular Biosciences, 2021
cellular senescence is a pathophysiological phenomenon in which proliferative cells enter cell cycle arrest following DNA damage and other stress signals.
Francis, Heather, Fuentes, Yessenia, Wu, Chaodong, Baiocchi, Leonardo, Kundu, Debjyoti, Kennedy, Lindsey, Alpini, Gianfranco, Sato, Keisaku, Meadows, Vik, Chakraborty, Sanjukta, Glaser, Shannon, Keisaku Sato, Yessenia Fuentes, Chaodong Wu, Sanjukta Chakraborty, Gianfranco Alpini, Debjyoti Kundu, Vik Meadows, Leonardo Baiocchi, Heather Francis, Shannon Glaser, Lindsey Kennedy   +21 more
core   +6 more sources

Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]

PLoS ONE, 2012
Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
doaj   +2 more sources

Machine learning–derived intracellular protein–based prognostic model reflecting a senescence-associated secretory phenotype-driven immunosuppressive microenvironment in lung adenocarcinoma [PDF]

PeerJ
Background This study aimed to investigate the associations of senescence-associated secretory phenotype (SASP)-related genes with the tumor immune microenvironment (TIME) and clinical outcomes in lung adenocarcinoma (LUAD) and to develop and evaluate a ...
Xiaoning Chang, Lihong Jiang, Lingxiao Zhang, Tong Ren, Chaoxin Fan, Pei Li   +5 more
doaj   +3 more sources

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

Oncotarget, 2016
Endothelial cell senescence is characterized by acquisition of senescence-associated secretory phenotype (SASP), able to promote inflammaging and cancer progression.
Rippo, Maria Rita, Tiano, Luca, Procopio, Antonio Domenico, Olivieri, Fabiola, Micucci, Carla, Giuliodori, Katia, BONAFE', MASSIMILIANO, Giuliani, Angelica, Offidani, Annamaria, Prattichizzo, Francesco, BRUGE', Francesca, Campanati, Anna, Brugè, Francesca, Marcheselli, Fiorella, Ceriello, Antonio, Bonafè, Massimiliano, Recchioni, Rina, DE CAROLIS, SABRINA   +17 more
core   +5 more sources

A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy [PDF]

Cancer Reports
Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP).
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak   +3 more
doaj   +2 more sources

Mitochondrial metabolism and epigenetic crosstalk drive SASP

Nature
Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP) 1 .
Rebecca A. Porritt, Francisco D. M. Marques, Anthony B. Lagnado, Ya Li, Amelia Mazzone, Yeaeun Han, Tianna M. Espe, Ana Catarina Franco, Jennifer L. Rowsey, Aaron Havas, Gung Lee, Stella Victorelli, Xue Lei, Jair Machado Espindola-Netto, Alexandre Gaspar-Maia, Oliver D. K. Maddocks, Alexander M. Washington, Taro Hitosugi, Jodie Birch, Rabi Murad, Diana Jurk, Peter D. Adams, Hélène Martini, Wazim Mohammed Ismail, Enis Kostallari, João F. Passos, Nicholas Pirius, Dominik Saul, Sundeep Khosla   +28 more
core   +3 more sources