Results 21 to 30 of about 6,153 (216)
Biomolecules, 2023 Background: Low back pain is a global health problem directly related to intervertebral disc (IVD) degeneration. Senolytic drugs (RG-7112 and o-Vanillin) target and remove senescent cells from IVDs in vitro, improving tissue homeostasis.
Matthew Mannarino +8 more
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Antioxidants, 2021 The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on
Cristina Mas-Bargues +4 more
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The Cancer SENESCopedia: A delineation of cancer cell senescence
Cell Reports, 2021 Summary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells.
Fleur Jochems +13 more
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EBioMedicine, 2019 Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson +32 more
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Biomedicines, 2023 Despite significant advances in the treatment of triple-negative breast cancer, this disease continues to pose a clinical challenge, with many patients ultimately suffering from relapse.
Abrar Softah +13 more
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Targeting senescence as an anticancer therapy
Molecular Oncology, 2022 Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate during
Laura Bousset, Jesús Gil
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Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
openaire +1 more source
Biomolecules, 2023 Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest.
Prashanta Silwal +6 more
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Discovery of new senolytics using machine learning
, 2022 Cellular senescence is a stress response characterised by a permanent cell cycle arrest and a proinflammatory secretome. In addition to its tumour suppressor role, senescence is involved in ageing and promotes many disease processes such as cancer, type ...
Carragher, Neil O. +16 more
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Evaluating the neuroprotective impact of senolytic drugs on human vision
Scientific Reports, 2020 Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression.
Nevin W. El-Nimri +6 more
doaj +1 more source