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Code and data for "Discovery of senolytics using machine learning"
, 2023 <p>Code and data for paper "Discovery of senolytics using machine learning" by Smer-Barreto et al, 2023. Files contain the datasets employed for model training and computational screening, as well as a jupyter notebook with
Smer-Barreto, Vanessa +12 more
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Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies
Biology, 2023 Cellular senescence is a state of irreversible growth arrest with profound phenotypic changes, including the senescence-associated secretory phenotype (SASP).
Amit K. Dey +7 more
doaj +1 more source
Cardiac Glycosides as Senolytic Compounds [PDF]
Trends in Molecular Medicine, 2020 The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts.
Martin, Nadine +2 more
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Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges
Journal of Cardiovascular Development and Disease, 2023 Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is hallmarked by a progressive decrease in cell growth, differentiation, and biological activities.
Dan Li +5 more
doaj +1 more source
Strategies for senolytic drug discovery
Aging Cell, 2023 AbstractSenolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. Since the discovery of the first senolytics in 2015, the number of known senolytic agents has grown dramatically.
Helen Power +3 more
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A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo [PDF]
, 2023 Senescence drives the onset and severity of multiple ageing-associated diseases and frailty. As a result, there has been an increased interest in mechanistic studies and in the search for compounds targeting senescent cells, known as senolytics ...
Morsli, S. +7 more
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Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
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The Clinical Potential of Senolytic Drugs [PDF]
Journal of the American Geriatrics Society, 2017 Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic ...
James L, Kirkland +4 more
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Discovery of new senolytics using machine learning
, 2022 Cellular senescence is a stress response characterised by a permanent cell cycle arrest and a proinflammatory secretome. In addition to its tumour suppressor role, senescence is involved in ageing and promotes many disease processes such as cancer, type ...
Carragher, Neil O. +7 more
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Senolytics for Cancer Therapy: Is All that Glitters Really Gold?
, 2021 Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies.
Valerie J. Carpenter +2 more
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