Results 21 to 30 of about 6,461 (225)

Deletion of SA β-Gal+ Cells Using Senolytics Improves Muscle Regeneration in Old Mice [PDF]

, 2021
Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole-body metabolism, but their role in tissue reparative processes is incompletely understood.
Brightwell, Camille R., Dungan, Cory M., Englund, Davis A., Filareto, Antonio, Franti, Michael, Fry, Christopher S., Hettinger, Zachary, Liu, Zheng, Murach, Kevin A., Peterson, Charlotte A., Tang, Zuo Jian, VonLehmden, Georgia L., Zdunek, Christopher J.   +12 more
core   +2 more sources

Strategies for senolytic drug discovery

Aging Cell, 2023
AbstractSenolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. Since the discovery of the first senolytics in 2015, the number of known senolytic agents has grown dramatically.
Helen Power, Peter Valtchev, Fariba Dehghani, Aaron Schindeler   +3 more
openaire   +2 more sources

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Nature Communications, 2020
Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity.
Yonghan He, Xuan Zhang, Jianhui Chang, Ha-Neui Kim, Peiyi Zhang, Yingying Wang, Sajid Khan, Xingui Liu, Xin Zhang, Dongwen Lv, Lin Song, Wen Li, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Yuma T. Ortiz, Vivekananda Budamagunta, Jennifer H. Elisseeff, Judith Campisi, Maria Almeida, Guangrong Zheng, Daohong Zhou   +21 more
doaj   +1 more source

Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products

Biomolecules, 2021
Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested in experimental models that the elimination of senescent cells with pharmacological ...
Oscar Salvador Barrera-Vázquez, Juan Carlos Gómez-Verjan, Gil Alfonso Magos-Guerrero   +2 more
doaj   +1 more source

Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies

Biology, 2023
Cellular senescence is a state of irreversible growth arrest with profound phenotypic changes, including the senescence-associated secretory phenotype (SASP).
Amit K. Dey, Reema Banarjee, Mozhgan Boroumand, Delaney V. Rutherford, Quinn Strassheim, Thedoe Nyunt, Bradley Olinger, Nathan Basisty   +7 more
doaj   +1 more source

Unleashing endogenous regeneration by senolytics. [PDF]

J Transl Med
Boddu NK, Kesari S, Chavez BA, Bajnath A, Wheatley MD, Zhang Q, Wang Y, Ellis J, Lin E, Genovese J, Robles MFN.   +10 more
europepmc   +2 more sources

Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges

Journal of Cardiovascular Development and Disease, 2023
Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is hallmarked by a progressive decrease in cell growth, differentiation, and biological activities.
Dan Li, Yongnan Li, Hong Ding, Yuqin Wang, Yafei Xie, Xiaowei Zhang   +5 more
doaj   +1 more source

Galactose‐modified duocarmycin prodrugs as senolytics [PDF]

Aging Cell, 2019
Abstract Senescence is a stable growth arrest that impairs the replication of damaged, old or preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells accumulate during ageing and are associated with cancer, fibrosis and many age‐related pathologies.
Guerrero, Ana, Guiho, Romain, Herranz, Nicolás, Uren, Anthony, Withers, Dominic J., Martínez-Barbera, Juan Pedro, Tietze, Lutz F., Gil, Jesús   +7 more
openaire   +7 more sources

A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]

, 2020
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan, Campisi, Judith, Ferrucci, Luigi, Holtz, Anja, Jeon, Ok Hee, Kale, Abhijit, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Schilling, Birgit, Shah, Samah, Sharma, Vagisha   +11 more
core   +1 more source

Black Ginseng Ameliorates Cellular Senescence via p53-p21/p16 Pathway in Aged Mice

Biology, 2022
Cellular senescence, one of the hallmarks of aging, refers to permanent cell cycle arrest and is accelerated during the aging process. Black ginseng (BG), prepared by a repeated steaming and drying process nine times from fresh ginseng (Panax ginseng C.A.
Su-Jeong Lee, Da-Yeon Lee, Jennifer F. O’Connell, Josephine M. Egan, Yoo Kim   +4 more
doaj   +1 more source