Results 31 to 40 of about 5,180 (222)

Black Ginseng Ameliorates Cellular Senescence via p53-p21/p16 Pathway in Aged Mice

Biology, 2022
Cellular senescence, one of the hallmarks of aging, refers to permanent cell cycle arrest and is accelerated during the aging process. Black ginseng (BG), prepared by a repeated steaming and drying process nine times from fresh ginseng (Panax ginseng C.A.
Su-Jeong Lee, Da-Yeon Lee, Jennifer F. O’Connell, Josephine M. Egan, Yoo Kim   +4 more
doaj   +1 more source

Primary Graft Dysfunction: The Role of Aging in Lung Ischemia-Reperfusion Injury

Frontiers in Immunology, 2022
Transplant centers around the world have been using extended criteria donors to remedy the ongoing demand for lung transplantation. With a rapidly aging population, older donors are increasingly considered.
Maximilian J. Roesel, Maximilian J. Roesel, Nirmal S. Sharma, Nirmal S. Sharma, Andreas Schroeter, Andreas Schroeter, Tomohisa Matsunaga, Tomohisa Matsunaga, Yao Xiao, Hao Zhou, Stefan G. Tullius   +10 more
doaj   +1 more source

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney diseaseResearch in context

EBioMedicine, 2019
Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, Yi Zhu, Tamara Tchkonia, James L. Kirkland   +32 more
doaj   +1 more source

Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study

Frontiers in Pharmacology, 2023
Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong, Li Ping Wong, Haridah Alias, Kit Mun Tan, Pooi Fong Wong, Dharmani Devi Murugan, Zhijian Hu, Yulan Lin   +7 more
doaj   +1 more source

Evaluating the neuroprotective impact of senolytic drugs on human vision

Scientific Reports, 2020
Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression.
Nevin W. El-Nimri, Spencer M. Moore, Linda M. Zangwill, James A. Proudfoot, Robert N. Weinreb, Dorota Skowronska-Krawczyk, Sally L. Baxter   +6 more
doaj   +1 more source

Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

Cells, 2023
Landmark genetic studies have revealed the effect of complement biology and its regulation on the pathogenesis of age-related macular degeneration (AMD).
Adnan H. Khan, Itay Chowers, Andrew J. Lotery   +2 more
doaj   +1 more source

Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan [PDF]

Innovation in Aging, 2020
Abstract Cellular senescence is a cell fate decision that is made by many mammalian cell types in response to damage, stress or certain physiological signals. Senescent cells arrest proliferation, essentially permanently, and develop a complex multi-component senescence-associated secretory phenotype (SASP).
openaire   +1 more source

Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

, 2023
Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, which are overexpressed in senescent cells, limiting specificity and ...
Park, Gaeun, Hong, Seongho, Jana, Batakrishna, Lee, Hyungwoo, Kim, Dohyun, Chae, Jae-Byoung, Sim, Youjung, Lee, Jaeeun, Ryu, Ja-Hyoung, Kim, Sangpil, Chung, Hyewon, Park, Chul-Woo, Kim, Chaekyu   +12 more
core   +2 more sources

A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics [PDF]

, 2022
Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors that are involved in diverse signaling pathways, influencing kidney fibrosis.
Masereeuw, Rosalinde, Nguyen, Tri Q, Mihajlovic, Milos, Goldschmeding, Roel, Yang, Yi, Valentijn, Floris   +5 more
core   +2 more sources

From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs

Open Biology, 2022
Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression.
Valentin L'Hôte, Carl Mann, Jean-Yves Thuret   +2 more
doaj   +1 more source