Results 11 to 20 of about 6,153 (216)

A pipeline for senolytics

The Journal of Clinical Investigation
There is intense interest in identifying compounds that selectively kill senescent cells, termed senolytics, for ameliorating age-related comorbidities.
Sundeep Khosla
doaj   +4 more sources

Senolytics and senostatics as adjuvant tumour therapy [PDF]

EBioMedicine, 2019
Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline. In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it blocks tumour growth. However, this is frequently incomplete, and
Susan Short, Edward Fielder, Satomi Miwa, Thomas von Zglinicki   +3 more
doaj   +5 more sources

MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice

Scientific Reports
Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effectiveness of senolytic drugs in reducing liver damage in mice with MASLD is not clear. Additionally, MASLD has been
Jessica D. Hense, Driele N. Garcia, Bianka M. Zanini, Mariana M. Barreto, Giulia C. Perreira, José V. V. Isola, Camila de Brito, Michal Fornalik, Samim A. Mondal, Bianca M. Ávila, Thais L. Oliveira, Heather C. Rice, Charles I. Lacy, Rodrigo A. Vaucher, Jeffrey B. Mason, Michal M. Masternak, Michael B. Stout, Augusto Schneider   +17 more
doaj   +2 more sources

The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches

Biomolecules
The biological process of aging is influenced by a complex interplay of genetic, environmental, and epigenetic factors. Recent advancements in the fields of epigenetics and senolytics offer promising avenues for understanding and addressing age-related ...
Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner   +5 more
doaj   +2 more sources

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +2 more sources

Unleashing endogenous regeneration by senolytics

Journal of Translational Medicine
Abstract Regenerative medicine holds significant promise for the treatment of chronic diseases by harnessing the body’s innate capacity to repair and restore physiological function. However, regenerative activity declines markedly with age, a phenomenon traditionally attributed to depletion/exhaustion of progenitor cell pools.
Boddu, Navneet K., Kesari, Santosh, Chavez, Brandy A., Bajnath, Anil, Wheatley, Maxim D., Zhang, Qianyi, Wang, Yiqiao, Ellis, Joseph, Lin, Emma, Genovese, Jorge, Robles, Maria Fatima N.   +10 more
openaire   +3 more sources

Code and data for "Discovery of senolytics using machine learning"

, 2023
<p>Code and data for paper "Discovery of senolytics using machine learning" by Smer-Barreto et al, 2023. Files contain the datasets employed for model training and computational screening, as well as a jupyter notebook with
Smer-Barreto, Vanessa, Quintanilla, Andrea, Elliott, Richard J. R., Lorente-Macías, Álvaro, Carragher, Neil O., Acosta, Juan Carlos, Unciti-Broceta, Asier, Oyarzún, Diego A., Elliot, Richard J. R., Sun, Jiugeng, Dawson, John C., Campa, Víctor M., Acosta, Juan C., School of Population Health Sciences, Institute of Genetics and Cancer, Centre for Engineering Biology, School of Genetics and Cancer, Institute for Adaptive and Neural Computation, Edinburgh Cancer Research Centre, School of Informatics, Data Science and Artificial Intelligence   +20 more
core   +2 more sources

Cardiac Glycosides as Senolytic Compounds [PDF]

Trends in Molecular Medicine, 2020
The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts.
Martin, Nadine, Soriani, Olivier, Bernard, David   +2 more
openaire   +2 more sources

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

, 2021
Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies.
Valerie J. Carpenter, Tareq Saleh, David A. Gewirtz   +2 more
core   +1 more source

Cellular Senescence and Ageing: Mechanisms and Interventions

Frontiers in Aging, 2022
The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident.
Andreas Mylonas, Ana O’Loghlen
doaj   +1 more source