Results 11 to 20 of about 5,180 (222)

The Role of Senolytics in Osteoporosis

Biomolecules
Cellular senescence is a fundamental contributor to numerous dysfunctions and degenerative diseases, including osteoporosis. In genetically modified and preclinical animal models, therapeutic strategies targeting persistent senescent cells have been ...
Erman Chen, Jingjing Zhang, Han Chen, Weixu Li   +3 more
doaj   +5 more sources

A pipeline for senolytics

The Journal of Clinical Investigation
There is intense interest in identifying compounds that selectively kill senescent cells, termed senolytics, for ameliorating age-related comorbidities.
Sundeep Khosla
doaj   +4 more sources

Unleashing endogenous regeneration by senolytics. [PDF]

J Transl Med
Regenerative medicine holds significant promise for the treatment of chronic diseases by harnessing the body’s innate capacity to repair and restore physiological function.
Boddu NK, Kesari S, Chavez BA, Bajnath A, Wheatley MD, Zhang Q, Wang Y, Ellis J, Lin E, Genovese J, Robles MFN.   +10 more
europepmc   +4 more sources

Senolytics and senostatics as adjuvant tumour therapy [PDF]

EBioMedicine, 2019
Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline. In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it blocks tumour growth. However, this is frequently incomplete, and
Susan Short, Edward Fielder, Satomi Miwa, Thomas von Zglinicki   +3 more
doaj   +2 more sources

MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice

Scientific Reports
Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effectiveness of senolytic drugs in reducing liver damage in mice with MASLD is not clear. Additionally, MASLD has been
Jessica D. Hense, Driele N. Garcia, Bianka M. Zanini, Mariana M. Barreto, Giulia C. Perreira, José V. V. Isola, Camila de Brito, Michal Fornalik, Samim A. Mondal, Bianca M. Ávila, Thais L. Oliveira, Heather C. Rice, Charles I. Lacy, Rodrigo A. Vaucher, Jeffrey B. Mason, Michal M. Masternak, Michael B. Stout, Augusto Schneider   +17 more
doaj   +2 more sources

Galactose‐modified duocarmycin prodrugs as senolytics [PDF]

Aging Cell, 2019
Abstract Senescence is a stable growth arrest that impairs the replication of damaged, old or preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells accumulate during ageing and are associated with cancer, fibrosis and many age‐related pathologies.
Guerrero, Ana, Guiho, Romain, Herranz, Nicolás, Uren, Anthony, Withers, Dominic J., Martínez-Barbera, Juan Pedro, Tietze, Lutz F., Gil, Jesús   +7 more
openaire   +8 more sources

The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches

Biomolecules
The biological process of aging is influenced by a complex interplay of genetic, environmental, and epigenetic factors. Recent advancements in the fields of epigenetics and senolytics offer promising avenues for understanding and addressing age-related ...
Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner   +5 more
doaj   +2 more sources

Cardiac glycosides are broad-spectrum senolytics [PDF]

Nature Metabolism, 2019
Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells.
Ana Guerrero, Nicolás Herranz, Bin Sun, Verena Wagner, Suchira Gallage, Romain Guiho, Katharina Wolter, Joaquim Pombo, Elaine E. Irvine, Andrew J. Innes, Jodie Birch, Justyna Glegola, Saba Manshaei, Danijela Heide, Gopuraja Dharmalingam, Jule Harbig, Antoni Olona, Jacques Behmoaras, Daniel Dauch, Anthony G. Uren, Lars Zender, Santiago Vernia, Juan Pedro Martínez-Barbera, Mathias Heikenwalder, Dominic J. Withers, Jesús Gil   +25 more
core   +8 more sources

Sex, senescence, senolytics, and cognition [PDF]

Frontiers in Aging Neuroscience
This review focuses on sexual dimorphism in cellular senescence and senolytic treatment in relation to brain health and age-related cognitive decline. The stressors of aging, DNA damage, inflammation, and oxidative stress induce cell senescence, a hallmark of aging.
Thomas C. Foster, Thomas C. Foster, Ashok Kumar   +2 more
openaire   +4 more sources

Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions

Biomolecules
Cellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). While transient senescence
Timur Saliev, Prim B. Singh
doaj   +2 more sources