Results 41 to 50 of about 6,461 (225)
Photoactivatable senolysis with single-cell resolution delays aging [PDF]
, 2023 Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have been shown to promote healthy lifespan. However, it is challenging to achieve precise, broad-spectrum and tractable senolysis.
Gao, Ying +8 more
core +3 more sources
DNA damage: A main determinant of vascular aging [PDF]
, 2016 Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of ...
Bautista-Niño, P.K. (Paula) +4 more
core +2 more sources
Senescence and the SASP: many therapeutic avenues [PDF]
, 2020 Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, J
core +1 more source
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
Open Biology, 2022 Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression.
Valentin L'Hôte +2 more
doaj +1 more source
From genoprotection to rejuvenation
Frontiers in Bioscience-Landmark, 2020 Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
doaj +1 more source
Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice [PDF]
, 2023 The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro ...
Bertos, Antonio R. +15 more
core +2 more sources
Pharmacology Research & Perspectives, 2023 Previous investigations have demonstrated that treatment of animals with rapamycin increases levels of autophagy, which is a process by which cells degrade intracellular detritus, thus suppressing the emergence of senescent cells, whose pro‐inflammatory ...
Kitti Szőke +8 more
doaj +1 more source
Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing? [PDF]
, 2021 It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing.
Balistreri, Carmela Rita +2 more
core +1 more source
Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
openaire +1 more source
Senolytic therapies for healthy longevity [PDF]
Science, 2019 Clearing senescent cells with targeted drugs could combat age-associated ...
openaire +2 more sources