Results 41 to 50 of about 5,180 (222)

From genoprotection to rejuvenation

Frontiers in Bioscience-Landmark, 2020
Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
doaj   +1 more source

Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice

Pharmacology Research & Perspectives, 2023
Previous investigations have demonstrated that treatment of animals with rapamycin increases levels of autophagy, which is a process by which cells degrade intracellular detritus, thus suppressing the emergence of senescent cells, whose pro‐inflammatory ...
Kitti Szőke, Beáta Bódi, Zoltán Hendrik, Attila Czompa, Alexandra Gyöngyösi, Donald David Haines, Zoltán Papp, Árpád Tósaki, István Lekli   +8 more
doaj   +1 more source

NAD ⁺ , Senolytics, or Pyruvate for Healthy Aging? [PDF]

Nutrition and Metabolic Insights, 2021
In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD + ) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD +
openaire   +3 more sources

Is exercise a senolytic medicine? A systematic review [PDF]

Aging Cell, 2020
AbstractCellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years ...
Xiang‐Ke Chen, Zhen‐Ni Yi, Gordon Tin‐Chun Wong, Kazi Md. Mahmudul Hasan, Joseph Shiu‐Kwong Kwan, Alvin Chun‐Hang Ma, Raymond Chuen‐Chung Chang   +6 more
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New therapies targeting aging cells in the skin

Journal of Medical Science, 2023
Senescence is accompanied by numerous processes that lead to alterations in cell metabolism, cell cycle arrest, and, increased production and secretion of senescence-associated secretory phenotype (SASP).
Anna Paszel-Jaworska, Justyna Gornowicz-Porowska, Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Violetta Krajka-Kuźniak, Maciej Stawny, Aleksandra Gostyńska, Michał Masternak, Błażej Rubiś   +8 more
doaj   +1 more source

Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs. [PDF]

Molecules
The accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the limited number of known senolytics and the incomplete understanding of their mechanisms. This study
Li J, Zhao K, Yang G, Lv H, Zhang R, Li S, Chen Z, Xu M, Yang N, Dai S.   +9 more
europepmc   +4 more sources

Therapeutic Potential of Senolytics in Cardiovascular Disease [PDF]

Cardiovascular Drugs and Therapy, 2020
AbstractAgeing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is associated with both an increased prevalence of cardiovascular disease including heart failure, coronary artery disease, and myocardial infarction.
Emily Dookun, João F. Passos, Helen M. Arthur, Gavin D. Richardson   +3 more
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Cellular Senescence and Ageing: Mechanisms and Interventions

Frontiers in Aging, 2022
The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident.
Andreas Mylonas, Ana O’Loghlen
doaj   +1 more source

Identification of gingerenone A as a novel senolytic compound

PLOS ONE, 2022
Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age phenotypes in mouse models and there is some initial evidence that it may improve the health of persons with chronic diseases. In this study, we employed
Ruin Moaddel, Martina Rossi, Stephanie Rodriguez, Rachel Munk, Mohammed Khadeer, Kotb Abdelmohsen, Myriam Gorospe, Luigi Ferrucci   +7 more
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Senolytic drugs: from discovery to translation [PDF]

Journal of Internal Medicine, 2020
AbstractSenolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, mortality ...
J. L. Kirkland, T. Tchkonia
openaire   +2 more sources