Results 61 to 70 of about 6,153 (216)

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

Senolytics and their clinical potential

, 2018
Senolytics bieten die Möglichkeit einer neuen Behandlungsmethode für altersbedingte Erkrankungen, viele mit schlechten Prognosen und eingeschränkten Therapiemöglichkeiten wie Osteoporose, Lebersteatose oder Lungenfibrose.
Riemer, Natalie Mathab
core   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs

Molecules
The accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the limited number of known senolytics and the incomplete understanding of their mechanisms. This study
Jinjun Li, Kai Zhao, Guotai Yang, Haohao Lv, Renxin Zhang, Shuhan Li, Zhiyuan Chen, Min Xu, Naixue Yang, Shaoxing Dai   +9 more
openaire   +3 more sources

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Metabolites
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
doaj   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls [PDF]

Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the cause of death in 40% of individuals over 65 years old.
Spyridopoulos I, Owens WA, Richardson GD, Dookun E, Walaszczyk A   +4 more
core   +3 more sources

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

European Journal of Medical Research
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Shangkun Zhao, Zhi Qiao, Roman Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu   +8 more
doaj   +1 more source

Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells?

Frontiers in Cell and Developmental Biology
Aging is characterized by gradual deterioration of organ or tissue function and its ability to maintain homeostasis of the different physiological processes.
Barbora Judita Kasperova, Barbora Judita Kasperova, Anna Cinkajzlova, Ludek Horvath, Petr Svoboda, Petr Svoboda, Martin Haluzik, Martin Haluzik, Sona Stemberkova Hubackova, Sona Stemberkova Hubackova   +9 more
doaj   +1 more source