Results 51 to 60 of about 6,461 (225)
Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension. [PDF]
, 2020 Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset ...
Jabari, Mary +7 more
core
NAD+, Senolytics, or Pyruvate for Healthy Aging? [PDF]
Nutrition and Metabolic Insights, 2021 In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD+) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD+ precursors was first demonstrated with its new role in DNA damage repairing in mice ...
openaire +3 more sources
Therapeutic Potential of Senolytics in Cardiovascular Disease [PDF]
Cardiovascular Drugs and Therapy, 2020 AbstractAgeing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is associated with both an increased prevalence of cardiovascular disease including heart failure, coronary artery disease, and myocardial infarction.
Emily Dookun +3 more
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Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
doaj +1 more source
Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease
, 2017 Cellular senescence, the irreversible loss of replicative capacity in somatic cells, plays a causal role in the development of age-related pathology and in a number of age-related chronic inflammatory diseases.
Barnes, PJ, Birch, J, Passos, JF
core +1 more source
344 The Potential Benefits of Using Senolytics in Colorectal Cancer Treatment
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Anti-cancer therapies, such as chemotherapy, can induce senescence. Senescent cells may produce factors that can promote tumor progression.
Valerie Gallegos +6 more
doaj +1 more source
The Clinical Potential of Senolytic Drugs [PDF]
Journal of the American Geriatrics Society, 2017 Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic ...
James L, Kirkland +4 more
openaire +2 more sources
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar +10 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source