Results 51 to 60 of about 463 (110)

Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs

Molecules
The accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the limited number of known senolytics and the incomplete understanding of their mechanisms. This study
Jinjun Li, Kai Zhao, Guotai Yang, Haohao Lv, Renxin Zhang, Shuhan Li, Zhiyuan Chen, Min Xu, Naixue Yang, Shaoxing Dai   +9 more
openaire   +3 more sources

The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches

Biomolecules
The biological process of aging is influenced by a complex interplay of genetic, environmental, and epigenetic factors. Recent advancements in the fields of epigenetics and senolytics offer promising avenues for understanding and addressing age-related ...
Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner   +5 more
doaj   +1 more source

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

European Journal of Medical Research
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Shangkun Zhao, Zhi Qiao, Roman Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu   +8 more
doaj   +1 more source

From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Cells
Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial ...
Timur Saliev, Prim B. Singh
doaj   +1 more source

Sex, senescence, senolytics, and cognition

Frontiers in Aging Neuroscience
This review focuses on sexual dimorphism in cellular senescence and senolytic treatment in relation to brain health and age-related cognitive decline. The stressors of aging, DNA damage, inflammation, and oxidative stress induce cell senescence, a hallmark of aging.
Thomas C. Foster, Thomas C. Foster, Ashok Kumar   +2 more
openaire   +3 more sources

Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐Senolytics

Advanced Healthcare Materials
AbstractCellular senescence is a significant risk factor for aging and age‐related diseases (ARD). The canonical senolytics Dasatinib and Quercetin (DQ) have shown promise in clearing senescent cells (SnCs); however, the lack of selectivity poses a challenge in achieving optimal outcomes.
Hairui Zhang, Xiaoling Xu, Xin Shou, Wucan Liao, Chengkang Jin, Changjiang Chen, Chen Zhang, Wenhua Gao, Junfeng Zhang, Weihong Ge, Liyun Shi   +10 more
openaire   +2 more sources

Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy

Pharmaceuticals
Background/Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the elderly. Cellular
Antonio Battaglia-Vieni, Vanessa Marchant, Lucia Tejedor-Santamaria, Cristina García-Caballero, Elena Flores-Salguero, María Piedad Ruiz-Torres, Sandra Rayego-Mateos, Ana Belen Sanz, Alberto Ortiz, Marta Ruiz-Ortega   +9 more
doaj   +1 more source

Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions

Biomolecules
Cellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). While transient senescence
Timur Saliev, Prim B. Singh
doaj   +1 more source

Senolytic effects of a modified Gingerenone A

npj Aging
Abstract Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases.
Moaddel, Ruin, Sanehira, Chad, Keyes, Gregory, Cui, Chang-Yi, Ahmadkhaniha, Reza, Candia, Julián, Price, Nathan L., Eckroth, Sarah, Middleton, Bryce, Khadeer, Mohammed, Mazucanti, Caio H., McDevitt, Ross A., Gorospe, Myriam, de Cabo, Rafael, Egan, Josephine M., Ramsden, Christopher E., Ferrucci, Luigi   +16 more
openaire   +2 more sources

MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells

Vascular Biology, 2019
During organism aging, the process of cellular senescence is triggered by critical stressors such as DNA damage, oncogenes, oxidative stress, and telomere erosion, and vascular cells are not exempted.
Ornella Colpani, Gaia Spinetti
doaj   +1 more source