Results 31 to 40 of about 16,580 (182)

Deletion of cyclin dependent kinase inhibitor 2a gene as a marker of oropharyngeal carcinomas non-associated with human papillomavirus and its prognostic value

Medičnì Perspektivi
Patients with human papilloma virus associated oropharyngeal squamous cell carcinoma generally have better treatment outcomes and prognosis compared to those with non-papillomavirus-associated oropharyngeal squamous cell carcinoma.
I.S. Shponka, O.O. Bondarenko, O.V. Kovtunenko, V.V. Rakhmanov   +3 more
doaj   +1 more source

The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. [PDF]

PLoS Biology, 2013
The INhibitor of Growth (ING) proteins act as type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. Expression of the alternatively spliced ING1a tumor suppressor
Uma Karthika Rajarajacholan, Subhash Thalappilly, Karl Riabowol   +2 more
doaj   +1 more source

Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease

Frontiers in Medicine
ContextShenyuan Granules (SYG), a traditional Chinese medicine preparation, are clinically used for treating chronic kidney diseases. However, the role of Klotho in modulating cellular senescence via the p16/p21 pathway and its involvement in the ...
Xinyuan Guo, Siyang Zhang, Qingqing Sun, Huimeng Li, Lan Wang, Lan Wang, Lan Wang, Lan Wang   +7 more
doaj   +1 more source

p16/Cyclin-Dependent Kinase Inhibitor 2A Deficiency in Human Melanocyte Senescence, Apoptosis, and Immortalization: Possible Implications for Melanoma Progression [PDF]

JNCI Journal of the National Cancer Institute, 2003
The melanoma susceptibility locus cyclin-dependent kinase inhibitor 2A encodes two unrelated cell growth inhibitors, p16 and alternative reading frame (ARF). In fibroblasts, both proteins are implicated in cellular senescence, a key barrier to tumor development. The p16 coding sequence is more often mutated in melanoma families than is the ARF sequence.
Sviderskaya, E V, Gray-Schopfer, V C, Hill, S P, Smit, N P, Evans-Whipp, T J, Bond, J, Hill, L, Bataille, V, Peters, G, Kipling, D, Wynford-Thomas, D, Bennett, D C   +11 more
openaire   +2 more sources

TUMOR SUPPRESSING FUNCTIONS OF p16INK4a - A REVIEW

Journal of Dentistry Indonesia, 2015
DNA damage can have particularly severe carcinogenic influence if it incapacitates the cellular machinery normally protecting the cell from the effects of genomic damage. The protective functions involve not only DNA repair and apoptosis (programmed cell
Elza Ibrahim Auerkari, Ismu Suharsono Suwelo, Achmad Tjarta, T. W. Rahardjo, Kazuhiro Eto, Masa-Aki Ikeda   +5 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Evaluation of prognostic histological parameters proposed for pleural mesothelioma in diffuse malignant peritoneal mesothelioma. A short report

Diagnostic Pathology, 2021
Introduction Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with poor survival that shares some similarities with the best-known pleural variant, pleural mesothelioma.
Federica Pezzuto, Luigi Vimercati, Francesco Fortarezza, Andrea Marzullo, Antonio Pennella, Domenica Cavone, Alessandra Punzi, Concetta Caporusso, Antonio d’Amati, Teresa Lettini, Gabriella Serio   +10 more
doaj   +1 more source

Comprehensive Analysis Revealed that CDKN2A is a Biomarker for Immune Infiltrates in Multiple Cancers

Frontiers in Cell and Developmental Biology, 2021
The CDKN2A (cyclin dependent kinase inhibitor 2A/multiple tumor suppressor 1) gene, also known as the P16 gene, encodes multiple tumor suppressor 1 (MTS1), which belongs to the INK4 family.
Zheng Chen, Zheng Chen, Yingjie Guo, Yingjie Guo, Da Zhao, Da Zhao, Quan Zou, Fusheng Yu, Lijun Zhang, Lei Xu   +9 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

Cell & Bioscience, 2021
Background Autophagy is required for oogenesis and plays a critical role in response to aging caused by oxidative stress. However, there have been no reports on regulation of cytoprotective autophagy in female germline stem cells (FGSCs) in response to ...
Xiaoyan Yuan, Geng. G. Tian, Xiuying Pei, Xiaopeng Hu, Ji Wu   +4 more
doaj   +1 more source