Results 21 to 30 of about 16,725 (189)

The effect of resveratrol supplementation on the expression levels of factors associated with cellular senescence and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: study protocol for a double-blind controlled randomised clinical trial

BMJ Open, 2019
Introduction Over the past decades, the number of people with type 2 diabetes (T2D) has increased globally. One of the major complications in these patients is cardiovascular disease; it seems that the cell proliferation inhibition can improve vascular ...
Shima Abdollahi, Amin Salehi-Abargouei, Mahtab Tabatabaie, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Masoud Rahmanian, Omid Toupchian, Elham Karimi-Nazari, Hassan Mozaffari-Khosravi   +8 more
doaj   +1 more source

Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs. [PDF]

PLoS ONE, 2014
Epigenetic silencing of tumour suppressor genes has been observed in various cancers. Looking at hepatocellular carcinoma (HCC) specific protein silencing was previously demonstrated to be associated with the Hepatitis C virus (HCV).
Inga Hinrichsen, Matthias Kemp, Jan Peveling-Oberhag, Sandra Passmann, Guido Plotz, Stefan Zeuzem, Angela Brieger   +6 more
doaj   +1 more source

Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression

Biomolecules, 2020
Genetic alterations in the INK4a/ARF (or CDKN2A) locus have been reported in many cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast, and pancreatic cancers.
Zizhen Ming, Su Yin Lim, Helen Rizos
doaj   +1 more source

Histopathological characteristics and coexpression of p53 and p16INK4a proteins in renal cancer [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Renal carcinoma represents histologically heterogeneous group of malignant tumors, with various clinical aggressiveness. The frequency of p53 mutation in primal renal carcinoma is rare, although there are information about its ...
Živković Slađana, Kostov Miloš, Pavlović Svetlana, Mijović Žaklina   +3 more
doaj   +1 more source

The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouse [PDF]

Reproductive Biology and Endocrinology, 2003
Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs).In this study we tested the expression of CDKIs p15, p16, p21 and p27 by immunohistochemistry to determine the role of CDKIs in the initiation of primordial follicle growth.
Bayrak Aykut, Oktay Kutluk
openaire   +3 more sources

Deletion of cyclin dependent kinase inhibitor 2a gene as a marker of oropharyngeal carcinomas non-associated with human papillomavirus and its prognostic value

Medičnì Perspektivi
Patients with human papilloma virus associated oropharyngeal squamous cell carcinoma generally have better treatment outcomes and prognosis compared to those with non-papillomavirus-associated oropharyngeal squamous cell carcinoma.
I.S. Shponka, O.O. Bondarenko, O.V. Kovtunenko, V.V. Rakhmanov   +3 more
doaj   +1 more source

The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. [PDF]

PLoS Biology, 2013
The INhibitor of Growth (ING) proteins act as type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. Expression of the alternatively spliced ING1a tumor suppressor
Uma Karthika Rajarajacholan, Subhash Thalappilly, Karl Riabowol   +2 more
doaj   +1 more source

Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease

Frontiers in Medicine
ContextShenyuan Granules (SYG), a traditional Chinese medicine preparation, are clinically used for treating chronic kidney diseases. However, the role of Klotho in modulating cellular senescence via the p16/p21 pathway and its involvement in the ...
Xinyuan Guo, Siyang Zhang, Qingqing Sun, Huimeng Li, Lan Wang, Lan Wang, Lan Wang, Lan Wang   +7 more
doaj   +1 more source

p16/Cyclin-Dependent Kinase Inhibitor 2A Deficiency in Human Melanocyte Senescence, Apoptosis, and Immortalization: Possible Implications for Melanoma Progression [PDF]

JNCI Journal of the National Cancer Institute, 2003
The melanoma susceptibility locus cyclin-dependent kinase inhibitor 2A encodes two unrelated cell growth inhibitors, p16 and alternative reading frame (ARF). In fibroblasts, both proteins are implicated in cellular senescence, a key barrier to tumor development. The p16 coding sequence is more often mutated in melanoma families than is the ARF sequence.
Sviderskaya, E V, Gray-Schopfer, V C, Hill, S P, Smit, N P, Evans-Whipp, T J, Bond, J, Hill, L, Bataille, V, Peters, G, Kipling, D, Wynford-Thomas, D, Bennett, D C   +11 more
openaire   +2 more sources

TUMOR SUPPRESSING FUNCTIONS OF p16INK4a - A REVIEW

Journal of Dentistry Indonesia, 2015
DNA damage can have particularly severe carcinogenic influence if it incapacitates the cellular machinery normally protecting the cell from the effects of genomic damage. The protective functions involve not only DNA repair and apoptosis (programmed cell
Elza Ibrahim Auerkari, Ismu Suharsono Suwelo, Achmad Tjarta, T. W. Rahardjo, Kazuhiro Eto, Masa-Aki Ikeda   +5 more
doaj   +1 more source