Results 21 to 30 of about 16,580 (182)

Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies

Oncology Reports, 2006
The p16 protein is a cyclin-dependent kinase (CDK) inhibitor, which plays an important role in the regulation of the cell cycle by inactivating the cyclin-dependent kinase (CDK) that phosphorylates the retinoblastoma (Rb) protein. Overexpression of p16 protein has been found in many types of human malignancy.
Looi, Koksun, Megliorino, Roxanne, Shi, Fu-Dong, Peng, Xuan-Xian, Chen, Yao, Zhang, Jian-Ying   +5 more
openaire   +3 more sources

p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.

PLoS ONE, 2011
BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer.
Huda H Al-Khalaf, Dilek Colak, Maher Al-Saif, Albandary Al-Bakheet, Siti-Faujiah Hendrayani, Nujoud Al-Yousef, Namik Kaya, Khalid S Khabar, Abdelilah Aboussekhra   +8 more
doaj   +1 more source

Expression analysis of p16 and TOP2A protein biomarkers in cervical cancer lesions and their correlation with clinico-histopathological characteristics in a referral hospital, Tanzania

PLoS ONE, 2021
Introduction Biomarkers yield important information for early diagnosis of cervical cancer. However, they are rarely applied for prognosis of cervical cancer in Tanzania, where visual inspection assay with acetic acid or Lugol’s iodine and Pap test are ...
Zavuga Zuberi, Alex Mremi, Jaffu O. Chilongola, George Semango, Elingarami Sauli   +4 more
doaj   +2 more sources

p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells [PDF]

Neuro-Oncology, 2012
Deregulation of the p16(INK4a)-Cdk4/6-Rb pathway is commonly detected in patients with glioblastoma multiforme (GBM) and is a rational therapeutic target. Here, we characterized the p16(INK4a)-Cdk4/6-Rb pathway in the Mayo panel of GBM xenografts, established from primary tissue samples from patients with GBM, and evaluated their response to PD0332991,
Ling, Cen, Brett L, Carlson, Mark A, Schroeder, Jamie L, Ostrem, Gaspar J, Kitange, Ann C, Mladek, Stephanie R, Fink, Paul A, Decker, Wenting, Wu, Jung-Sik, Kim, Todd, Waldman, Robert B, Jenkins, Jann N, Sarkaria   +12 more
openaire   +2 more sources

Differentiation of Human Malignant Melanoma Cells that Escape Apoptosis After Treatment with 9-Nitrocamptothecin In Vitro

Neoplasia: An International Journal for Oncology Research, 1999
After in-vitro exposure to 0.05 μmol/L 9-nitrocamptothecin (9NC) for periods of time longer than 5 days, 65% to 80% of the human malignant melanoma SB1 B cells die by apoptosis, whereas the remaining cells are arrested at the G2-phase of the cell cycle ...
Panayotis Pantazis, Devasis Chatterjee, Zhiyong Han, James Wyche   +3 more
doaj   +1 more source

The effect of resveratrol supplementation on the expression levels of factors associated with cellular senescence and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: study protocol for a double-blind controlled randomised clinical trial

BMJ Open, 2019
Introduction Over the past decades, the number of people with type 2 diabetes (T2D) has increased globally. One of the major complications in these patients is cardiovascular disease; it seems that the cell proliferation inhibition can improve vascular ...
Shima Abdollahi, Amin Salehi-Abargouei, Mahtab Tabatabaie, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Masoud Rahmanian, Omid Toupchian, Elham Karimi-Nazari, Hassan Mozaffari-Khosravi   +8 more
doaj   +1 more source

Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs. [PDF]

PLoS ONE, 2014
Epigenetic silencing of tumour suppressor genes has been observed in various cancers. Looking at hepatocellular carcinoma (HCC) specific protein silencing was previously demonstrated to be associated with the Hepatitis C virus (HCV).
Inga Hinrichsen, Matthias Kemp, Jan Peveling-Oberhag, Sandra Passmann, Guido Plotz, Stefan Zeuzem, Angela Brieger   +6 more
doaj   +1 more source

Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression

Biomolecules, 2020
Genetic alterations in the INK4a/ARF (or CDKN2A) locus have been reported in many cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast, and pancreatic cancers.
Zizhen Ming, Su Yin Lim, Helen Rizos
doaj   +1 more source

Histopathological characteristics and coexpression of p53 and p16INK4a proteins in renal cancer [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Renal carcinoma represents histologically heterogeneous group of malignant tumors, with various clinical aggressiveness. The frequency of p53 mutation in primal renal carcinoma is rare, although there are information about its ...
Živković Slađana, Kostov Miloš, Pavlović Svetlana, Mijović Žaklina   +3 more
doaj   +1 more source

The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouse [PDF]

Reproductive Biology and Endocrinology, 2003
Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs).In this study we tested the expression of CDKIs p15, p16, p21 and p27 by immunohistochemistry to determine the role of CDKIs in the initiation of primordial follicle growth.
Bayrak Aykut, Oktay Kutluk
openaire   +3 more sources