Results 11 to 20 of about 16,580 (182)

Oncogenic and Tumor Suppressive Components of the Cell Cycle in Breast Cancer Progression and Prognosis

Pharmaceutics, 2021
Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are propagated toward uncontrolled cell division and proliferation in ...
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee   +4 more
doaj   +1 more source

Immunocytochemical detection of p16INK4a protein for the identification of patients at risk of cervical cancer [PDF]

Archive of Oncology, 2008
Background: p16INK4a, cyclin-dependent kinase inhibitor that inhibits cyclin dependent kinase 4 and 6, is a product of the INK4a gene, involved in the phosphorylation of the retinoblastoma protein (pRB). HPV E7 protein binds specifically to pRB.
Divani Smaroula, Vardouli Anna, Alexopoulou Vana   +2 more
doaj   +1 more source

Simultaneous Analysis of the p16 Gene and Protein in Canine Lymphoma Cells and Their Correlation with pRb Phosphorylation

Veterinary Sciences, 2022
Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest.
Leni Maylina, Satoshi Kambayashi, Kenji Baba, Masaru Okuda   +3 more
doaj   +1 more source

Tissue Microarray Analysis of Cyclin-Dependent Kinase Inhibitors p21 and p16 in Fuchs Dystrophy [PDF]

Cornea, 2013
To investigate the novel application of tissue microarray (TMA) technology to corneal disease and to report altered protein expression of senescence-associated cyclin-dependent kinase inhibitors p21 and p16 in Fuchs endothelial corneal dystrophy (FECD).A TMA including 208 cores was generated from paraffin-embedded tissues, including corneal buttons of ...
Mario, Matthaei, Eva-Maria, Lackner, Huan, Meng, Jessica L, Hicks, Alan K, Meeker, Charles G, Eberhart, Albert S, Jun   +6 more
openaire   +2 more sources

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts [PDF]

Proceedings of the National Academy of Sciences, 1996
Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated.
D A, Alcorta, Y, Xiong, D, Phelps, G, Hannon, D, Beach, J C, Barrett   +5 more
openaire   +2 more sources

Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging

Cells, 2022
A plethora of factors have been attributed to underly aging, including oxidative stress, telomere shortening and cellular senescence. Several studies have shown a significant role of the cyclin-dependent kinase inhibitor p16ink4a in senescence and aging.
Hasan Safwan-Zaiter, Nicole Wagner, Jean-François Michiels, Kay-Dietrich Wagner   +3 more
doaj   +1 more source

Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma [PDF]

Blood, 1995
Abstract B-cell non-Hodgkin's lymphoma (NHL) is a heterogeneous lymphoid malignancy consisting of several histologic types. Alterations in proto-oncogenes caused by reciprocal chromosome translocations have been implicated in the etiology of specific histologic groups.
P R, Koduru, M, Zariwala, M, Soni, J Z, Gong, Y, Xiong, J D, Broome   +5 more
openaire   +3 more sources

Prevalence of HPV Infection and p16^INK4a Overexpression in Surgically Treated Laryngeal Squamous Cell Carcinoma

Vaccines, 2022
Background: The mucosal high-risk (HR) human papillomavirus (HPV) is associated with oropharyngeal carcinogenesis. Aims of this study were to evaluate the prevalence of HR-HPV infection in laryngeal squamous cell carcinoma (LSCC) from different subsites,
Roberto Gallus, Tarik Gheit, Dana Holzinger, Marco Petrillo, Davide Rizzo, Gianluigi Petrone, Francesco Miccichè, Gian Carlo Mattiucci, Damiano Arciuolo, Giampiero Capobianco, Giovanni Delogu, Vincenzo Valentini, Massimo Tommasino, Francesco Bussu   +13 more
doaj   +1 more source

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Genes & Nutrition, 2018
Background Liver is the crucial organ as a hub for metabolic reactions. p16(INK4a) is a well-established cyclin-dependent kinase (CDK) inhibitor that plays important role in the molecular pathways of senescence, which lead to irreversible cell cycle ...
Xiyuan Zhang, Guanying Bianca Xu, Dan Zhou, Yuan-Xiang Pan   +3 more
doaj   +1 more source

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts [PDF]

Molecular and Cellular Biology, 1999
The irreversible G1 arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G1 cyclin-cyclin-dependent kinase (Cdk) complexes responsible for phosphorylation of the retinoblastoma protein (pRb). We show that the Cdk inhibitor p21(Sdi1,Cip1,Waf1), which accumulates progressively in aging cells, binds to and inactivates ...
Stein, Gretchen, Drullinger, Linda, Soulard, Alexandre, Dulić, Vjekoslav   +3 more
openaire   +3 more sources