Results 11 to 20 of about 16,725 (189)

Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma

Pathology - Research and Practice, 2021
Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (
Sofija Glumac, Radoslav Davidovic, Branko Dozic, Sasa Hinic, Ivan Pavlovic, Dunja Drakulic, Ana Todorović, Maja Medojevic Pavlovic, Sanja Radojevic Skodric, Ivana Baralic, Jelena Sopta, Snezana Pejic   +11 more
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Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase [PDF]

Journal of Biological Chemistry, 1995
Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals.
O, Aprelikova, Y, Xiong, E T, Liu
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Tissue Microarray Analysis of Cyclin-Dependent Kinase Inhibitors p21 and p16 in Fuchs Dystrophy [PDF]

Cornea, 2013
To investigate the novel application of tissue microarray (TMA) technology to corneal disease and to report altered protein expression of senescence-associated cyclin-dependent kinase inhibitors p21 and p16 in Fuchs endothelial corneal dystrophy (FECD).A TMA including 208 cores was generated from paraffin-embedded tissues, including corneal buttons of ...
Mario, Matthaei, Eva-Maria, Lackner, Huan, Meng, Jessica L, Hicks, Alan K, Meeker, Charles G, Eberhart, Albert S, Jun   +6 more
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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts [PDF]

Proceedings of the National Academy of Sciences, 1996
Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated.
D A, Alcorta, Y, Xiong, D, Phelps, G, Hannon, D, Beach, J C, Barrett   +5 more
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Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma [PDF]

Blood, 1995
Abstract B-cell non-Hodgkin's lymphoma (NHL) is a heterogeneous lymphoid malignancy consisting of several histologic types. Alterations in proto-oncogenes caused by reciprocal chromosome translocations have been implicated in the etiology of specific histologic groups.
P R, Koduru, M, Zariwala, M, Soni, J Z, Gong, Y, Xiong, J D, Broome   +5 more
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Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts [PDF]

Molecular and Cellular Biology, 1999
The irreversible G1 arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G1 cyclin-cyclin-dependent kinase (Cdk) complexes responsible for phosphorylation of the retinoblastoma protein (pRb). We show that the Cdk inhibitor p21(Sdi1,Cip1,Waf1), which accumulates progressively in aging cells, binds to and inactivates ...
Stein, Gretchen, Drullinger, Linda, Soulard, Alexandre, Dulić, Vjekoslav   +3 more
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Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies

Oncology Reports, 2006
The p16 protein is a cyclin-dependent kinase (CDK) inhibitor, which plays an important role in the regulation of the cell cycle by inactivating the cyclin-dependent kinase (CDK) that phosphorylates the retinoblastoma (Rb) protein. Overexpression of p16 protein has been found in many types of human malignancy.
Looi, Koksun, Megliorino, Roxanne, Shi, Fu-Dong, Peng, Xuan-Xian, Chen, Yao, Zhang, Jian-Ying   +5 more
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Expression analysis of p16 and TOP2A protein biomarkers in cervical cancer lesions and their correlation with clinico-histopathological characteristics in a referral hospital, Tanzania

PLoS ONE, 2021
Introduction Biomarkers yield important information for early diagnosis of cervical cancer. However, they are rarely applied for prognosis of cervical cancer in Tanzania, where visual inspection assay with acetic acid or Lugol’s iodine and Pap test are ...
Zavuga Zuberi, Alex Mremi, Jaffu O. Chilongola, George Semango, Elingarami Sauli   +4 more
doaj   +2 more sources

Differentiation of Human Malignant Melanoma Cells that Escape Apoptosis After Treatment with 9-Nitrocamptothecin In Vitro

Neoplasia: An International Journal for Oncology Research, 1999
After in-vitro exposure to 0.05 μmol/L 9-nitrocamptothecin (9NC) for periods of time longer than 5 days, 65% to 80% of the human malignant melanoma SB1 B cells die by apoptosis, whereas the remaining cells are arrested at the G2-phase of the cell cycle ...
Panayotis Pantazis, Devasis Chatterjee, Zhiyong Han, James Wyche   +3 more
doaj   +1 more source

p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells [PDF]

Neuro-Oncology, 2012
Deregulation of the p16(INK4a)-Cdk4/6-Rb pathway is commonly detected in patients with glioblastoma multiforme (GBM) and is a rational therapeutic target. Here, we characterized the p16(INK4a)-Cdk4/6-Rb pathway in the Mayo panel of GBM xenografts, established from primary tissue samples from patients with GBM, and evaluated their response to PD0332991,
Ling, Cen, Brett L, Carlson, Mark A, Schroeder, Jamie L, Ostrem, Gaspar J, Kitange, Ann C, Mladek, Stephanie R, Fink, Paul A, Decker, Wenting, Wu, Jung-Sik, Kim, Todd, Waldman, Robert B, Jenkins, Jann N, Sarkaria   +12 more
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