Results 11 to 20 of about 3,597,789 (164)

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: Possible implications for melanoma progression [PDF]

JNCI Journal of the National Cancer Institute, 2003
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: Possible implications for melanoma ...
VC Gray-Schopfer (21429866), NP Smit (21429869), L Hill (9866732), D Kipling (21429872), Tracy Evans-Whipp (15902936), J Bond (7643015), V Bataille (13370688), DC Bennett (16084832), EV Sviderskaya (21429851), SP Hill (21429854), G Peters (13279506), D Wynford-Thomas (13701919)   +11 more
core   +3 more sources

The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. [PDF]

, 2011
Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Hassan, Moustapha, Sallam, Hatem, Hassan, Zuzana   +2 more
core   +4 more sources

Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma

Pathology - Research and Practice, 2021
Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (
Sofija Glumac, Radoslav Davidovic, Branko Dozic, Sasa Hinic, Ivan Pavlovic, Dunja Drakulic, Ana Todorović, Maja Medojevic Pavlovic, Sanja Radojevic Skodric, Ivana Baralic, Jelena Sopta, Snezana Pejic   +11 more
openaire   +3 more sources

Tissue Microarray Analysis of Cyclin-Dependent Kinase Inhibitors p21 and p16 in Fuchs Dystrophy [PDF]

Cornea, 2013
To investigate the novel application of tissue microarray (TMA) technology to corneal disease and to report altered protein expression of senescence-associated cyclin-dependent kinase inhibitors p21 and p16 in Fuchs endothelial corneal dystrophy (FECD).A TMA including 208 cores was generated from paraffin-embedded tissues, including corneal buttons of ...
Mario, Matthaei, Eva-Maria, Lackner, Huan, Meng, Jessica L, Hicks, Alan K, Meeker, Charles G, Eberhart, Albert S, Jun   +6 more
openaire   +2 more sources

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts [PDF]

Proceedings of the National Academy of Sciences, 1996
Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated.
D A, Alcorta, Y, Xiong, D, Phelps, G, Hannon, D, Beach, J C, Barrett   +5 more
openaire   +2 more sources

Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma [PDF]

Blood, 1995
Abstract B-cell non-Hodgkin's lymphoma (NHL) is a heterogeneous lymphoid malignancy consisting of several histologic types. Alterations in proto-oncogenes caused by reciprocal chromosome translocations have been implicated in the etiology of specific histologic groups.
P R, Koduru, M, Zariwala, M, Soni, J Z, Gong, Y, Xiong, J D, Broome   +5 more
openaire   +3 more sources

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]

, 2011
Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G., Brown, Elaine, Thomson, Graeme, Blake, David G., Malone, Kirk, Turner, Nicholas J., Grant, Karen, Mottram, Jeremy C., Walkinshaw, Malcolm D., Nowicki, Matthew W.   +9 more
core   +3 more sources

Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]

, 2006
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Popp, Oliver, Nalabothula, Narasimharao, Gil-Parrado, S., Jochum, M., Ghosh, M., Machleidt, W., Machleidt, Werner, Ghosh, Madhumita, Gil-Parrado, Shirley, Holak, Tad A., Joy, J., Joy, Joma, Holak, T. A., Jochum, Marianne, Popp, O., Nalabothula, N.   +15 more
core   +1 more source

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Mayer, Bettina A., Nina Berberich, Stefan Zahler, Sass, Gabriele, Fritz Krombach, Vollmar, Angelika M., Tiegs, Gisa, Krombach, Fritz, Fürst, Robert, Robert Fürst, Totzke, Frank, Angelika M. Vollmar, Jos Joore, Gisa Tiegs, Berberich, Nina, Alexander G. Khandoga, Bettina A. Mayer, Joore, Jos, Ulrike K. Schmerwitz, Gabriele Sass, Zahler, Stefan, Frank Totzke, Schmerwitz, Ulrike K., Khandoga, Alexander G.   +23 more
core   +1 more source

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts [PDF]

Molecular and Cellular Biology, 1999
The irreversible G1 arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G1 cyclin-cyclin-dependent kinase (Cdk) complexes responsible for phosphorylation of the retinoblastoma protein (pRb). We show that the Cdk inhibitor p21(Sdi1,Cip1,Waf1), which accumulates progressively in aging cells, binds to and inactivates ...
Stein, Gretchen, Drullinger, Linda, Soulard, Alexandre, Dulić, Vjekoslav   +3 more
openaire   +3 more sources