Results 291 to 300 of about 217,248 (344)

Adenosine (P1) receptor signalling

Drug Development Research, 1996
The coupling of the four defined types of adenosine receptors to G proteins and the consequent activation of effector pathways is briefly summarized. It is pointed out that the G proteins are able to influence many types of cellular effector systems, and, in particular, that the a and the β,γ-subunits may activate different signalling pathways that may
Bertil B. Fredholm, Giulia Arslan, Bj�rn Kull, Ewa Kontny, Per Svenningsson   +4 more
openaire   +1 more source

ATP-stimulated ANP release through P1 receptor subtype

Regulatory Peptides, 2005
Extracellular ATP acts as a local regulator of physiological functions in the cardiovascular system via P1 and P2 receptors. However, little is known about the effect of ATP on the release of atrial natriuretic peptide (ANP) secretion. The purpose of this study was to investigate the effects of extracellular ATP on atrial hemodynamics and ANP release ...
Chunhua, Cao, Feng Lian, Piao, Jeong Hee, Han, Sung Zoo, Kim, Suhn Hee, Kim   +4 more
openaire   +2 more sources

Molecular architecture of mouse activating NKR-P1 receptors

Journal of Structural Biology, 2011
Receptors belonging to NKR-P1 family and their specific Clr ligands form an alternative missing self recognition system critical in immunity against tumors and viruses, elimination of tumor cells subjected to genotoxic stress, activation of T cell dependent immune response, and hypertension.
Petr, Kolenko, Daniel, Rozbeský, Ondřej, Vaněk, Vladimír, Kopecký, Kateřina, Hofbauerová, Petr, Novák, Petr, Pompach, Jindřich, Hašek, Tereza, Skálová, Karel, Bezouška, Jan, Dohnálek   +10 more
openaire   +2 more sources

P1- and P2-purine receptors in brain circulation

European Journal of Pharmacology, 1987
As there is increasing evidence that purines are involved in cerebral vasodilatation, purine receptors were characterized pharmacologically in pial arteries from rabbit, cat and man, and compared with purine receptors in various non-cerebral vascular beds.
J E, Hardebo, J, Kåhrström, C, Owman
openaire   +2 more sources

New Heterocyclic Ligands for the Adenosine Receptors P1 and for the ATP Receptors P2

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
BARALDI, Pier Giovanni, ROMAGNOLI, Romeo, AGHAZADEH TABRIZI, Mojgan, BOVERO, Andrea, PRETI, Delia, FRUTTAROLO, Francesca, Moorman AR, BOREA, Pier Andrea   +7 more
openaire   +5 more sources

P1 Receptors in the Cardiovascular System

2001
The presence of adenosine receptors on cardiovascular tissues has previously been established on the basis of functional responses to adenosine and adenosine analogs. Specific functions attributed to each of the four adenosine receptor subtypes (A1, A2A, A2B, and A3) are discussed in detail below following a summary of the direct evidence for adenosine
R.M. Broad, Joel Linden
openaire   +1 more source

P1 Receptors in the Respiratory System

2001
In this chapter the role of adenosine receptors in the modulation respiratory system is reviewed. The chapter is divided into sections based on the effects of adenosine receptors on the different aspects of pulmonary physiology. The potential role of PI purinergic receptors in the regulation of epithelial and endothelial function, ventilatory drive ...
I. Biaggioni, I. Feoktistov
openaire   +1 more source

Impact of Ectoenzymes on P2 and P1 Receptor Signaling

2011
P2 receptors that are activated by extracellular nucleotides (e.g., ATP, ADP, UTP, UDP, Ap(n)A) and P1 receptors activated by adenosine control a diversity of biological processes. The activation of these receptors is tightly regulated by ectoenzymes that metabolize their ligands.
Filip, Kukulski, Sébastien A, Lévesque, Jean, Sévigny   +2 more
openaire   +2 more sources

Modulating P1 Adenosine Receptors in Disease Progression of SOD1G93A Mutant Mice

Neurochemical Research, 2019
Amyotrophic lateral sclerosis (ALS) is a fatal progressing neurodegenerative disease; to date, despite the intense research effort, only two therapeutic options, with very limited effects, are available. The purinergic system has been indicated as a possible new therapeutic target for ALS, but the results are often contradictory and generally confused.
Monica Armida, Alessandra Matteucci, Antonella Pèzzola, Younis Baqi, Christa E. Müller, Patrizia Popoli, Rosa Luisa Potenza   +6 more
openaire   +2 more sources

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

Glia, 2012
AbstractMicroglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y12 receptors, they are transformed into a moving phenotype, showing process extension and migration ...
Schuichi, Koizumi, Keiko, Ohsawa, Kazuhide, Inoue, Shinichi, Kohsaka   +3 more
openaire   +2 more sources