Results 301 to 310 of about 217,248 (344)
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Abstract P1-07-09: Estrogen receptor positivity: 10% or 1%?
Cancer Research, 2012Abstract Background. Guidelines by the American Society of Clinical Oncology and the College of American Pathologists recently recommended that estrogen receptor (ER) status should be considered positive if 1% of tumor cells demonstrate positive nuclear staining by immunohistochemistry.
M Yi +11 more
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P1 and P2 Receptors in Platelets
2001Because of the importance of platelets in haemostasis and thrombosis, these cell fragments have been extensively studied for many years and the existence of receptors for adenosine and adenine nucleotides on platelets has been recognised since the early 1960s.
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P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes
Journal of Applied Physiology, 1989Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP ...
D, Warburton, S, Buckley, L, Cosico
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Abstract P1-05-03: Isoform specific targeting of insulin receptor
Cancer Research, 2019Abstract The insulin receptor (InsR) exists in both an A and B isoform. InsR-B differs from InsR-A by the inclusion of exon 11, which encodes 12 amino acid residues at the C-terminus of the InsR alpha-subunit. Increased InsR-A expression is associated with mitogenic signaling pathways while InsR-B is linked to insulin-mediated metabolic ...
K LaPara +6 more
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Activation of the mouse heart adenosine 5',5'''-P1-P4-tetraphosphate receptor
Biochemistry, 1993We have previously demonstrated that mouse brain membrane fractions have a specific, saturable receptor for diadenylated nucleotides. Binding is specific for two adenosines, and the length of the phosphate bridge is critical, with four phosphates being optimal [Hilderman et al. (1991) J. Biol. Chem. 266, 6915-6918].
J, Walker +3 more
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Selective inhibition of low affinity IgE receptor (CD23) processing: P1′ bicyclomethyl substituents
Bioorganic & Medicinal Chemistry Letters, 1999Using a variety of alpha-hydroxy hydroxamic acid derivatives, the size and shape of the S1' pocket for the CD23 processing metalloprotease has been explored. It has been demonstrated that a P1' 2-naphthylmethyl group occupies most of the available space and gives excellent selectivity against fibroblast collagenase (matrix metalloproteinase-1, MMP-1 ...
S, Bailey +10 more
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P1 and P2 receptors in cell growth and differentiation
Drug Development Research, 1996Besides their well-established roles as short-term neurotransmitters, nucleotides and nucleosides are also potent regulators of cell growth and differentiation. Compelling evidence obtained on neural, immune, cardiovascular and respiratory system cells, as well as on many other cell types, suggests that these compounds may act as physiological ...
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Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.
International Journal of Oncology, 2000Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. Recombinantly prepared soluble form of rat NKR-P1 (CD161) recognized carbohydrate GalNac and GlcNac moieties. Ganglioside GM2 and heparin related-IS oligosaccharides representing the high affinity ligands for this receptor, increased the ...
M, Pospisil +6 more
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P1 and P2 Receptors in the Renal System
2001Modulation of the function of excretory organs by purine receptors is an ancient regulatory strategy adopted early in the course of vertebrate evolution. For instance, in the shark rectal gland, an excretory organ that evolved more than 400 million years ago, primordial adenosine receptors strongly influence the rate of sodium chloride transport and ...
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P1-/P2-purinergic receptors on cultured rabbit retinal Müller cells.
Japanese journal of ophthalmology, 1998Adenosine 5'-triphosphate (ATP) and its metabolic products function as neurotransmitters or neuromodulators under the control of P1/P2-purinergic receptors. To determine the presence of these receptors on retinal Müller cells, spectrofluorometry was carried out on intracellular calcium mobilization, using Fura-2 images.
Y, Liu, M, Wakakura
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