Results 311 to 320 of about 204,366 (349)

Extracellular ATP, P2 receptors, and inflammation

Drug Development Research, 2003
AbstractOver the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the ...
Di Virgilio F., Ferrari D., Idzko M., Panther E., Norgauer J., La Sala A., Girolomoni G.   +6 more
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The P2 Receptors

2017
Adenine nucleotides (ADP and ATP) play crucial roles in the physiological process of primary hemostasis and in the development and extension of arterial thrombosis. They act on platelets through three distinct P2 receptors: the P2Y1 and P2Y12 receptors, which are G protein-coupled ADP receptors and the P2X1 receptor, a ligand-gated cation channel ...
Béatrice Hechler, Christian Gachet
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The Platelet P2 Receptors in Thrombosis

Seminars in Thrombosis and Hemostasis, 2005
Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) play a crucial role in hemostasis and thrombosis, and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X (1) and the two G protein-coupled P2Y (1) and P2Y (12) ADP receptors selectively contribute to platelet aggregation.
Christian, Gachet, Béatrice, Hechler
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The P2 Receptors in Platelet Function

Seminars in Thrombosis and Hemostasis, 2005
After vessel wall injury, platelets adhere to the exposed subendothelium, are activated, and release mediators such as thromboxane A (2) (TXA (2)) and nucleotides stored at very high concentration in the so-called dense granules. Among other soluble agents, released nucleotides act in a positive feedback mechanism to cause further platelet activation ...
Béatrice, Hechler, Marco, Cattaneo, Christian, Gachet   +2 more
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P2 nucleotide receptors in osteoclasts

Drug Development Research, 2001
AbstractOsteoclasts are large, multinucleated cells responsible for the resorption of bone and other mineralized tissues. Whereas low concentrations of extracellular ATP stimulate osteoclast formation and resorptive activity, high concentrations inhibit osteoclast formation.
Lin N. Naemsch, Xiaobing Du, Stephen M. Sims, S. Jeffrey Dixon   +3 more
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The platelet P2 receptors in inflammation

Hämostaseologie, 2015
SummaryIn addition to their well characterized and established role in haemostasis and thrombosis, platelets contribute to the pathogenesis of inflammation. Adenine nucleotides are signalling molecules that regulate the function of virtually every cell in the body, by interacting with P2 receptors.
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P2-Pyrimidinergic Receptors and Their Ligands

Current Pharmaceutical Design, 2002
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14).
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P2 receptors in the murine gastrointestinal tract

Neuropharmacology, 2002
The actions of adenosine, adenosine 5'-triphosphate (ATP), 2-methylthio adenosine diphosphate ADP (2-MeSADP), 2-methylthio ATP (2-MeSATP), alpha,beta-methylene ATP (alpha,beta-meATP) and uridine triphosphate (UTP) on isolated segments of mouse stomach (fundus), duodenum, ileum and colon were investigated. The localization of P2Y(1), P2Y(2), P2Y(4), P2X(
GIARONI, CRISTINA, KNIGHT G. E., RUAN H. Z., GLASS R., BARDINI M., LECCHINI, SERGIO, FRIGO, GIANMARIO, BURNSTOCK G.   +7 more
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The platelet P2 receptors in arterial thrombosis

Blood Cells, Molecules, and Diseases, 2006
ADP and ATP play a crucial role in hemostasis and thrombosis and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X1 and the two G protein-coupled P2Y1 and P2Y12 ADP receptors selectively contribute to platelet aggregation.
Christian, Gachet, Catherine, Léon, Béatrice, Hechler   +2 more
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The P2 Nucleotide Receptors

1998
Part I. Historical Perspectives of P2 Nucleotide Receptors. History of Extracellular Nucleotides and Their Receptors, G. Burnstock. Part II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors. P2x Receptors: Cloned and Expressed, R. J. Evans, A. Surprenant, and R. A. North.
openaire   +1 more source