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REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS
Annual Review of Pharmacology and Toxicology, 2006▪ Abstract The main role of blood platelets is to ensure primary hemostasis, which is the maintenance of vessel integrity and cessation of bleeding upon injury. While playing a major part in acute arterial thrombosis, platelets are also involved in inflammation, atherosclerosis, and angiogenesis. ADP and ATP play a crucial role in platelet activation,
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1998
Extracellular purines and pyrimidines regulate blood flow by important effects on vascular tone mediated via cell surface P2 receptors. P2 receptors are divided into two superfamilies, P2X and P2Y, according to whether they are ligand-gated cation channels or are coupled to G proteins respectively.
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Extracellular purines and pyrimidines regulate blood flow by important effects on vascular tone mediated via cell surface P2 receptors. P2 receptors are divided into two superfamilies, P2X and P2Y, according to whether they are ligand-gated cation channels or are coupled to G proteins respectively.
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P2 receptors, platelet function and pharmacological implications
Thrombosis and Haemostasis, 2008SummaryADP and ATP play a crucial role in platelet activation and their receptors are potential targets for antithrombotic drugs. The ATP-gated cation channel P2X1 and the two G protein-coupled ADP receptors, P2Y1 and P2Y12, selectively contribute to platelet aggregation and formation of a thrombus.Owing to its central role in the growth and ...
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly
Current treatment and recent progress in gastric cancer
Ca-A Cancer Journal for Clinicians, 2021Smita S Joshi, Brian D Badgwell
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A review of cancer immunotherapy toxicity
Ca-A Cancer Journal for Clinicians, 2020Lucy Boyce Kennedy
exaly