Advanced Science, EarlyView.Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen +14 more
wiley +1 more source
Involvement of P2 receptors in hematopoiesis and hematopoietic disorders, and as pharmacological targets. [PDF]
Purinergic Signal, 2020 Filippin KJ +7 more
europepmc +1 more source
Multiple P2 Receptors Contribute to a Transient Increase in Intracellular Ca2+ Concentration in Atp‐Stimulated Rat Brown Adipocytes [PDF]
, 2002 Mariko Omatsu‐Kanbe +2 more
openalex +1 more source
Advanced Science, EarlyView.A bioluminescent probe, BLGLN, comprising BL568 and ASCT2‐uptaken AA201, enables real‐time monitoring and evaluation of ASCT2‐mediated glutamine uptake rates in living tumors via Staudinger ligation, aiding tumor metabolism studies and targeted therapeutics.
Bing‐Jun Zhou +9 more
wiley +1 more source
P2Y12 receptor gene mutations associated with bleeding
Platelets, 2017 Mariangela Scavone +2 more
doaj +1 more source
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices [PDF]
, 2003 Teresa Almeida +4 more
openalex +1 more source
Engineered Anti‐Senescence Trachea With Post‐Transplanted Regenerative Homeostasis
Advanced Science, EarlyView.Bioengineered trachea undergoes post‐transplanted senescence, which is found in this study for the first time. Hebe‐ET is designed with dual anti‐senescence strategies: fiber‐film scaffold in cartilage rings for close‐packed cell interaction, and quercetin‐loaded fibrous rings for immune modulation.
Ziyin Pan +14 more
wiley +1 more source
P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells
, 1998 Stine F. Pedersen +3 more
openalex +1 more source
The Receptor Binding Protein P2 of PRD1, a Virus Targeting Antibiotic-Resistant Bacteria, Has a Novel Fold Suggesting Multiple Functions [PDF]
, 2003 Lan Xu +4 more
openalex +1 more source
Advanced Science, EarlyView.Lyophilization is a key process used in the production of biotherapeutic products. This article reviews and discusses the application of HSI on lyophilization, and the strategies that use the resulting data to build models. It is intended to provide guidance and insights for non‐specialist researchers and engineers into leveraging HSI and the data ...
Huiwen Yu +5 more
wiley +1 more source