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P2 receptors meet the immune system
Trends in Pharmacological Sciences, 2001Abstract The 1st International Workshop on Nucleotides and their Receptors in the Immune System was held on 8–10 September 2000 at the University of Ferrara, Ferrara, Italy.
DI VIRGILIO, Francesco +2 more
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The platelet P2 receptors in arterial thrombosis
Blood Cells, Molecules, and Diseases, 2006ADP and ATP play a crucial role in hemostasis and thrombosis and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X1 and the two G protein-coupled P2Y1 and P2Y12 ADP receptors selectively contribute to platelet aggregation.
Béatrice Hechler +2 more
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Salivary Gland P2 Nucleotide Receptors
Critical Reviews in Oral Biology & Medicine, 1999The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland ...
J.T. Turner +3 more
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P2 Receptors in the Cardiovascular System
2001It is now well established that purine nucleotides play a complex regulatory role in the cardiovascular system (Boarder and Hovrani 1998). ATP exerts multiple effects on endothelial cells, platelets, perivascular nerves, vascular smooth muscle cells and cardiac myocytes (Pearson and Gordon 1989; Boarder and Hovrani 1998; Pelleg and Belardinelli 1998 ...
Amir Pelleg, G. Vassort
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REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS
Annual Review of Pharmacology and Toxicology, 2006▪ Abstract The main role of blood platelets is to ensure primary hemostasis, which is the maintenance of vessel integrity and cessation of bleeding upon injury. While playing a major part in acute arterial thrombosis, platelets are also involved in inflammation, atherosclerosis, and angiogenesis. ADP and ATP play a crucial role in platelet activation,
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The discovery and development of P2 receptor subtypes
Journal of the Autonomic Nervous System, 2000Extracellular purine and pyrimidine nucleotides modulate cellular activity by acting at P2 receptors. The first receptor to be identified was the P(2)-purinoceptor, which was characterised and named in 1978. In the 1980s this site was subdivided into P(2X) and P(2Y) purinoceptors on the basis of pharmacological criteria in functional studies on native ...
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3 The Medicinal Chemistry of the P2 Receptor Family
2001Publisher Summary This chapter reviews that the purinoreceptors are a family of receptors that are activated by nucleosides and nucleotides. The purinoreceptors is divided into two families: The P 1 receptors, where nucleosides are more active than nucleotides and the P 2 receptors, where nucleotides are more active than nucleosides.
Nicholas Kindon +5 more
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1998
Extracellular purines and pyrimidines regulate blood flow by important effects on vascular tone mediated via cell surface P2 receptors. P2 receptors are divided into two superfamilies, P2X and P2Y, according to whether they are ligand-gated cation channels or are coupled to G proteins respectively.
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Extracellular purines and pyrimidines regulate blood flow by important effects on vascular tone mediated via cell surface P2 receptors. P2 receptors are divided into two superfamilies, P2X and P2Y, according to whether they are ligand-gated cation channels or are coupled to G proteins respectively.
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P2 Receptors in the Respiratory System
2001As in other tissues, it is now well established that nucleotides are released into the extracellular fluid of the respiratory tract during normal homeostatic as well as pathologic conditions to act on cell surface P2 purinergic receptors. Both the ligand gated ion channel P2X subtype and the G-protein coupled P2Y subtype have been identified and shown ...
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P1 and P2 Receptors in Platelets
2001Because of the importance of platelets in haemostasis and thrombosis, these cell fragments have been extensively studied for many years and the existence of receptors for adenosine and adenine nucleotides on platelets has been recognised since the early 1960s.
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