Results 291 to 300 of about 135,603 (303)
Some of the next articles are maybe not open access.
P2-Pyrimidinergic Receptors and Their Ligands
Current Pharmaceutical Design, 2002Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14).
openaire +2 more sources
P2 receptors in the murine gastrointestinal tract
Neuropharmacology, 2002The actions of adenosine, adenosine 5'-triphosphate (ATP), 2-methylthio adenosine diphosphate ADP (2-MeSADP), 2-methylthio ATP (2-MeSATP), alpha,beta-methylene ATP (alpha,beta-meATP) and uridine triphosphate (UTP) on isolated segments of mouse stomach (fundus), duodenum, ileum and colon were investigated. The localization of P2Y(1), P2Y(2), P2Y(4), P2X(
GIARONI, CRISTINA +7 more
openaire +3 more sources
The platelet P2 receptors in arterial thrombosis
Blood Cells, Molecules, and Diseases, 2006ADP and ATP play a crucial role in hemostasis and thrombosis and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X1 and the two G protein-coupled P2Y1 and P2Y12 ADP receptors selectively contribute to platelet aggregation.
Christian, Gachet +2 more
openaire +2 more sources
1998
Part I. Historical Perspectives of P2 Nucleotide Receptors. History of Extracellular Nucleotides and Their Receptors, G. Burnstock. Part II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors. P2x Receptors: Cloned and Expressed, R. J. Evans, A. Surprenant, and R. A. North.
openaire +1 more source
Part I. Historical Perspectives of P2 Nucleotide Receptors. History of Extracellular Nucleotides and Their Receptors, G. Burnstock. Part II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors. P2x Receptors: Cloned and Expressed, R. J. Evans, A. Surprenant, and R. A. North.
openaire +1 more source
REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS
Annual Review of Pharmacology and Toxicology, 2006▪ Abstract The main role of blood platelets is to ensure primary hemostasis, which is the maintenance of vessel integrity and cessation of bleeding upon injury. While playing a major part in acute arterial thrombosis, platelets are also involved in inflammation, atherosclerosis, and angiogenesis. ADP and ATP play a crucial role in platelet activation,
openaire +2 more sources
1998
Extracellular purines and pyrimidines regulate blood flow by important effects on vascular tone mediated via cell surface P2 receptors. P2 receptors are divided into two superfamilies, P2X and P2Y, according to whether they are ligand-gated cation channels or are coupled to G proteins respectively.
openaire +1 more source
Extracellular purines and pyrimidines regulate blood flow by important effects on vascular tone mediated via cell surface P2 receptors. P2 receptors are divided into two superfamilies, P2X and P2Y, according to whether they are ligand-gated cation channels or are coupled to G proteins respectively.
openaire +1 more source
P2 receptors, platelet function and pharmacological implications
Thrombosis and Haemostasis, 2008SummaryADP and ATP play a crucial role in platelet activation and their receptors are potential targets for antithrombotic drugs. The ATP-gated cation channel P2X1 and the two G protein-coupled ADP receptors, P2Y1 and P2Y12, selectively contribute to platelet aggregation and formation of a thrombus.Owing to its central role in the growth and ...
openaire +2 more sources