Results 61 to 70 of about 56,235 (293)

An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research

Advanced Healthcare Materials, EarlyView.
Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs, Alexander Stoegner, Mateo G. Vasconez Martínez, Markus M. Schreiner, Melanie Cezanne, Ruth Gruebl‐Barabas, Bettina Rodriguez‐Molina, Juergen Alphonsus, Silvia Hayer, Richard Lass, Iris Gerner, Florien Jenner, Wolfgang Holnthoner, Stefan Toegel, Peter Ertl, Hans P. Kiener, Reinhard Windhager, Mario Rothbauer   +17 more
wiley   +1 more source

Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction

Neurobiology of Disease, 2021
Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR).
Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang-Fan Chen, Paula M. Canas, Rodrigo A. Cunha   +11 more
doaj  

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin, Peter R. Thorne, Gary D. Housley, Srdjan M. Vlajkovic   +3 more
doaj   +1 more source

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

Neural Regeneration Research
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss, Christine Heuer, Marina Herwerth   +2 more
doaj   +1 more source

Recent Advances in Wide‐Bandgap Perovskite Solar Cells

Advanced Materials, EarlyView.
Ubiquitous defects predominately account for photo‐instability and open‐circuit voltage losses in wide‐bandgap perovskite solar cells (WBG PSCs). This review comprehensively presents the underlying impact mechanisms, summarizes the advanced optimization strategies across various functional layers and their interfaces to develop efficient and stable WBG
Jianjun Mei, Feng Yan
wiley   +1 more source

ATP, P2 receptors and the renal microcirculation [PDF]

Purinergic Signalling, 2009
Purinoceptors are rapidly becoming recognised as important regulators of tissue and organ function. Renal expression of P2 receptors is broad and diverse, as reflected by the fact that P2 receptors have been identified in virtually every major tubular/vascular element.
openaire   +3 more sources

Over Tenfold Increase in Current Amplification Due to Anisotropic Polymer Chain Alignment in Organic Electrochemical Transistors

Advanced Materials, EarlyView.
How to boost the IDS output of an OECT? Anisotropic polymer alignment along the channel direction enables a 13‐fold increase in IDS. Such channel engineering opens the door to unprecedented signal amplification (here gmL/Wd = 2 580 S cm−1 with a PBTTT‐backbone bearing single‐ether side chains), faster ON/OFF switching, and improved stability for the ...
Olivier Bardagot, Pablo Durand, Shubhradip Guchait, Han‐Yan Wu, Isabelle Heinzen, Wissal Errafi, Victor Bouylout, Alessandra Pistillo, Chi‐Yuan Yang, Gonzague Rebetez, Priscila Cavassin, Badr Jismy, Julien Réhault, Simone Fabiano, Martin Brinkmann, Nicolas Leclerc, Natalie Banerji   +16 more
wiley   +1 more source

P2 receptor web: Complexity and fine-tuning [PDF]

Pharmacology & Therapeutics, 2006
The present review offers a new perspective on a family of receptors, termed P2 receptors, specific for nucleoside tri- and diphosphates of purines/pyrimidines. We emphasize here that while decoding the inputs of various related extracellular ligands, P2 receptors are a clear example of increasing biological complexity.
Volonté, Cinzia, Amadio, Susanna, D'Ambrosi, Nadia, Colpi, Monica, Burnstock, Geoffrey   +4 more
openaire   +4 more sources