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Molecular physiology of P2X receptors.
Physiological Reviews, 2002P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40–50% identical in amino acid sequence. Each subunit has two transmembrane domains, separated by an extracellular domain (∼280 amino acids). Channels form as multimers of several subunits.
R. North
semanticscholar +4 more sources
Advances in Experimental Medicine and Biology, 2017
Extracellular ATP-gated P2X receptors are trimeric non-selective cation channels important for many physiological events including immune response and neural transmission. These receptors belong to a unique class of ligand-gated ion channels composed of only six transmembrane helices and a relatively small extracellular domain that harbors three ATP ...
T. Kawate
semanticscholar +3 more sources
Extracellular ATP-gated P2X receptors are trimeric non-selective cation channels important for many physiological events including immune response and neural transmission. These receptors belong to a unique class of ligand-gated ion channels composed of only six transmembrane helices and a relatively small extracellular domain that harbors three ATP ...
T. Kawate
semanticscholar +3 more sources
P2X receptors and inflammation.
Current Medicinal Chemistry, 2015Until recently, P2X receptors have not received much attention in the context of immunology and inflammation. While this is justified to a certain extent for P2X1, P2X2, P2X3, P2X5 and P2X6, which still await identification of a convincing role in the pathophysiology of immune cells, it is clearly not any more the case for P2X4 and even more so for ...
F. Virgilio
semanticscholar +4 more sources
Recent progress in the structural biology of P2X receptors
Proteins: Structure, Function, and Bioinformatics, 2022P2X receptors are ATP‐gated trimeric nonselective cation channels that are important for various physiological and pathological processes, including synaptic transmission, pain perception, immune regulation, and apoptosis.
Danqi Sheng, M. Hattori
semanticscholar +1 more source
Current Opinion in Neurobiology, 2001
Over the past two years, ATP has clearly been shown to act as a co-transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacology, stoichiometry and subunit combinations of heteropolymeric P2X channels has been substantially elucidated.
Robertson, SJ +3 more
openaire +3 more sources
Over the past two years, ATP has clearly been shown to act as a co-transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacology, stoichiometry and subunit combinations of heteropolymeric P2X channels has been substantially elucidated.
Robertson, SJ +3 more
openaire +3 more sources
Current Medicinal Chemistry, 2015
Diabetes is a metabolic disorder characterized by elevation of glucose levels in the blood that develops in humans as a result of genetic predisposition and environmental factors. Unbalanced glycemic control has been associated with the development of progressive and debilitating complications that dramatically affect the quality of life and life ...
C. Fotino +3 more
openaire +2 more sources
Diabetes is a metabolic disorder characterized by elevation of glucose levels in the blood that develops in humans as a result of genetic predisposition and environmental factors. Unbalanced glycemic control has been associated with the development of progressive and debilitating complications that dramatically affect the quality of life and life ...
C. Fotino +3 more
openaire +2 more sources
2018
Abstract P2X receptors are ATP-gated ion channels that are ubiquitously expressed in eukaryotic tissues. They are involved in diverse physiological processes, from modulation of synaptic transmission, to inflammation, sensing of taste, bladder filling, and pain.
Ligia Subitoni Antonio, Terrance M. Egan
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Abstract P2X receptors are ATP-gated ion channels that are ubiquitously expressed in eukaryotic tissues. They are involved in diverse physiological processes, from modulation of synaptic transmission, to inflammation, sensing of taste, bladder filling, and pain.
Ligia Subitoni Antonio, Terrance M. Egan
openaire +2 more sources