Results 131 to 140 of about 11,033 (176)
Some of the next articles are maybe not open access.
Molecular Physiology of P2X Receptors
Physiological Reviews, 2002P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40–50% identical in amino acid sequence. Each subunit has two transmembrane domains, separated by an extracellular domain (∼280 amino acids). Channels form as multimers of several subunits.
openaire +3 more sources
Molecular Structure of P2X Receptors
Current Topics in Medicinal Chemistry, 2004P2X receptors are ligand-gated ion channels that transduce many of the physiological effects of extracellular ATP. There has been a dramatic increase in awareness of these receptors over the past 5 or so years, in great part due to their molecular cloning and characterization.
Terrance M, Egan +2 more
openaire +2 more sources
Molecular properties of P2X receptors
Pflügers Archiv - European Journal of Physiology, 2006P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven genes (P2X(1-7)) have been cloned and the channels form as either homo or heterotrimeric channels giving rise to a wide range ...
Roberts, Jonathan A. +6 more
openaire +3 more sources
P2X receptors in peripheral neurons
Progress in Neurobiology, 2001P2X receptors are a family of ligand-gated ion channels, activated by extracellular ATP. The seven subunits cloned (P2X1-7) can assemble to form homomeric and heteromeric receptors. Peripheral neurons of neural crest origin (e.g. those in dorsal root, trigeminal, sympathetic and enteric ganglia) and placodal origin (e.g.
P M, Dunn, Y, Zhong, G, Burnstock
openaire +2 more sources
P2X receptors and synaptic plasticity
Neuroscience, 2009Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of ATP is mediated through metabotropic P2Y and ionotropic P2X receptors abundantly expressed in neural cells.
Pankratov, Y. +3 more
openaire +2 more sources
2015
P2X receptors are ubiquitously expressed in all epithelial tissues, but their functional roles are less well studied. Here we review the current state of knowledge by focusing on functional effects of P2X receptor in secretory and in absorptive tissues. In glandular tissue like the parotid gland, basolateral P2X receptors stimulate ion secretion via an
openaire +2 more sources
P2X receptors are ubiquitously expressed in all epithelial tissues, but their functional roles are less well studied. Here we review the current state of knowledge by focusing on functional effects of P2X receptor in secretory and in absorptive tissues. In glandular tissue like the parotid gland, basolateral P2X receptors stimulate ion secretion via an
openaire +2 more sources
Science's STKE, 2007
Fountain et al . report the identification and characterization of an ATP receptor in Dictyostelium discoideum that is homologous to vertebrate P2X receptors. When heterologously expressed in the human embryonic kidney (HEK) cell line, the protein was localized to the plasma membrane, was ...
openaire +1 more source
Fountain et al . report the identification and characterization of an ATP receptor in Dictyostelium discoideum that is homologous to vertebrate P2X receptors. When heterologously expressed in the human embryonic kidney (HEK) cell line, the protein was localized to the plasma membrane, was ...
openaire +1 more source
Homology Modeling of P2X Receptors
2019Since the X-ray structure of the zebra fish P2X4 receptor in the closed state was published in 2009 homology modeling has been used to generate structural models for P2X receptors. In this chapter, we outline how to use the MODELLER software to generate such structural models for P2X receptors whose structures have not been solved yet.
Anastasios, Stavrou +2 more
openaire +2 more sources
2013
P2X receptors are ATP-gated channels and form the third major family of ligand-gated channels. Unlike other neurotransmitter-gated channels, P2X receptors have a widespread distribution outside the brain and are involved in many physiological functions. A main function associated to P2X receptors is chronic pain.
François Rassendren, Lauriane Ulmann
openaire +1 more source
P2X receptors are ATP-gated channels and form the third major family of ligand-gated channels. Unlike other neurotransmitter-gated channels, P2X receptors have a widespread distribution outside the brain and are involved in many physiological functions. A main function associated to P2X receptors is chronic pain.
François Rassendren, Lauriane Ulmann
openaire +1 more source