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Structure, Pharmacology and Roles in Physiology of the P2Y12 Receptor
2017P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. The platelet ADP-receptor which has been denominated P2Y12 receptor is an important target in pharmacotherapy. The receptor couples to Gαi2 mediating an inhibition of cyclic AMP accumulation and additional downstream events including the activation of ...
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Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia
Microglia are the resident brain macrophage cells that are involved in constant surveillance of brain microenvironment. In Alzheimer's disease, microglia get over activated upon the accumulation of Tau and amyloid-β species in the extracellular space, ultimately leading to neurodegeneration.Hariharakrishnan Chidambaram +2 more
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Platelet P2Y12 Receptor Inhibition
American Journal Cardiovascular Drugs, 2010David Vivas, Dominick J. Angiolillo
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Ticagrelor: The First Reversibly Binding Oral P2Y12 Receptor Antagonist
Cardiovascular Therapeutics, 2009Steen Husted, J J J Van Giezen
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Extracellular ADP augments microglial inflammasome and NF‐κB activation via the P2Y12 receptor
European Journal of Immunology, 2020Kengo Moriyama +2 more
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Platelets Express Activated P2Y 12 Receptor in Patients With Diabetes Mellitus
Circulation, 2017Lianqiang Che, Si Zhang, Hongmei Yan
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P2Y 12 Receptor Modulates Sepsis-Induced Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016Elisabetta Liverani +2 more
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