Results 1 to 10 of about 21,827 (153)

Macrophage P2Y12 regulates iron transport and its inhibition protects against atherosclerosis

Journal of Advanced Research
Introduction: Iron retention is commonly observed in atherosclerotic plaques and is believed to be detrimental to atherosclerosis. Platelet P2Y12 is a target of antiplatelet therapy in preventing thrombotic complications of atherosclerosis.
Zhiqing He
exaly   +3 more sources

Thrombus remodelling by reversible and irreversible P2Y12 inhibitors

Platelets, 2023
Pharmacological inhibition of the platelet ADP-receptor P2Y12 is a cornerstone in the prevention of atherothrombotic events in adult patients with acute coronary syndrome (ACS). Thienopyridines such as clopidogrel and prasugrel exert their antithrombotic
Kjersti Tunströmer, Lars Faxälv, Pia Larsson, Tomas L. Lindahl, Niklas Boknäs   +4 more
doaj   +1 more source

Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease

Platelets, 2023
Clopidogrel combined with aspirin is widely used in coronary artery disease (CAD) patients, while some patients exhibit high platelet activity when receiving the combined treatment. Current environmental and genetic factors could only explain part of the
Xiaolei Hu, Mupeng Li, He Li, Peiyuan Song, Yanjiao Zhang, Gan Zhou, Jie Tang, Liming Peng, Qilin Ma, Xiaoping Chen   +9 more
doaj   +1 more source

Abatement of potent P2Y12 antagonist-based dual antiplatelet therapy after coronary intervention: A network meta-analysis of randomized controlled trials

Frontiers in Cardiovascular Medicine, 2023
IntroductionDual antiplatelet therapy (DAPT) including prasugrel or ticagrelor is recommended in patients with acute coronary syndromes (ACS) treated with coronary intervention (PCI).
Oumaima El Alaoui El Abdallaoui, Dániel Tornyos, Réka Lukács, András Komócsi   +3 more
doaj   +1 more source

Comparative Safety and Efficacy of Eight Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

Frontiers in Cardiovascular Medicine, 2022
BackgroundAntithrombotic therapy for patients with atrial fibrillation undergoing percutaneous coronary intervention is facing major treatment problems in clinical practice.MethodsWe firstly conducted a Bayesian network meta-analysis to study the safety ...
Bo Liang, Yong-Chun Zhu, Ning Gu
doaj   +1 more source

The Role and Molecular Mechanism of P2Y12 Receptors in the Pathogenesis of Atherosclerotic Cardiovascular Diseases

Applied Sciences, 2021
The P2Y receptor family is a class of G protein-coupled receptors activated primarily by adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP) and uridine diphosphate (UDP).
Lu Wang, Jinxuan Wang, Jianxiong Xu, Weixi Qin, Yuming Wang, Shisui Luo, Guixue Wang   +6 more
doaj   +1 more source

P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

Chinese Medicine, 2021
Background The P2Y12 receptor is a kind of purinoceptor that is engaged in platelet aggregation, and P2Y12 inhibitors have been used in clinical antithrombotic therapy. The P2Y12 receptor in microglia induces interleukin-1β (IL-1β) expression, which is a
Yanzhen Li, Hong Zhang, Jingwen Yang, Muouyang Zhan, Xuefei Hu, Yongmin Liu, Lingling Yu, Xiaochen Yan, Shangdong Liang, Ruyue Zhang, Ying Lu, Beining Li, Cunzhi Liu, Man Li   +13 more
doaj   +1 more source

Arrestin-3 differentially regulates platelet GPCR subsets

Platelets, 2020
The principal demonstrated role of the nonvisual arrestins in vivo is to limit G protein-coupled receptor (GPCR) signaling. Nonetheless, a direct demonstration of this fundamental ability in platelets remains lacking, despite the prominent role played by
James L. Hutchinson, Xiaojuan Zhao, Rob Hill, Stuart J. Mundell   +3 more
doaj   +1 more source

Increased expression of the P2Y12 receptor is involved in the failure of autogenous arteriovenous fistula caused by stenosis

Renal Failure, 2023
Objective This study investigated the role of the P2Y12 receptor in autogenous arteriovenous fistula (AVF) failure resulting from stenosis.Methods Stenotic venous tissues and blood samples were obtained from patients with end-stage renal disease (ESRD ...
Lei Liu, Jianya Gao, Yuewu Tang, Guangfeng Guo, Hua Gan   +4 more
doaj   +1 more source

Natural P2Y12 inhibitors as antiplatelet leads: A multi-tool in silico study [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Uncontrolled platelet aggregation underlies thrombotic disorders and remains a major contributor to cardiovascular mortality. The platelet-specific P2Y₁₂ receptor is a validated target for antithrombotic therapy.
Abdulrahim A. Alzain, Walaa Ibraheem, Fatima A. Elbadwi, Hagar M. Mohamed, Khaled M. Elamin, Wadah Osman, Asmaa E. Sherif, Tariq M. Ajarba, Ahmed Ashour, Reham M. Samra, Gamal A. Mohamed, Sabrin R.M. Ibrahim   +11 more
doaj   +1 more source