Results 21 to 30 of about 27,659 (185)

Challenge in Predicting Persistence to P2Y12 Inhibitors: A Perspective From the ARTEMIS Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Premature discontinuation of P2Y12 inhibitor therapy has been associated with adverse cardiac events, which might be preventable by improving medication persistence. Current risk models have limited ability to predict patients at risk of P2Y12
Jennifer A. Rymer, Zachary K. Wegermann, Lisa A. Kaltenbach, Laura E. Webb, Eric D. Peterson, Tracy Y. Wang   +5 more
doaj   +1 more source

Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients

Vascular Health and Risk Management, 2023
Rakhmad Hidayat,1– 3 Al Rasyid,2,3 Salim Harris,2,3 Alida Harahap,2 Herqutanto,2 Melva Louisa,2 Erlin Listiyaningsih,4 Aldy Safruddin Rambe,5 Tonny Loho6 1Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia;
Hidayat R, Rasyid A, Harris S, Harahap A, Herqutanto, Louisa M, Listiyaningsih E, Rambe AS, Loho T   +8 more
doaj  

Anti-platelet therapy: ADP receptor antagonists. [PDF]

, 2011
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD, Stan Heptinstall, Yanushi Dullewe Wijeyeratne   +3 more
core   +1 more source

P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events [PDF]

, 2023
BACKGROUND Aspirin is the only antiplatelet agent with a Class I recommendation for long-term prevention of cardiovascular events in patients with coronary artery disease (CAD).
Anna Franzone, Qiang Zhao, Pocock, Stuart, Mauro Chiarito, Stuart Pocock, Seljeflot, Ingebjørg, Heribert Schunkert, Zhao, Qiang, Harald Arnesen, Pirondini, Leah, Hyo-Soo Kim, Roxana Mehran, Leah Pirondini, Yunpeng Zhu, Woodward, Mark, Philippe Gabriel Steg, Deepak L. Bhatt, Schunkert, Heribert, Paolo Calabrò, Kim, Hyo-Soo, Stephan Windecker, Kyung Woo Park, Adnan Kastrati, Gragnano, Felice, Pettersen, Alf-Åge R, Alf-Åge R. Pettersen, Kastrati, Adnan, Davide Cao, Mark Woodward, Steg, Philippe Gabriel, Jeehoon Kang, Marco Valgimigli, Arnesen, Harald, Cao, Davide, Calabro', Paolo, Eugene P. McFadden, Chiarito, Mauro, Kang, Jeehoon, Calabrò, Paolo, Ingebjørg Seljeflot, McFadden, Eugene P, Windecker, Stephan, Bhatt, Deepak L, Park, Kyung Woo, Moritz von Scheidt, Zhu, Yunpeng, Franzone, Anna, von Scheidt, Moritz, Felice Gragnano, Mehran, Roxana, Valgimigli, Marco   +50 more
core   +1 more source

Antinociceptive Effect of Magnolol in a Neuropathic Pain Model of Mouse

Journal of Pain Research, 2021
Xiao Zhang,1,* Juntao Wang,1,* Aihua Sui,2 Nannan Zhang,1 Qiulan Lv,2 Zhenfang Liu3 1Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China; 2Medical Research Center, The ...
Zhang X, Wang J, Sui A, Zhang N, Lv Q, Liu Z   +5 more
doaj  

Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis

Haematologica, 2009
Two sisters with inherited, severe platelet dysfunction associated with P2Y12 deficiency displayed a single base pair deletion in their P2Y12 genes (378delC), resulting in a frame-shift and premature truncation of the protein. GL, the son of one of them,
Gessica Fontana, Jerry Ware, Marco Cattaneo   +2 more
doaj   +1 more source

Genotype-Guided Use of P2Y12 Inhibitors: A Review of Current State of the Art

Frontiers in Cardiovascular Medicine, 2022
The pharmacodynamics of the purinergic receptor type Y, subtype 12 (P2Y12) inhibitors has evolved. Our understanding of the metabolism of P2Y12 inhibitors has revealed polymorphisms that impact drug metabolism and antiplatelet efficacy, leading to ...
Abdullah Al-abcha, Yasser Radwan, Danielle Blais, Ernest L. Mazzaferri, Konstantinos Dean Boudoulas, Essa M. Essa, Richard J. Gumina   +6 more
doaj   +1 more source

Perioperative P2Y12 Platelet Function Testing

, 2021
Purpose: The purpose of this article is to review the need for platelet function P2Y12 testing in the perioperative vascular setting to identify the possibility of clopidogrel resistance (CR), and thus allow for alternative antiplatelet prescribing ...
Roberts, David
core   +1 more source

Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets

Platelets, 2022
Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively.
Carol Dangelmaier, Satya P Kunapuli
doaj   +1 more source

The histograms for distribution of P2Y12 reaction unit (PRU) and percent inhibition measured by VerifyNow P2Y12 assay.

, 2023
The histograms for distribution of P2Y12 reaction unit (PRU) and percent inhibition measured by VerifyNow P2Y12 assay.
Seung Bin Kim (16425925), Noah Hong (16437599), Hee-Jin Yang (15234199), Young-Je Son (16437602)   +3 more
core   +1 more source