Results 11 to 20 of about 25,852 (233)
Platelet P2Y12 is involved in murine pulmonary metastasis. [PDF]
PLoS ONE, 2013 The involvement of platelets in tumor progression is well recognized. The depletion of circulating platelets or pharmacologic inhibitors of platelet activation decreases the metastatic potential of circulating tumor cells in metastasis mouse models.
Yanhua Wang +7 more
doaj +6 more sources
D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function [PDF]
International Journal of Molecular Sciences, 2022 Platelets are anucleate cells that mediate hemostasis. This occurs via a primary signal that is reinforced by secreted products such as ADP that bind purinergic receptors (P2Y1 and P2Y12) on the platelet surface. We recently identified a human subject, whom we termed platelet defect subject 25 (PDS25) with a platelet functional disorder associated with
Dangelmaier, Carol +4 more
core +5 more sources
Hämostaseologie, 2009 SummaryThe P2Y12 receptor has proven to be a key target in the prevention of complications associated with atherosclerotic vascular disease especially in the context of acute coronary syndrome and percutaneous coronary intervention in addition to aspirin.
J-P, Collet, G, Montalescot
openaire +3 more sources
Microglial P2Y12 deficiency/inhibition protects against brain ischemia. [PDF]
PLoS ONE, 2013 Microglia are among the first immune cells to respond to ischemic insults. Triggering of this inflammatory response may involve the microglial purinergic GPCR, P2Y12, activation via extracellular release of nucleotides from injured cells.
Corey M Webster +6 more
doaj +4 more sources
Journal of Thrombosis and Haemostasis, 2009 A number of new antiplatelet agents currently in development are anticipated to improve clinical outcomes and safety benefits in patients with acute coronary syndrome (ACS). This article reviews the pharmacology and clinical development of three of these agents: prasugrel, cangrelor, and ticagrelor.
M. Cattaneo
openaire +5 more sources
The influence of variation in the P2Y12 receptor gene on in vitro platelet inhibition with the direct P2Y12 antagonist cangrelor [PDF]
Thrombosis and Haemostasis, 2010 SummaryNovel P2Y12 inhibitors are in development to overcome the occurrence of atherothrombotic events associated with poor responsiveness to the widely used P2Y12 inhibitor clopidogrel. Cangrelor is an intravenously administered P2Y12 inhibitor that does not need metabolic conversion to an active metabolite for its antiplatelet action, and as a ...
Bouman, HJ +8 more
openaire +3 more sources
Association of polymorphisms of platelet receptors GPIa (807C>T), GPVI (13254T>C), and P2Y12 (34C>T and H1/H2 haplotype) with increased risk of periprocedural bleeding in patients undergoing coronary angiography/percutaneous coronary intervention [PDF]
Advances in Interventional Cardiology, 2017 Introduction: Periprocedural bleeding related to coronary angiography (CAG) or percutaneous coronary intervention (PCI) is associated with worse prognosis. Determining genetic variations associated with increased bleeding risk may help to identify high-
Magdalena Sionova +5 more
doaj +2 more sources
Effect of P2Y12 inhibitors on inflammation and immunity [PDF]
Thrombosis and Haemostasis, 2015 SummaryPlatelet P2Y12 inhibitors form a major part of the treatment strategy for patients with acute coronary syndromes (ACS) due to the importance of the platelet P2Y12 receptor in mediating the pathophysiology of arterial thrombosis. It has been increasingly recognised that platelets also have a critical role in inflammation and immune responses ...
Mark R, Thomas, Robert F, Storey
openaire +3 more sources
Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis [PDF]
Haematologica, 2009 Two sisters with inherited, severe platelet dysfunction associated with P2Y12 deficiency displayed a single base pair deletion in their P2Y12 genes (378delC), resulting in a frame-shift and premature truncation of the protein. GL, the son of one of them,
Gessica Fontana +2 more
doaj +3 more sources
P2Y12 platelet inhibition in clinical practice [PDF]
Journal of Thrombosis and Thrombolysis, 2011 Platelet adhesion, activation and aggregation play a pivotal role in atherothrombosis. Intracoronary atherothrombosis is the most common cause of the development of acute coronary syndrome (ACS), and plays a central role in complications occurring around percutaneous coronary intervention (PCI) including recurrent ACS, procedure-related myocardial ...
Damman, Peter +4 more
openaire +5 more sources