Results 11 to 20 of about 21,936 (207)

Platelet P2Y12 is involved in murine pulmonary metastasis. [PDF]

PLoS ONE, 2013
The involvement of platelets in tumor progression is well recognized. The depletion of circulating platelets or pharmacologic inhibitors of platelet activation decreases the metastatic potential of circulating tumor cells in metastasis mouse models.
Yanhua Wang, Yueping Sun, Ding Li, Lin Zhang, Kemin Wang, Yong Zuo, T Kent Gartner, Junling Liu   +7 more
doaj   +1 more source

Increased expression of the P2Y12 receptor is involved in the failure of autogenous arteriovenous fistula caused by stenosis

Renal Failure, 2023
Objective This study investigated the role of the P2Y12 receptor in autogenous arteriovenous fistula (AVF) failure resulting from stenosis.Methods Stenotic venous tissues and blood samples were obtained from patients with end-stage renal disease (ESRD ...
Lei Liu, Jianya Gao, Yuewu Tang, Guangfeng Guo, Hua Gan   +4 more
doaj   +1 more source

Natural P2Y12 inhibitors as antiplatelet leads: A multi-tool in silico study [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Uncontrolled platelet aggregation underlies thrombotic disorders and remains a major contributor to cardiovascular mortality. The platelet-specific P2Y₁₂ receptor is a validated target for antithrombotic therapy.
Abdulrahim A. Alzain, Walaa Ibraheem, Fatima A. Elbadwi, Hagar M. Mohamed, Khaled M. Elamin, Wadah Osman, Asmaa E. Sherif, Tariq M. Ajarba, Ahmed Ashour, Reham M. Samra, Gamal A. Mohamed, Sabrin R.M. Ibrahim   +11 more
doaj   +1 more source

Microglial P2Y12 deficiency/inhibition protects against brain ischemia. [PDF]

PLoS ONE, 2013
Microglia are among the first immune cells to respond to ischemic insults. Triggering of this inflammatory response may involve the microglial purinergic GPCR, P2Y12, activation via extracellular release of nucleotides from injured cells.
Corey M Webster, Masaaki Hokari, April McManus, Xian Nan Tang, Hualong Ma, Rachid Kacimi, Midori A Yenari   +6 more
doaj   +1 more source

Challenge in Predicting Persistence to P2Y12 Inhibitors: A Perspective From the ARTEMIS Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Premature discontinuation of P2Y12 inhibitor therapy has been associated with adverse cardiac events, which might be preventable by improving medication persistence. Current risk models have limited ability to predict patients at risk of P2Y12
Jennifer A. Rymer, Zachary K. Wegermann, Lisa A. Kaltenbach, Laura E. Webb, Eric D. Peterson, Tracy Y. Wang   +5 more
doaj   +1 more source

P2Y12 receptor in platelet activation

Platelets, 2011
ADP plays an important role in hemostasis and thrombosis. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and thrombus formation. Thus, the P2Y12 receptor has been an effective target for antithrombotic drugs.
Soochong, Kim, Satya P, Kunapuli
openaire   +2 more sources

Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients

Vascular Health and Risk Management, 2023
Rakhmad Hidayat,1– 3 Al Rasyid,2,3 Salim Harris,2,3 Alida Harahap,2 Herqutanto,2 Melva Louisa,2 Erlin Listiyaningsih,4 Aldy Safruddin Rambe,5 Tonny Loho6 1Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia;
Hidayat R, Rasyid A, Harris S, Harahap A, Herqutanto, Louisa M, Listiyaningsih E, Rambe AS, Loho T   +8 more
doaj  

Antinociceptive Effect of Magnolol in a Neuropathic Pain Model of Mouse

Journal of Pain Research, 2021
Xiao Zhang,1,* Juntao Wang,1,* Aihua Sui,2 Nannan Zhang,1 Qiulan Lv,2 Zhenfang Liu3 1Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China; 2Medical Research Center, The ...
Zhang X, Wang J, Sui A, Zhang N, Lv Q, Liu Z   +5 more
doaj  

Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis

Haematologica, 2009
Two sisters with inherited, severe platelet dysfunction associated with P2Y12 deficiency displayed a single base pair deletion in their P2Y12 genes (378delC), resulting in a frame-shift and premature truncation of the protein. GL, the son of one of them,
Gessica Fontana, Jerry Ware, Marco Cattaneo   +2 more
doaj   +1 more source

Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets

Platelets, 2022
Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively.
Carol Dangelmaier, Satya P Kunapuli
doaj   +1 more source