Results 31 to 40 of about 27,659 (185)

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395

Platelets, 2018
The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation.
Annachiara Mitrugno, Rachel A. Rigg, Nicole B. Laschober, Anh T. P. Ngo, Jiaqing Pang, Craig D. Williams, Joseph E. Aslan, Owen J. T. McCarty   +7 more
doaj   +1 more source

Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes.

PLoS ONE, 2013
Leukotriene E4 (LTE4), the most stable of the cysteinyl leukotrienes (cysLTs), binds poorly to classical type 1 and 2 cysLT receptors although in asthmatic individuals it may potently induce bronchial constriction, airway hyperresponsiveness and ...
Holly R Foster, Elisabeth Fuerst, Tak H Lee, Davis J Cousins, Grzegorz Woszczek   +4 more
doaj   +1 more source

Platelet P2Y12 Inhibitor in the Treatment and Prevention of Migraine: A Systematic Review and Meta-Analysis

Behavioural Neurology, 2022
There have been speculation and research linking migraine with abnormalities of platelet aggregation and activation. The role of the P2Y12 platelet inhibitor in the treatment of migraine has not been established.
Fengzhi Wang, Yumeng Cao, Yanjie Liu, Zhanxiu Ren, Fuyong Li   +4 more
doaj   +1 more source

Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Patients Treated With P2Y12 Inhibitors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The ADAPTABLE (Aspirin Dosing: A Patient‐Centric Trial Assessing Benefits and Long‐Term Effectiveness) was a large, pragmatic, randomized controlled trial that found no difference between high‐ versus low‐dose aspirin for secondary prevention ...
Saket Girotra, Amanda Stebbins, Lisa Wruck, Guillaume Marquis‐Gravel, Kamal Gupta, Peter Farrehi, Catherine P. Benziger, Mark B. Effron, Jeffrey Whittle, Daniel Muñoz, Sunil Kripalani, R. David Anderson, Sandeep K. Jain, Tamar S. Polonsky, Faraz S. Ahmad, Matthew T. Roe, Russell L. Rothman, Robert A. Harrington, Adrian F. Hernandez, W. Schuyler Jones   +19 more
doaj   +1 more source

Differential endosomal sorting of a novel P2Y12 purinoreceptor mutant

, 2013
P2Y12 receptor internalization and recycling play an essential role in ADP-induced platelet activation. Recently, we identified a patient with a mild bleeding disorder carrying a heterozygous mutation of P2Y12 (P341A) whose P2Y12 receptor recycling was ...
Mundell, Stuart J, Cunningham, Margaret R, Cooke, Alexandra E, Nisar, Shaista P, Emery, Elizabeth D   +4 more
core   +4 more sources

P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells

Scientific Reports, 2021
P2Y12 blockade improves patient outcomes after myocardial infarction. As well as antithrombotic effects, anti-inflammatory effects may contribute to this beneficial clinical outcome.
Patrick M. Siegel, Laura Sander, Alba Fricke, Johannes Stamm, Xiaowei Wang, Prerna Sharma, Nicole Bassler, Ya-Lan Ying, Christoph B. Olivier, Steffen U. Eisenhardt, Christoph Bode, Ingo Ahrens, Philipp Diehl, Karlheinz Peter   +13 more
doaj   +1 more source

The cellular distribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-induced status epilepticus and literature review

Brain Circulation
BACKGROUND: When a seizure occurs, the distribution of purine receptors in different cell types at various time points remains poorly understood. Our literature review revealed that P2X7, P2Y6, and P2Y12 are expressed in different cells during epilepsy ...
Yue Li, Fengru Tang, Yumin Luo
doaj   +1 more source

P2Y12 Inhibitor Monotherapy: Considerations for Acute and Long-Term Secondary Prevention Post-PCI

Reviews in Cardiovascular Medicine, 2022
Following percutaneous coronary intervention (PCI), an initial course of dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor (P2Y12-i) is recommended to minimize the risk of thrombotic complications.
Antonio Greco, Maria Sara Mauro, Davide Capodanno, Dominick J. Angiolillo   +3 more
doaj   +1 more source

Efficacy and Safety of Dual Antiplatelet Therapy in Patients Undergoing Coronary Stent Implantation: A Systematic Review and Network Meta-Analysis

Journal of Interventional Cardiology, 2021
Introduction. This network meta-analysis aimed to evaluate the efficacy and safety of different dual antiplatelet therapies (DAPTs) after percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods.
Yi Xu, Yimin Shen, Delong Chen, Pengfei Zhao, Jun Jiang   +4 more
doaj   +1 more source

Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis

Cell & Bioscience, 2023
Background Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer’s disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity.
Subashchandrabose Chinnathambi, Rashmi Das   +1 more
doaj   +1 more source