Results 51 to 60 of about 25,852 (233)

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

P2Y12 inhibitors for acute coronary syndromes: current perspectives [PDF]

, 2015
James J Nawarskas,1 Cheyenne Newsome,2 Joe R Anderson,1 Bina Ahmed3 1Department of Pharmacy Practice and Pharmacy Administration, The University of New Mexico College of Pharmacy, 2Department of Pharmacy, The University of New Mexico Hospitals ...
Newsome C, Ahmed B, Anderson JR, Nawarskas JJ   +3 more
core  

P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials. [PDF]

, 2021
OBJECTIVE To assess the risks and benefits of P2Y12 inhibitor monotherapy compared with dual antiplatelet therapy (DAPT) and whether these associations are modified by patients' characteristics.
Watanabe, Hirotoshi, Gragnano, Felice, Jüni, Peter, Song, Young Bin, Vranckx, Pascal, Zhao, Qiang, Hong, Sung-Jin, Dangas, George D, Gibson, Charles M, Gwon, Hyeon-Cheol, Hahn, Joo-Yong, Ando, Kenji, Angiolillo, Dominick J, McFadden, Eùgene P, Kim, Byeong-Keuk, Heg, Dik, Windecker, Stephan, Branca, Mattia, Zhu, Yunpeng, Baber, Usman, Franzone, Anna, Jang, Yangsoo, Kimura, Takeshi, Mehta, Shamir, Valgimigli, Marco, Serruys, Patrick W, Mehran, Roxana   +26 more
core   +1 more source

Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model

Platelets, 2019
Platelet hyperaggregation and hypercoagulation are associated with increase of thrombogenic risk, especially in patients with type 2 diabetes (T2D).
Ming Zhou, Meng Gao, Yanwei Luo, Rong Gui, Hongwen Ji   +4 more
doaj   +1 more source

Multifaceted Intervention to Improve P2Y12 Inhibitor Adherence After Percutaneous Coronary Intervention: A Stepped Wedge Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background P2Y12 inhibitor medications are critical following percutaneous coronary intervention (PCI); however, adherence remains suboptimal. Our objective was to assess the effectiveness of a multifaceted intervention to improve P2Y12 inhibitor ...
P. Michael Ho, Colin I. O’Donnell, Marina McCreight, Anthony A. Bavry, Hayden B. Bosworth, Saket Girotra, P. Michael Grossman, Christian Helfrich, Faisal Latif, David Lu, Michael Matheny, Kreton Mavromatis, Jose Ortiz, Amitabh Parashar, Devona M. Ratliff, Gary K. Grunwald, Michael Gillette, Hani Jneid   +17 more
doaj   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Platelet membrane receptor P2Y12 H1/H2 polymorphisms is highly associated with cerebral infarction: a case-control study [PDF]

, 2018
Shu-Jun Lu, Xiao-Sheng Zhou, Qi Zheng, Hong-Liang Chen, Yan-Lei Geng Department of Neurology, Binzhou Medical University Hospital, Binzhou, People’s Republic of China Objectives: This study aimed to determine the relationship between the ...
Lu SJ, Zheng Q, Zhou XS, Chen HL, Geng YL   +4 more
core  

Early P2Y12 Inhibitors Escalation in Primary PCI Patients: Insights from the RENOVAMI Registry [PDF]

, 2018
Background Early escalation from clopidogrel to new generation P2Y12 inhibitors is common practice in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI).
Emanuele Meliga, Luigina Guasti, Alessandro Lupi, Bona, Roberta Della, Capodanno, Davide, Alon Schaffer, Roberta Bona, Porto I, Meliga, Emanuele, Dimitrios Alexopoulos, Davide Capodanno, Marco Valgimigli, Lupi A, Bongo, Angelo S., Lupi, Alessandro, Guasti L, Bongo AS, Della Bona R, Gaudio G, Guasti, Luigina, Capodanno D, Alexopoulos D, Alexopoulos, Dimitrios, Giovanni Gaudio, Meliga E, Bongo, Angelo S, Schaffer A, Italo Porto, Valgimigli M, Schaffer, Alon, Angelo Bongo, Porto, Italo, Gaudio, Giovanni, Valgimigli, Marco   +33 more
core   +1 more source

De-Escalation Dual Antiplatelet Therapy Prevail over Potent P2Y12 Inhibitor Monotherapy in Patients with Acute Coronary Syndrome Undergone Percutaneous Coronary Intervention: A Network Meta-Analysis

Reviews in Cardiovascular Medicine, 2022
Background: Dual antiplatelet therapy (DAPT) with potent P2Y12 inhibitor is the cornerstone of acute coronary syndrome (ACS) management. Balancing the effects of different strategies of antiplatelet therapy including DAPT de-escalation, potent P2Y12 ...
Jing-Wen Ding, Yang Chen, Zuo-Zhong Yu, Yuan-Bin Zhao, Kun-Peng Fan, Xiong-Da Yao, Long-Long Hu, Yan-Hui Liao, Tian-Hua Deng, Yi Xia, Han-Hui Liao, Ren-Qiang Yang   +11 more
doaj   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source