Results 1 to 10 of about 6,158 (119)

ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Tozzi M, Berggreen EB, Zhang R, Gudiksen A, Li W, Matz MB, Pilegaard H, Hansen JB, Novak I.   +8 more
europepmc   +2 more sources

ATP-related purinergic signaling via P2Y12 contributes to airway epithelial barrier integrity [PDF]

BMC Molecular and Cell Biology
Background The airway epithelial barrier, which defends against external pathogens, is compromised in bronchial asthma. This study investigated the roles of adenosine triphosphate (ATP) and specific purinergic receptors in airway epithelial barrier ...
Kota Tsuya, Shuichiro Maruoka, Shinichi Okamoto, Sotaro Shikano, Mari Ujike, Shiho Yamada, Yusuke Kurosawa, Kenji Mizumura, Yutaka Kozu, Yasuhiro Gon   +9 more
doaj   +2 more sources

Current status and future perspectives of platelet function-guided precision antiplatelet therapy for patients with cerebral infarction. [PDF]

Neuroprotection
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Zhu G, Chen X, Huang X, Tan Q, Cao Q, Yang Y, Lin Y, Yang J.   +7 more
europepmc   +2 more sources

Bisphenols-enhanced platelet aggregation via TP, P2Y12, PAR1 and PAR4 receptors: a thrombotic legacy in a plastic-ubiquitous world [PDF]

Frontiers in Pharmacology
BackgroundCardiovascular diseases remain an urgent global health concern addressed by multiple clinical guidelines. Atherothrombosis is characterised by thrombus formation following disruption of atherosclerotic plaque, leading to major adverse ...
Opata Edward Kwame, Aurora de la Peña-Díaz, Yesenia I. Martínez-Jiménez, Mirthala Flores-García, Emma S. Calderón-Aranda, Irene Lee-Rivera, Rocío Gómez   +6 more
doaj   +2 more sources

Purinergic Receptors in Dendritic Cells [PDF]

Journal of Inflammation Research
Miaomiao Wang,1 Xiaoxiao Zhao,1 Shuai Hou,1 Zhongbo Wu,2 Hai-yan Yin1 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Brain Disease Research Center, Tongren People’s ...
Wang M, Zhao X, Hou S, Wu Z, Yin HY
doaj   +2 more sources

Heart failure-induced reprogramming of salt-evoked neurovascular coupling in the rat hypothalamus. [PDF]

J Physiol
Abstract figure legend In sham rat, hypertonic saline induces activation of the AVP neurons, leading to dendritic AVP release and subsequent V1aR‐mediated PA vasoconstriction resulting in local tissue hypoxia in the SON. In heart failure rat, hypertonic saline similarly induces activation of the AVP neuron leading to dendritic AVP release.
Roy RK, Lira EC, Ongolo MB, Filosa JA, Stern JE.   +4 more
europepmc   +2 more sources

SARS-CoV-2 Spike protein alters microglial purinergic signaling

Frontiers in Immunology, 2023
Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of ...
Vinícius Santos Alves, Stephanie Alexia Cristina Silva Santos, Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Renata Rodrigues dos Reis, Mariana L. Calazans, Gabriel Gripp Fernandes, Leticia Silva Antônio, Emanuelle V. de Lima, Eleonora Kurtenbach, Jerson Lima Silva, Fabricia Lima Fontes-Dantas, Fabricia Lima Fontes-Dantas, Giselle Fazzioni Passos, Cláudia Pinto Figueiredo, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +16 more
doaj   +1 more source

Purinergic signaling: A gatekeeper of blood-brain barrier permeation

Frontiers in Pharmacology, 2023
This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Yuemei Wang, Yuanbing Zhu, Junmeng Wang, Longcong Dong, Shuqing Liu, Sihui Li, Qiaofeng Wu   +6 more
doaj   +1 more source

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders

Brain Sciences, 2023
Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec, Anna Wilkaniec, Marta Matuszewska, Ewelina Pałasz, Magdalena Cieślik, Agata Adamczyk   +5 more
doaj   +1 more source

Identification of a carbohydrate recognition motif of purinergic receptors

eLife, 2023
As a major class of biomolecules, carbohydrates play indispensable roles in various biological processes. However, it remains largely unknown how carbohydrates directly modulate important drug targets, such as G-protein coupled receptors (GPCRs).
Lifen Zhao, Fangyu Wei, Xinheng He, Antao Dai, Dehua Yang, Hualiang Jiang, Liuqing Wen, Xi Cheng   +7 more
doaj   +1 more source