Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 ReceptorSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Chronic abdominal pain is a common symptom of inflammatory bowel diseases (IBDs). Peripheral and central mechanisms contribute to the transition from acute to chronic pain during active disease and clinical remission.
Manon Defaye +8 more
doaj +1 more source
Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery
Molecules, 2012 Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves +4 more
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Purines as potential morphogens during embryonic development [PDF]
, 2012 Components of purinergic signalling are expressed in the early embryo raising the possibility that ATP, ADP and adenosine may contribute to the mechanisms of embryonic development.
Dale, Nicholas +3 more
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Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone [PDF]
, 2002 Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials.
Catsicas, M. +15 more
core +1 more source
Brain CirculationBACKGROUND: When a seizure occurs, the distribution of purine receptors in different cell types at various time points remains poorly understood. Our literature review revealed that P2X7, P2Y6, and P2Y12 are expressed in different cells during epilepsy ...
Yue Li, Fengru Tang, Yumin Luo
doaj +1 more source
Gene‐by‐environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma [PDF]
Clinical & Experimental Allergy, 2011 SummaryBackgroundDistinct receptors likely exist for leukotriene (LT)E4, a potent mediator of airway inflammation. Purinergic receptor P2Y12 is needed for LTE4‐induced airways inflammation, and P2Y12 antagonism attenuates house dust mite‐induced pulmonary eosinophilia in mice.
Bunyavanich, S. +3 more
openaire +4 more sources
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ +18 more
core +1 more source
P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
core +1 more source
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M. +10 more
core +1 more source
Purinergic mechanosensory transduction and visceral pain [PDF]
, 2009 In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock +2 more
core +1 more source