Results 51 to 60 of about 6,211 (154)

Functional interaction between purinergic receptors: effect of ligands for A_2Aand P2Y₁₂receptors on P2Y₁receptor function

FEBS Letters, 2011
A(2A) adenosine receptor (A(2A)R), P2Y(1) receptor (P2Y(1)R) and P2Y(12) receptor (P2Y(12)R) are predominantly expressed on human platelets. The individual role of each of these receptors in platelet aggregation has been actively reported. Previously, hetero-oligomerization between these three receptors has been shown to occur. Here, we show that Ca(2+)
Suzuki, Tokiko, Obara, Yutaro, Moriya, Takahiro, Nakata, Hiroyasu, Nakahata, Norimichi   +4 more
openaire   +2 more sources

A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease [PDF]

Journal of Allergy and Clinical Immunology, 2019
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, recurrent nasal polyposis, and respiratory reactions on ingestion of COX-1 inhibitors. Increased numbers of platelet-leukocyte aggregates are present in the sinus tissue and blood of patients with AERD compared with that of aspirin-tolerant patients, and platelet activation can ...
Tanya M, Laidlaw, Katherine N, Cahill, Juan Carlos, Cardet, Katherine, Murphy, Jing, Cui, Brittney, Dioneda, Parul, Kothari, Benjamin A, Raby, Elliot, Israel, Joshua A, Boyce   +9 more
openaire   +2 more sources

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Glia, Volume 74, Issue 10, October 2026.
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner, Henrike Antony, Cornelia Hoyer, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R. Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann   +13 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

Neurobiology of Disease, 2014
Microglia, the immune cells of the central nervous system, constantly survey the parenchyma in the healthy brain to maintain homeostasis. When a disturbance, such as cell death, results in ATP release in vivo, microglial processes respond by utilizing ...
Stefka Gyoneva, Lauren Shapiro, Carlos Lazo, Ethel Garnier-Amblard, Yoland Smith, Gary W. Miller, Stephen F. Traynelis   +6 more
doaj   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, Volume 13, Issue 38, 9 July 2026.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Comparative bioavailability of a novel fixed‐dose combination of ticagrelor and acetylsalicylic acid

Clinical Pharmacology in Drug Development, Volume 15, Issue 7, July 2026.
Abstract Dual antiplatelet therapy (DAPT) with acetylsalicylic acid (hereafter referred to as ASA) and ticagrelor is the standard of care for secondary prevention for atherothrombotic events, particularly in patients with noncardioembolic cerebrovascular disease or coronary artery disease.
Susana Tera‐Ponce, Perla E. Castañeda‐Tera, Elva J. García‐Real, Francisco Ávila‐García, Kevin F. Rios‐Brito, Laura A. Lugo‐Sánchez, Daniel E. Sandoval‐Colin, Paola M. Medina‐Cárdenas, Jorge González‐Canudas   +8 more
wiley   +1 more source

Immunoaffinity‐Based Protocol to Enrich Nervous System Cell‐, Lung Alveolar Cell‐, and Hepatocyte‐Derived Extracellular Vesicles From Human Plasma

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT By preserving molecular information inherited from the source cell, extracellular vesicles (EVs) can serve as biomarkers for tissue health or disease, paving the way for liquid biopsy applications. The enrichment of tissue‐specific EVs (TS‐EVs) from human biofluids can be challenging due to technical and methodological limitations.
Biancamaria Pierri, Gabriela L. Jackson, Olesia Gololobova, Fang Wang, Erez Eitan, Olga Volpert, Vrinda Kalia, Gissette Reyes‐Soffer, Louise C. Laurent, Kenneth W. Witwer, Andrea A. Baccarelli, Haotian Wu   +11 more
wiley   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source

Hypoxia induced amoeboid microglial cell activation in postnatal rat brain is mediated by ATP receptor P2X4

BMC Neuroscience, 2011
Background Activation of amoeboid microglial cells (AMC) and its related inflammatory response have been linked to the periventricular white matter damage after hypoxia in neonatal brain.
Li Fan, Wang Lei, Li Ji-Wei, Gong Min, He Liang, Feng Rui, Dai Zhen, Li Shu-Qing   +7 more
doaj   +1 more source