Results 61 to 70 of about 6,211 (154)

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y₁₂ purinergic receptors

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008
Cholangiocytes, the epithelial cells lining intrahepatic bile ducts, contain primary cilia, which are mechano- and osmosensory organelles detecting changes in bile flow and osmolality and transducing them into intracellular signals. Here, we asked whether cholangiocyte cilia are chemosensory organelles by testing the expression of P2Y purinergic ...
Banales, J.M. (Jesús M.), Stroope, A. (Angela), LaRusso, N.F. (Nicholas F.), Splinter, P.L. (Patrick L.), Lee, S.O. (Seung-Ok), Masyuk, A.I. (Anatoly I.), Huang, B.Q. (Bing Q.), Masyuk, T.V. (Tatyana V.), Gradilone, S.A. (Sergio A.)   +8 more
openaire   +4 more sources

BLOOD PLATELETS AS ACTIVATORS AND REGULATORS OF INFLAMMATORY AND IMMUNE REACTIONS. PART 1. BASIC CHARACTERISTICS OF PLATELETS AS INFLAMMATORY CELLS

Медицинская иммунология, 2018
Platelets are the smallest blood cells, and yet their total volume and surface area exceed those of all types of leukocytes combined. Platelets are produced by the bone marrow megakaryocytes and megakaryocytes in the lung microvessels.
N. B. Serebryanaya, S. N. Shanin, E. E. Fomicheva, P. P. Yakutseni   +3 more
doaj   +1 more source

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract BACKGROUND Genetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD‐associated ABI3S209F (Abi3S212F in mouse) variant regulates cytoskeletal dynamics, but its in vivo impact on pathology is unknown. METHODS: An Abi3S212F mouse was developed and crossed with
Claire A. Butler, Min Sung Gee, Katie O'Gara, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Yueh‐Hao Lu, Nellie Kwang, Kate I. Tsourmas, Christiana Prekopa, Zechuan Shi, Heidi Yahan Liang, Sherilyn D. Collins, Zachary A. Pashkutz, Jenna A. Sanchez, Kai‐Xuan Shi, Amber D. Walker, Shuling Wang, Maigan L. A. Wong, Karina Genaro, Jonathan Neumann, Angela Gomez‐Arboledas, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Ali Mortazavi, Vivek Swarup, Grant R. MacGregor, Kim N. Green   +29 more
wiley   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

High‐dimensional Spatial Immune Profiling Highlights Microglia‐Like Cells in Human Dorsal Root Ganglia

European Journal of Immunology, Volume 56, Issue 5, May 2026.
High‐dimensional imaging mass cytometry reveals diverse macrophage populations in human dorsal root ganglia (DRG). Microglia‐like cells, characterized by markers such as P2RY12, SLC2A5, and TMEM119, localize near neuronal structures, whereas other myeloid subsets are found in interstitial regions. Spatial analysis reveals distinct localization patterns
Marius Schwabenland, Busranur Oeztuerk, Thomas Blank, Juergen Beck, Bertram Bengsch, Marco Prinz   +5 more
wiley   +1 more source

Evidence that the purinergic receptor P2Y₁₂potentiates platelet shape change by a Rho kinase-dependent mechanism

Platelets, 2005
ADP activates human platelets through two G-protein coupled receptors, P2Y1 and P2Y12, to induce a range of functional responses. Here we have addressed the role and mechanism of P2Y12 in modulating ADP-induced platelet shape change. Although the response depended upon activation of P2Y1, it was potentiated by P2Y12 as the P2Y12-selective antagonists ...
Hardy, AR, Hill, DJ, Poole, AW
openaire   +3 more sources

EXPLORATION OF PURINERGIC SIGNALING PATHWAYS AS A MECHANISM OF PLATELET ACTIVATION IN ANTIPHOSPHOLIPID SYNDROME

Hematology, Transfusion and Cell Therapy
Background: We have previously demonstrated hyperreactivity to ADP, overexpression of the P2Y12 receptor, and reduced intracellular levels of cAMP and cGMP in platelets from Antiphospholipid Syndrome (APS) patients, suggestive of purinergic signaling ...
BC Jacintho-Robison, G Leonardi, BM Mazetto, JD Oliveira, FZ Monica, FA Orsi   +5 more
doaj   +1 more source

Bisphenols-enhanced platelet aggregation via TP, P2Y12, PAR1 and PAR4 receptors: a thrombotic legacy in a plastic-ubiquitous world

Frontiers in Pharmacology
BackgroundCardiovascular diseases remain an urgent global health concern addressed by multiple clinical guidelines. Atherothrombosis is characterised by thrombus formation following disruption of atherosclerotic plaque, leading to major adverse ...
Opata Edward Kwame, Aurora de la Peña-Díaz, Yesenia I. Martínez-Jiménez, Mirthala Flores-García, Emma S. Calderón-Aranda, Irene Lee-Rivera, Rocío Gómez   +6 more
doaj   +1 more source

Blood oxygen regulation via P2Y12R expressed in the carotid body

Respiratory Research
Background Peripheral blood oxygen monitoring via chemoreceptors in the carotid body (CB) is an integral function of the autonomic cardiorespiratory regulation.
András Iring, Mária Baranyi, Bernadett Iring-Varga, Paula Mut-Arbona, Zsuzsanna T. Gál, Dorina Nagy, László Hricisák, János Varga, Zoltán Benyó, Beáta Sperlágh   +9 more
doaj   +1 more source