Results 61 to 70 of about 550,877 (189)

Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation

Frontiers in Neuroscience, 2016
Enterochromaffin cells (EC) synthesize 95% of the body 5-HT and release 5-HT in response to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility, secretion and visceral sensation.
Andromeda Linan Rico, Andromeda Linan Rico, Fernando Ochoa-Cortes, Arthur Beyder, Suren Soghomonyan, Alix Zuleta-Alarcon, Vincenzo Coppola, Fievos Leontiou Christofi   +7 more
doaj   +1 more source

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Glia, Volume 74, Issue 10, October 2026.
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner, Henrike Antony, Cornelia Hoyer, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R. Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann   +13 more
wiley   +1 more source

Blockade of the purinergic P2Y ₁₂ receptor greatly increases the platelet inhibitory actions of nitric oxide [PDF]

Proceedings of the National Academy of Sciences, 2013
Circulating platelets are constantly exposed to nitric oxide (NO) released from the vascular endothelium. This NO acts to reduce platelet reactivity, and in so doing blunts platelet aggregation and thrombus formation. For successful hemostasis, platelet activation and aggregation must occur at sites of vascular injury despite the ...
Nicholas S, Kirkby, Martina H, Lundberg, Melissa V, Chan, Ivana, Vojnovic, Antonia B, Solomon, Michael, Emerson, Jane A, Mitchell, Timothy D, Warner   +7 more
openaire   +2 more sources

ADP receptors P2Y1, P2Y12 and P2Y13 are differentially regulated in a rat model of multiple sclerosis

, 2017
Introduction. Multiple sclerosis (MS) is a chronic disease of central nervous system (CNS), characterized by neuroinflammation, demyelination and neurodegeneration. Despite well-established role of purinergic signaling in MS pathology, the role of ADP as
Božić, Iva, Lavrnja, Irena, Nedeljković, Nadežda, Bjelobaba, Ivana, Savić, Danijela, Adžić, Marija, Jakovljević, Marija, Laketa, Danijela, Peković, Sanja   +8 more
core   +5 more sources

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, Volume 183, Issue 20, Page 5999-6006, October 2026.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Functional interaction between purinergic receptors: effect of ligands for A_2Aand P2Y₁₂receptors on P2Y₁receptor function

FEBS Letters, 2011
A(2A) adenosine receptor (A(2A)R), P2Y(1) receptor (P2Y(1)R) and P2Y(12) receptor (P2Y(12)R) are predominantly expressed on human platelets. The individual role of each of these receptors in platelet aggregation has been actively reported. Previously, hetero-oligomerization between these three receptors has been shown to occur. Here, we show that Ca(2+)
Suzuki, Tokiko, Obara, Yutaro, Moriya, Takahiro, Nakata, Hiroyasu, Nakahata, Norimichi   +4 more
openaire   +2 more sources

A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease [PDF]

Journal of Allergy and Clinical Immunology, 2019
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, recurrent nasal polyposis, and respiratory reactions on ingestion of COX-1 inhibitors. Increased numbers of platelet-leukocyte aggregates are present in the sinus tissue and blood of patients with AERD compared with that of aspirin-tolerant patients, and platelet activation can ...
Tanya M, Laidlaw, Katherine N, Cahill, Juan Carlos, Cardet, Katherine, Murphy, Jing, Cui, Brittney, Dioneda, Parul, Kothari, Benjamin A, Raby, Elliot, Israel, Joshua A, Boyce   +9 more
openaire   +2 more sources

Purinergic-Mediated Calcium Signaling in Quiescent and Activated Hepatic Stellate Cells: Evidence That P2Y1 Receptor Delays Activation

Cells
Hepatic stellate cells (HSC) play a crucial role in the fibrotic response of the liver when they transdifferentiate from quiescent cells (qHSC) to myofibroblast (MFB).
Esperanza Mata-Martínez, Ana Patricia Juárez-Mercado, Adriana González-Gallardo, José David Núñez-Ríos, Mauricio Díaz-Muñoz, Rolando Hernández-Muñoz, Francisco G. Vázquez-Cuevas   +6 more
doaj   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source