Results 71 to 80 of about 550,877 (189)

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

Neurobiology of Disease, 2014
Microglia, the immune cells of the central nervous system, constantly survey the parenchyma in the healthy brain to maintain homeostasis. When a disturbance, such as cell death, results in ATP release in vivo, microglial processes respond by utilizing ...
Stefka Gyoneva, Lauren Shapiro, Carlos Lazo, Ethel Garnier-Amblard, Yoland Smith, Gary W. Miller, Stephen F. Traynelis   +6 more
doaj   +1 more source

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

MedComm, Volume 7, Issue 9, September 2026.
Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao   +9 more
wiley   +1 more source

The developmental journey of therapies targeting purine receptors: from basic science to clinical trials

, 2022
Since the discovery of ATP as an extracellular signalling molecule in 1972, purinergic signalling, mediated by extracellular purines and pyrimidines has been identified in virtually all mammalian tissues and is implicated in regulating fundamental ...
Vlajkovic, Srdjan M., Thorne, Peter R, Suzuki-Kerr, Haruna, Thorne, Peter R., Vlajkovic, Srdjan M, Han, Seunga   +5 more
core   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Objective The neurovascular unit (NVU) is a core structural and functional entity involved in migraine pathogenesis. Acupuncture may exert therapeutic effects by protecting NVU integrity. This narrative review aims to summarize the current evidence on the mechanisms by which acupuncture protects the NVU in migraine.
Yajie Wang, Chao Zhang, Linbo Shen, Yuanyuan Wang, Xiaocheng Wang, Linjing Song, Li Wang, Ningle Zhang, Dayong Ma, Tao Xiong   +9 more
wiley   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, Volume 13, Issue 38, 9 July 2026.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y₁₂ purinergic receptors

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008
Cholangiocytes, the epithelial cells lining intrahepatic bile ducts, contain primary cilia, which are mechano- and osmosensory organelles detecting changes in bile flow and osmolality and transducing them into intracellular signals. Here, we asked whether cholangiocyte cilia are chemosensory organelles by testing the expression of P2Y purinergic ...
Banales, J.M. (Jesús M.), Stroope, A. (Angela), LaRusso, N.F. (Nicholas F.), Splinter, P.L. (Patrick L.), Lee, S.O. (Seung-Ok), Masyuk, A.I. (Anatoly I.), Huang, B.Q. (Bing Q.), Masyuk, T.V. (Tatyana V.), Gradilone, S.A. (Sergio A.)   +8 more
openaire   +4 more sources

Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain

, 2022
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Agata Adamczyk, Anna Wilkaniec, Lidia Babiec   +2 more
core   +1 more source

Hypoxia induced amoeboid microglial cell activation in postnatal rat brain is mediated by ATP receptor P2X4

BMC Neuroscience, 2011
Background Activation of amoeboid microglial cells (AMC) and its related inflammatory response have been linked to the periventricular white matter damage after hypoxia in neonatal brain.
Li Fan, Wang Lei, Li Ji-Wei, Gong Min, He Liang, Feng Rui, Dai Zhen, Li Shu-Qing   +7 more
doaj   +1 more source

Comparative bioavailability of a novel fixed‐dose combination of ticagrelor and acetylsalicylic acid

Clinical Pharmacology in Drug Development, Volume 15, Issue 7, July 2026.
Abstract Dual antiplatelet therapy (DAPT) with acetylsalicylic acid (hereafter referred to as ASA) and ticagrelor is the standard of care for secondary prevention for atherothrombotic events, particularly in patients with noncardioembolic cerebrovascular disease or coronary artery disease.
Susana Tera‐Ponce, Perla E. Castañeda‐Tera, Elva J. García‐Real, Francisco Ávila‐García, Kevin F. Rios‐Brito, Laura A. Lugo‐Sánchez, Daniel E. Sandoval‐Colin, Paola M. Medina‐Cárdenas, Jorge González‐Canudas   +8 more
wiley   +1 more source