Results 81 to 90 of about 550,877 (189)

BLOOD PLATELETS AS ACTIVATORS AND REGULATORS OF INFLAMMATORY AND IMMUNE REACTIONS. PART 1. BASIC CHARACTERISTICS OF PLATELETS AS INFLAMMATORY CELLS

Медицинская иммунология, 2018
Platelets are the smallest blood cells, and yet their total volume and surface area exceed those of all types of leukocytes combined. Platelets are produced by the bone marrow megakaryocytes and megakaryocytes in the lung microvessels.
N. B. Serebryanaya, S. N. Shanin, E. E. Fomicheva, P. P. Yakutseni   +3 more
doaj   +1 more source

Immunoaffinity‐Based Protocol to Enrich Nervous System Cell‐, Lung Alveolar Cell‐, and Hepatocyte‐Derived Extracellular Vesicles From Human Plasma

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT By preserving molecular information inherited from the source cell, extracellular vesicles (EVs) can serve as biomarkers for tissue health or disease, paving the way for liquid biopsy applications. The enrichment of tissue‐specific EVs (TS‐EVs) from human biofluids can be challenging due to technical and methodological limitations.
Biancamaria Pierri, Gabriela L. Jackson, Olesia Gololobova, Fang Wang, Erez Eitan, Olga Volpert, Vrinda Kalia, Gissette Reyes‐Soffer, Louise C. Laurent, Kenneth W. Witwer, Andrea A. Baccarelli, Haotian Wu   +11 more
wiley   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response [PDF]

, 2005
P2X2 receptor subunits of the ATP-gated ion channels are expressed by physiologically identified respiratory neurons in the ventral respiratory column, implicating ATP in the control of respiratory activity.
Spyer, K. Michael, Llaudet, E, Gourine, Alexander V., Spyer, KM, Dale, Nicholas, Llaudet, Enrique, Dale, N, Gourine, AV   +7 more
core   +1 more source

Evidence that the purinergic receptor P2Y₁₂potentiates platelet shape change by a Rho kinase-dependent mechanism

Platelets, 2005
ADP activates human platelets through two G-protein coupled receptors, P2Y1 and P2Y12, to induce a range of functional responses. Here we have addressed the role and mechanism of P2Y12 in modulating ADP-induced platelet shape change. Although the response depended upon activation of P2Y1, it was potentiated by P2Y12 as the P2Y12-selective antagonists ...
Hardy, AR, Hill, DJ, Poole, AW
openaire   +3 more sources

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
Zsilla Gabriella, Csölle Cecília, Csölle, Cecília, Illes Peter, Flóra Gölöncsér, Gabriella Zsilla, Mária Baranyi, Sperlágh, Beáta, Baranyi, Mária, Kittel Ágnes, Peter Illes, Baranyi Mária, Beáta Sperlágh, Vizi E. Szilveszter, E Sylvester Vizi, Zsilla, Gabriella, Papp Edit, Gölöncsér Flóra, Illés, Péter, Gölöncsér, Flóra, E. Sylvester Vizi, Sperlágh Beáta, Illes P, Vizi, E. Szilveszter, Papp, Edit, Edit Papp, Kittel, Ágnes, Agnes Kittel, Cecilia Csölle, Vizi E. Sylvester   +29 more
core   +2 more sources

PET imaging of purinergic receptors

, 2020
Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes
Windhorst, Albert D., Vugts, Danielle J., Janssen, Bieneke   +2 more
core   +1 more source

Purines, Purinergic Receptors, and Cancer [PDF]

, 2012
Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions.
Francesco Di Virgilio, DI VIRGILIO, Francesco   +1 more
core   +1 more source

EXPLORATION OF PURINERGIC SIGNALING PATHWAYS AS A MECHANISM OF PLATELET ACTIVATION IN ANTIPHOSPHOLIPID SYNDROME

Hematology, Transfusion and Cell Therapy
Background: We have previously demonstrated hyperreactivity to ADP, overexpression of the P2Y12 receptor, and reduced intracellular levels of cAMP and cGMP in platelets from Antiphospholipid Syndrome (APS) patients, suggestive of purinergic signaling ...
BC Jacintho-Robison, G Leonardi, BM Mazetto, JD Oliveira, FZ Monica, FA Orsi   +5 more
doaj   +1 more source