Results 31 to 40 of about 550,877 (189)

Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids

Frontiers in Pharmacology, 2018
Plasma levels of the vasoactive substance uridine adenosine tetraphosphate (Up4A) are elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in various arteries isolated from hypertensive animals, suggesting a potential ...
Zhichao Zhou, Zhichao Zhou, Zhichao Zhou, Inge M. Lankhuizen, Inge M. Lankhuizen, Heleen M. van Beusekom, Heleen M. van Beusekom, Caroline Cheng, Caroline Cheng, Caroline Cheng, Dirk J. Duncker, Dirk J. Duncker, Daphne Merkus, Daphne Merkus   +13 more
doaj   +1 more source

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS

Cells, 2020
Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes, Patrizia Rubini, Henning Ulrich, Yafei Zhao, Yong Tang   +4 more
doaj   +1 more source

ATP Induces Interleukin-8, Intracellular Calcium Release, and ERK1/2 Phosphorylation in Bovine Endometrial Cells, Partially through P2Y Receptors

Animals, 2023
The bovine endometrium has an important defensive role in the postpartum period that acts when an inflammatory process associated with tissue damage or infection by bacteria is produced.
Noemí Gutierrez, Stefanie Teuber, Pablo Alarcon, Rafael A. Burgos, María A. Hidalgo   +4 more
doaj   +1 more source

The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets

Pharmacological Research, 2022
Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition; characterized with the degeneration of the nigrostriatal dopaminergic pathway and neuroinflammation. During PD progression, microglia, the resident immune cells in the central nervous system (CNS) display altered activity, but their role in maintaining PD development has ...
Iring, András, Tóth, Adrián, Baranyi, Mária, Otrokocsi, Lilla, Módis, László V, Gölöncsér, Flóra, Varga, Bernadett, Hortobágyi, Tibor, Bereczki, Dániel, Dénes, Ádám, Sperlágh, Beáta   +10 more
openaire   +3 more sources

Association Between Polymorphisms in the Purinergic P2Y12 Receptor Gene and Severity of Both Cancer Pain and Postoperative Pain [PDF]

Pain Medicine, 2017
Despite the widespread use of opioids for the treatment of cancer pain, results from several surveys consistently show that pain is still prevalent in some patients with malignant diseases. The purinergic P2Y12 receptor is a primary site leading to microglial activation and hyperalgesic pain behaviors and is considered a key regulator in the prevention
Masahiko, Sumitani, Daisuke, Nishizawa, Makoto, Nagashima, Kazutaka, Ikeda, Hiroaki, Abe, Ryoji, Kato, Hiroshi, Ueda, Yoshitsugu, Yamada   +7 more
openaire   +2 more sources

Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes.

PLoS ONE, 2013
Leukotriene E4 (LTE4), the most stable of the cysteinyl leukotrienes (cysLTs), binds poorly to classical type 1 and 2 cysLT receptors although in asthmatic individuals it may potently induce bronchial constriction, airway hyperresponsiveness and ...
Holly R Foster, Elisabeth Fuerst, Tak H Lee, Davis J Cousins, Grzegorz Woszczek   +4 more
doaj   +1 more source

Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review

Life, 2020
The purinergic P2Y12 receptor regulates microglial activation, resulting in persistence and aggravation of pain in neuropathic and nociceptive pain models.
Rikuhei Tsuchida, Masahiko Sumitani, Hiroaki Abe, Masae Ando, Kosuke Saita, Kohshi Hattori, Kazuhito Mietani, Reo Inoue, Kanji Uchida   +8 more
doaj   +1 more source

P2Y12 Receptor Antagonist Clopidogrel Attenuates Lung Inflammation Triggered by Silica Particles

Frontiers in Pharmacology, 2020
Silicosis is an occupational lung disease caused by inhalation of silica particles. It is characterized by intense lung inflammation, with progressive and irreversible fibrosis, leading to impaired lung function.
Patricia Teixeira Santana, Tatiana Luna-Gomes, Marcos Vinicius Rangel-Ferreira, Augusto Shuiti Tamura, Carolyne Lalucha Alves Lima Da Graça, Mariana Nascimento Machado, Walter Araujo Zin, Christina Maeda Takiya, Debora Souza Faffe, Robson Coutinho-Silva   +9 more
doaj   +1 more source

Role of Purinergic Receptor Expression and Function for Reduced Responsiveness to Adenosine Diphosphate in Washed Human Platelets. [PDF]

PLoS ONE, 2016
BACKGROUND:Washing of platelets is an important procedure commonly used for experimental studies, e.g. in cardiovascular research. As a known phenomenon, responsiveness to adenosine diphosphate (ADP) is reduced in washed platelets, although underlying ...
Juergen Koessler, Stephanie Hermann, Katja Weber, Angela Koessler, Sabine Kuhn, Markus Boeck, Anna Kobsar   +6 more
doaj   +1 more source

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad   +17 more
core   +2 more sources