Results 31 to 40 of about 6,211 (154)

Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids

Frontiers in Pharmacology, 2018
Plasma levels of the vasoactive substance uridine adenosine tetraphosphate (Up4A) are elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in various arteries isolated from hypertensive animals, suggesting a potential ...
Zhichao Zhou, Zhichao Zhou, Zhichao Zhou, Inge M. Lankhuizen, Inge M. Lankhuizen, Heleen M. van Beusekom, Heleen M. van Beusekom, Caroline Cheng, Caroline Cheng, Caroline Cheng, Dirk J. Duncker, Dirk J. Duncker, Daphne Merkus, Daphne Merkus   +13 more
doaj   +1 more source

Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review

Life, 2020
The purinergic P2Y12 receptor regulates microglial activation, resulting in persistence and aggravation of pain in neuropathic and nociceptive pain models.
Rikuhei Tsuchida, Masahiko Sumitani, Hiroaki Abe, Masae Ando, Kosuke Saita, Kohshi Hattori, Kazuhito Mietani, Reo Inoue, Kanji Uchida   +8 more
doaj   +1 more source

The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets

Pharmacological Research, 2022
Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition; characterized with the degeneration of the nigrostriatal dopaminergic pathway and neuroinflammation. During PD progression, microglia, the resident immune cells in the central nervous system (CNS) display altered activity, but their role in maintaining PD development has ...
Iring, András, Tóth, Adrián, Baranyi, Mária, Otrokocsi, Lilla, Módis, László V, Gölöncsér, Flóra, Varga, Bernadett, Hortobágyi, Tibor, Bereczki, Dániel, Dénes, Ádám, Sperlágh, Beáta   +10 more
openaire   +3 more sources

Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes.

PLoS ONE, 2013
Leukotriene E4 (LTE4), the most stable of the cysteinyl leukotrienes (cysLTs), binds poorly to classical type 1 and 2 cysLT receptors although in asthmatic individuals it may potently induce bronchial constriction, airway hyperresponsiveness and ...
Holly R Foster, Elisabeth Fuerst, Tak H Lee, Davis J Cousins, Grzegorz Woszczek   +4 more
doaj   +1 more source

Association Between Polymorphisms in the Purinergic P2Y12 Receptor Gene and Severity of Both Cancer Pain and Postoperative Pain [PDF]

Pain Medicine, 2017
Despite the widespread use of opioids for the treatment of cancer pain, results from several surveys consistently show that pain is still prevalent in some patients with malignant diseases. The purinergic P2Y12 receptor is a primary site leading to microglial activation and hyperalgesic pain behaviors and is considered a key regulator in the prevention
Masahiko, Sumitani, Daisuke, Nishizawa, Makoto, Nagashima, Kazutaka, Ikeda, Hiroaki, Abe, Ryoji, Kato, Hiroshi, Ueda, Yoshitsugu, Yamada   +7 more
openaire   +2 more sources

P2Y12 Receptor Antagonist Clopidogrel Attenuates Lung Inflammation Triggered by Silica Particles

Frontiers in Pharmacology, 2020
Silicosis is an occupational lung disease caused by inhalation of silica particles. It is characterized by intense lung inflammation, with progressive and irreversible fibrosis, leading to impaired lung function.
Patricia Teixeira Santana, Tatiana Luna-Gomes, Marcos Vinicius Rangel-Ferreira, Augusto Shuiti Tamura, Carolyne Lalucha Alves Lima Da Graça, Mariana Nascimento Machado, Walter Araujo Zin, Christina Maeda Takiya, Debora Souza Faffe, Robson Coutinho-Silva   +9 more
doaj   +1 more source

Role of Purinergic Receptor Expression and Function for Reduced Responsiveness to Adenosine Diphosphate in Washed Human Platelets. [PDF]

PLoS ONE, 2016
BACKGROUND:Washing of platelets is an important procedure commonly used for experimental studies, e.g. in cardiovascular research. As a known phenomenon, responsiveness to adenosine diphosphate (ADP) is reduced in washed platelets, although underlying ...
Juergen Koessler, Stephanie Hermann, Katja Weber, Angela Koessler, Sabine Kuhn, Markus Boeck, Anna Kobsar   +6 more
doaj   +1 more source

Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 ReceptorSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Chronic abdominal pain is a common symptom of inflammatory bowel diseases (IBDs). Peripheral and central mechanisms contribute to the transition from acute to chronic pain during active disease and clinical remission.
Manon Defaye, Nasser S. Abdullah, Mircea Iftinca, Ahmed Hassan, Francina Agosti, Zizhen Zhang, Melissa Cumenal, Gerald W. Zamponi, Christophe Altier   +8 more
doaj   +1 more source

Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery

Molecules, 2012
Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves, Valber Frutuoso, Leonardo Ferreira, Rômulo Bezerra, Robson Faria   +4 more
doaj   +1 more source

ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12 [PDF]

Cell Death & Disease, 2019
AbstractMelanoma immunotherapy is still not satisfactory due to immunosuppressive cell populations within the tumor stroma. Targeting tumor-associated macrophages (TAM) can help to restore an anti-tumor immunity. Previously, we could show that classical TAM markers expressed in vivo need a 7 day M-CSF/dexamethasone/IL-4 (MDI) stimulation for their ...
Kloss, Loreen, Dollt, Claudia, Schledzewski, Kai, Krewer, Andreas, Melchers, Susanne, Manta, Calin, Sticht, Carsten, Torre, Carolina de la, Utikal, Jochen, Umansky, Viktor, Schmieder, Astrid   +10 more
openaire   +2 more sources