Results 21 to 30 of about 550,877 (189)
Cell & Bioscience, 2023 Background Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer’s disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity.
Subashchandrabose Chinnathambi +1 more
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Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment
BMC Biology, 2023 Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis. While P2Y12-R
Agnès Ribes +8 more
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Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors
Frontiers in Endocrinology, 2021 Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides that contribute to the regulation of intestinal motility and secretion, exocrine and endocrine secretions, and homeostasis of the ...
Ingrid Langer, Dorota Latek
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Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response
PLOS ONE, 2015 Identifying new target molecules through which eosinophils secrete their stored proteins may reveal new therapeutic approaches for the control of eosinophilic disorders such as host immune responses to parasites. We have recently reported the expression of the purinergic P2Y12 receptor (P2Y12R) in human eosinophils; however, its functional role in this
Muniz, Valdirene S. +12 more
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Purinergic signaling in the gastrointestinal tract [PDF]
, 2011 Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Geoffrey Burnstock, Burnstock, G
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Mechanisms of astrocytic and microglial purinergic signaling in homeostatic regulation and implications for neurological disease [PDF]
Exploration of NeurosciencePurinergic signaling, mediated by ATP and adenosine receptors, plays a crucial role in cellular communication and homeostasis within the central nervous system (CNS), particularly by regulating synaptic activity, glial cell functions, and neuroplasticity.
Moawiah M Naffaa
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Biomedicines, 2021 Myocardial infarction (MI) is a dramatic event often caused by atherosclerotic plaque erosion or rupture and subsequent thrombotic occlusion of a coronary vessel.
Maria Cristina Procopio +9 more
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Structure of Purinergic P2Y12 Receptors and some aspects of their biochemistry
, 2020 Abstract The goal of this study is to develop a more rigorous understanding of the P2Y12 receptor first described in blood platelets where it plays a central role in the complex processes of activation and aggregation. P2Y12 receptors are 7-membrane-spanning proteins coupled to G proteins, which are activated by nucleotides, extracellular signaling ...
Shevchenko, Tatyana S. +4 more
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Purinergic Signalling: Therapeutic Developments
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
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Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Tasker, Paul N. +3 more
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