Results 21 to 30 of about 6,211 (154)
Cell & Bioscience, 2023 Background Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer’s disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity.
Subashchandrabose Chinnathambi +1 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The tumor microenvironment plays a major role in the ability of the tumor cells to undergo metastasis. A major player of tumors gaining metastatic property is the inflammatory protein, cyclooxygenase 2 (COX-2).
Shilpa Sharma +2 more
doaj +1 more source
Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment
BMC Biology, 2023 Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis. While P2Y12-R
Agnès Ribes +8 more
doaj +1 more source
Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors
Frontiers in Endocrinology, 2021 Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides that contribute to the regulation of intestinal motility and secretion, exocrine and endocrine secretions, and homeostasis of the ...
Ingrid Langer, Dorota Latek
doaj +1 more source
Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response
PLOS ONE, 2015 Identifying new target molecules through which eosinophils secrete their stored proteins may reveal new therapeutic approaches for the control of eosinophilic disorders such as host immune responses to parasites. We have recently reported the expression of the purinergic P2Y12 receptor (P2Y12R) in human eosinophils; however, its functional role in this
Muniz, Valdirene S. +12 more
openaire +6 more sources
Mechanisms of astrocytic and microglial purinergic signaling in homeostatic regulation and implications for neurological disease [PDF]
Exploration of NeurosciencePurinergic signaling, mediated by ATP and adenosine receptors, plays a crucial role in cellular communication and homeostasis within the central nervous system (CNS), particularly by regulating synaptic activity, glial cell functions, and neuroplasticity.
Moawiah M Naffaa
doaj +1 more source
Structure of Purinergic P2Y12 Receptors and some aspects of their biochemistry
, 2020 Abstract The goal of this study is to develop a more rigorous understanding of the P2Y12 receptor first described in blood platelets where it plays a central role in the complex processes of activation and aggregation. P2Y12 receptors are 7-membrane-spanning proteins coupled to G proteins, which are activated by nucleotides, extracellular signaling ...
Shevchenko, Tatyana S. +4 more
openaire +1 more source
Purinergic Signalling: Therapeutic Developments
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj +1 more source
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Cells, 2020 Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes +4 more
doaj +1 more source
Animals, 2023 The bovine endometrium has an important defensive role in the postpartum period that acts when an inflammatory process associated with tissue damage or infection by bacteria is produced.
Noemí Gutierrez +4 more
doaj +1 more source