G-protein coupled purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodeling in microglia [PDF]
European Journal of Cell Biology, 2022 In Alzheimer’s disease, the microtubule-associated protein, Tau misfolds to form aggregates and filaments in the intra- and extracellular region of neuronal cells. Microglial cells are the resident brain macrophage cells involved in constant surveillance
Hariharakrishnan Chidambaram +2 more
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Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
, 2005 Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn +2 more
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Purinergic receptors and atherosclerosis: emerging role for vessel wall P2Y12 [PDF]
Cardiovascular Research, 2014 This editorial refers to ‘Vessel wall, not platelet, P2Y12 potentiates early atherogenesis’ by L.E. West et al. , doi:10.1093/cvr/cvu028. Platelets play a key role in primary haemostasis and also represent an important interface between thrombosis, immunity, and atherogenesis.1 Platelet-triggered inflammatory pathways contribute to the formation of ...
Bernhard H, Rauch, János G, Filep
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Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]
, 2007 Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
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Expression and function of purinergic P2Y12 receptors in rat trigeminal ganglion neurons [PDF]
Neuroscience Research, 2015 Purinergic receptors play key signaling roles in neuropathic pain in the orofacial region, which is innervated by trigeminal ganglion (TG) neurons. The neuropathology of purinergic P2Y12 receptors is well characterized in glia; however, their physiological role in TG neurons remains to be fully elucidated.
Kawaguchi, A +5 more
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Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function [PDF]
JCI Insight, 2019 Abnormalities in purine availability or purinergic receptor density are commonly seen in patients with lower urinary tract symptoms (LUTS), but the underlying mechanisms relating altered receptor function to LUTS are unknown. Here we provide extensive evidence for the reciprocal interplay of multiple receptors responding to ATP ...
Yuan Hao +6 more
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Purinergic signalling pathway: therapeutic target in ovarian cancer
Egyptian Journal of Medical Human Genetics, 2020 Background The lack of early diagnostic tools and the development of chemoresistance have made ovarian cancer (OC) one of the deadliest gynaecological cancers.
Nisha Chandran +4 more
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eLife, 2022 The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis.
Amit Jairaman +12 more
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Frontiers in Pharmacology, 2021 The tumor microenvironment plays a major role in the ability of the tumor cells to undergo metastasis. A major player of tumors gaining metastatic property is the inflammatory protein, cyclooxygenase 2 (COX-2).
Shilpa Sharma +2 more
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Purinergic signaling in the peripheral vestibular system [PDF]
, 2022 The inner ear comprises the cochlea and vestibular system, which detect sound and acceleration stimulation, respectively. The function of the inner ear is regulated by ion transport activity among sensory epithelial cells, neuronal cells, non-sensory ...
최재영, 김성헌
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