Results 11 to 20 of about 6,211 (154)

Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Is Associated With Lower Opioid Consumption and a Reduced Incidence of Delirium in Cancer Patients Receiving Chemotherapy: A Nationwide Retrospective Cohort Study in Japan. [PDF]

Neuropsychopharmacol Rep
Clopidogrel use was associated with reduced opioid consumption, lower use of other analgesics, and a decreased incidence of hyperactive delirium compared with aspirin in cancer patients receiving chemotherapy, suggesting a potential analgesic effect possibly linked to P2Y12 receptor inhibition.
Abe H, Inoue R, Kogure T, Tsuchida R, Owada H, Sudo Y, Yokoshima Y, Matsui H, Yasunaga H, Sumitani M.   +9 more
europepmc   +2 more sources

SARS-CoV-2 Spike protein alters microglial purinergic signaling

Frontiers in Immunology, 2023
Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of ...
Vinícius Santos Alves, Stephanie Alexia Cristina Silva Santos, Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Renata Rodrigues dos Reis, Mariana L. Calazans, Gabriel Gripp Fernandes, Leticia Silva Antônio, Emanuelle V. de Lima, Eleonora Kurtenbach, Jerson Lima Silva, Fabricia Lima Fontes-Dantas, Fabricia Lima Fontes-Dantas, Giselle Fazzioni Passos, Cláudia Pinto Figueiredo, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +16 more
doaj   +1 more source

Purinergic signaling: A gatekeeper of blood-brain barrier permeation

Frontiers in Pharmacology, 2023
This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Yuemei Wang, Yuanbing Zhu, Junmeng Wang, Longcong Dong, Shuqing Liu, Sihui Li, Qiaofeng Wu   +6 more
doaj   +1 more source

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders

Brain Sciences, 2023
Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec, Anna Wilkaniec, Marta Matuszewska, Ewelina Pałasz, Magdalena Cieślik, Agata Adamczyk   +5 more
doaj   +1 more source

Purinergic receptors and atherosclerosis: emerging role for vessel wall P2Y12 [PDF]

Cardiovascular Research, 2014
This editorial refers to ‘Vessel wall, not platelet, P2Y12 potentiates early atherogenesis’ by L.E. West et al. , doi:10.1093/cvr/cvu028. Platelets play a key role in primary haemostasis and also represent an important interface between thrombosis, immunity, and atherogenesis.1 Platelet-triggered inflammatory pathways contribute to the formation of ...
Bernhard H, Rauch, János G, Filep
openaire   +2 more sources

Expression and function of purinergic P2Y12 receptors in rat trigeminal ganglion neurons [PDF]

Neuroscience Research, 2015
Purinergic receptors play key signaling roles in neuropathic pain in the orofacial region, which is innervated by trigeminal ganglion (TG) neurons. The neuropathology of purinergic P2Y12 receptors is well characterized in glia; however, their physiological role in TG neurons remains to be fully elucidated.
Kawaguchi, A, Sato, M, Kimura, M, Ichinohe, T, Tazaki, M, Shibukawa, Y   +5 more
openaire   +3 more sources

Identification of a carbohydrate recognition motif of purinergic receptors

eLife, 2023
As a major class of biomolecules, carbohydrates play indispensable roles in various biological processes. However, it remains largely unknown how carbohydrates directly modulate important drug targets, such as G-protein coupled receptors (GPCRs).
Lifen Zhao, Fangyu Wei, Xinheng He, Antao Dai, Dehua Yang, Hualiang Jiang, Liuqing Wen, Xi Cheng   +7 more
doaj   +1 more source

Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function [PDF]

JCI Insight, 2019
Abnormalities in purine availability or purinergic receptor density are commonly seen in patients with lower urinary tract symptoms (LUTS), but the underlying mechanisms relating altered receptor function to LUTS are unknown. Here we provide extensive evidence for the reciprocal interplay of multiple receptors responding to ATP ...
Yuan Hao, Lu Wang, Huan Chen, Warren G. Hill, Simon C. Robson, Mark L. Zeidel, Weiqun Yu   +6 more
openaire   +2 more sources

Purinergic signalling pathway: therapeutic target in ovarian cancer

Egyptian Journal of Medical Human Genetics, 2020
Background The lack of early diagnostic tools and the development of chemoresistance have made ovarian cancer (OC) one of the deadliest gynaecological cancers.
Nisha Chandran, Mahalaxmi Iyer, Zothan Siama, Balachandar Vellingiri, Arul Narayanasamy   +4 more
doaj   +1 more source

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

eLife, 2022
The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis.
Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan   +12 more
doaj   +1 more source