Results 1 to 10 of about 4,477 (97)

Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

Computational and Structural Biotechnology Journal, 2023
Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han, Hongryul Yoon, Jiho Yoo, Yoonji Lee   +3 more
doaj   +3 more sources

Pharmacological Nature of the Purinergic P2Y Receptor Subtypes That Participate in the Blood Pressure Changes Produced by ADPβS in Rats

Pharmaceuticals, 2023
Purine nucleosides (adenosine) and nucleotides such as adenosine mono/di/triphosphate (AMP/ADP/ATP) may produce complex cardiovascular responses. For example, adenosine-5′-(β-thio)-diphosphate (ADPβS; a stable synthetic analogue of ADP) can induce ...
Roberto C. Silva-Velasco, Belinda Villanueva-Castillo, Kristian A. Haanes, Antoinette MaassenVanDenBrink, Carlos M. Villalón   +4 more
doaj   +1 more source

New Insights in Purinergic Therapy: Novel Antagonists for UTP-Activated P2Y Receptors from Natural Products

Journal of Medicinal Food, 2018
P2Y2 and P2Y4 receptors are physiologically activated by UTP and are widely expressed in many cell types in humans. They promote an increase in intracellular calcium via PLCβ/ IP3 and act on ion flux and water secretion. P2Y2 plays an important role in inflammation and proliferation of tumor cells, which could be attenuated with the use of ...
Natiele Carla da Silva Ferreira, Romulo José Soares-Bezerra, Rebeca Ferreira Couto da Silveira, Clayton Menezes da Silva, Carla Santos de Oliveira, Andrea Calheiros Surrage, Tânia Maria Alves, Carlos Leomar Zani, Luiz Alves   +8 more
openaire   +4 more sources

Impact of morphine dose on ticagrelor uptake and platelet inhibition in patients with ST-segment elevation myocardial infarction – A substudy from the prospective randomized MOVEMENT trial

Thrombosis Update, 2021
Background: Morphine delays ticagrelor effect in ST-segment elevation myocardial infarction (STEMI) patients, likely due to impaired gastrointestinal motility.
Manne Holm, Per Tornvall, Olof Beck, Thomas Fux, Jan van der Linden   +4 more
doaj   +1 more source

In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors

Biomolecules, 2020
Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj   +1 more source

Unlocking the Conformational Changes of P2Y₁₂: Exploring an Acridinone Compound’s Effect on Receptor Activity and Conformation

Molecules, 2023
The P2Y12 receptor is an important member of the purinergic receptor family, known for its critical role in platelet activation and thrombosis. In our previously published study, the acridinone analogue NSC618159 was identified as a potent antagonist of ...
Belal O. Al-Najjar, Fadi G. Saqallah
doaj   +1 more source

Postoperative Bleeding Risk after Gastric Endoscopic Submucosal Dissection in Patients Receiving a P2Y12 Receptor Antagonist

Gut and Liver, 2023
Background/Aims: The safety of gastric endoscopic submucosal dissection (ESD) in users of a P2Y12 receptor antagonist (P2Y12RA) under current guidelines has not been verified.
Ryosuke Hirai, Seiji Kawano, Shoko Inoo, Sakiko Kuraoka, Shotaro Okanoue, Takuya Satomi, Kenta Hamada, Yoshiyasu Kono, Hiromitsu Kanzaki, Masaya Iwamuro, Yoshiro Kawahara, Hiroyuki Okada   +11 more
doaj   +1 more source

Differential Expression of the Metabotropic P2Y Receptor Family in the Cortex Following Status Epilepticus and Neuroprotection via P2Y1 Antagonism in Mice

Frontiers in Pharmacology, 2020
Purinergic signaling via P2 receptors is now widely accepted to play a critical role during increased states of hyperexcitability and seizure-induced pathology.
Mariana Alves, Jonathon Smith, Jonathon Smith, Tobias Engel, Tobias Engel   +4 more
doaj   +1 more source

Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. [PDF]

PLoS ONE, 2015
Infection by the protozoan parasite Toxoplasma gondii is highly prevalent worldwide and may have serious clinical manifestations in immunocompromised patients. T. gondii is an obligate intracellular parasite that infects almost any cell type in mammalian
Aline Cristina Abreu Moreira-Souza, Ygor Marinho, Gladys Correa, Giani França Santoro, Claudia Mara Lara Melo Coutinho, Rossiane Claudia Vommaro, Robson Coutinho-Silva   +6 more
doaj   +1 more source

Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y₁₂ Receptor Antagonists

Molecules, 2019
Large inter-individual variation in platelet response to endogenous agonists and pharmacological agents, including resistance to antiplatelet therapy, prompts a search for novel platelet inhibitors and development new antithrombotic strategies.
Nina Wolska, Magdalena Boncler, Dawid Polak, Joanna Wzorek, Tomasz Przygodzki, Magdalena Gapinska, Cezary Watala, Marcin Rozalski   +7 more
doaj   +1 more source