Results 61 to 70 of about 27,659 (185)

Unprotected Left Main Disease: Clinical Outcomes Following Deferral, Coronary Artery Bypass Grafting, or Percutaneous Coronary Intervention

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The prognostic benefit of revascularization for unprotected left main (LM) disease remains uncertain, as guideline endorsement of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) precludes comparison with deferral, which is unlikely to be assessed in a randomized trial.
Marc Meller Bröchner, Evald Høj Christiansen, Kristian Kragholm, Lisette Okkels Jensen, Gennady Atroshchenko, Ivy Susanne Modrau, Lars Riber, Oliver Buchhave Pedersen, Leif Thuesen, Christian Torp‐Pedersen, Ashkan Eftekhari   +10 more
wiley   +1 more source

P2Y12 inhibitor use predicts hematoma expansion in patients with intracerebral hemorrhage

Annals of Clinical and Translational Neurology
Objective Hematoma expansion (HE) predicts disability and death after acute intracerebral hemorrhage (ICH). Aspirin and anticoagulants have been associated with HE. We tested the hypothesis that P2Y12 inhibitors predict subsequent HE in patients.
Ethan J. Houskamp, Yuzhe Liu, Juliana Silva Pinheiro do Nascimento, Babak S. Jahromi, Paul F. Lindholm, Hau C. Kwaan, Andrew M. Naidech   +6 more
doaj   +1 more source

P2Y12 inhibitor monotherapy after complex percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials

Scientific Reports, 2023
It remains unknown whether the recent trend of short dual antiplatelet therapy (DAPT) followed by P2Y12 inhibitor monotherapy can simply be applied to patients undergoing complex percutaneous coronary intervention (PCI).
Yohei Sotomi, Yuki Matsuoka, Shungo Hikoso, Daisaku Nakatani, Katsuki Okada, Tomoharu Dohi, Hirota Kida, Bolrathanak Oeun, Akihiro Sunaga, Taiki Sato, Tetsuhisa Kitamura, Yasushi Sakata   +11 more
doaj   +1 more source

Polimorfisme P2Y12 Terhadap Agregasi Platelet Pada Pasien Penyakit Jantung Koroner

, 2019
Genetic polymorphism of P2Y12 receptor is one of the factors responsible for the variation in response to antiplatelet therapy. Variations in response to P2Y12 receptors can cause Coronary Artheri Disease (CAD) in CHD patients.
hermawatiningsih, oktaviarika dewi
core   +1 more source

Spatial Mismatch Between Angiographic Obstruction and Plaque Destabilization in Acute Coronary Syndromes: A Conceptual Narrative Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The identification of the “culprit lesion” in acute coronary syndromes (ACS) traditionally relies on coronary angiography, assuming that the most severe stenosis, abrupt occlusion, or largest filling defect marks the site of plaque destabilization.
Fernando Quevedo‐Candela, Olivier F. Bertrand, Pedro Cepas‐Guillén, Jean‐Pierre Déry, David García‐Labbé, Andrés Ruhl, Eduardo Flores‐Umanzor, Tomas Cieza   +7 more
wiley   +1 more source

The influence of variation in the P2Y12 receptor gene on in vitro platelet inhibition with the direct P2Y12 antagonist cangrelor

, 2010
Novel P2Y12 inhibitors are in development to overcome the occurrence of atherothrombotic events associated with poor responsiveness to the widely used P2Y12 inhibitor clopidogrel.
van Werkum, JW, Kruit, A, de Maat, Moniek; id_orcid, Rudez, Goran, Leebeek, Frank, Bouman, HJ, van den Berg, JM, Leebeek, Frank; id_orcid, Hackeng, CM, de Maat, Moniek, Ruven, HJT   +10 more
core   +1 more source

Early P2Y12 Inhibitors Escalation in Primary PCI Patients: Insights from the RENOVAMI Registry [PDF]

, 2018
Background Early escalation from clopidogrel to new generation P2Y12 inhibitors is common practice in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI).
Emanuele Meliga, Luigina Guasti, Alessandro Lupi, Bona, Roberta Della, Capodanno, Davide, Alon Schaffer, Roberta Bona, Porto I, Meliga, Emanuele, Dimitrios Alexopoulos, Davide Capodanno, Marco Valgimigli, Lupi A, Bongo, Angelo S., Lupi, Alessandro, Guasti L, Bongo AS, Della Bona R, Gaudio G, Guasti, Luigina, Capodanno D, Alexopoulos D, Alexopoulos, Dimitrios, Giovanni Gaudio, Meliga E, Bongo, Angelo S, Schaffer A, Italo Porto, Valgimigli M, Schaffer, Alon, Angelo Bongo, Porto, Italo, Gaudio, Giovanni, Valgimigli, Marco   +33 more
core   +1 more source

Diagnostic Agreement and Threshold Correspondence Between Resting Full‐Cycle Ratio and Nicorandil‐Based Fractional Flow Reserve in Intermediate Coronary Stenosis: A Prospective Single‐Center Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background RFR has shown good aggregate agreement with FFR, including in prior Asian cohorts using intracoronary nicorandil. Where RFR‐FFR disagreement is concentrated relative to the FFR 0.80 decision boundary, and how the two binary thresholds correspond, remain incompletely characterized. Methods In a prospective single‐center registry, 300
Yonghoon Shin, Onyou Kim, Gi Won Yu, Yun Won Lee, Jung‐Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu   +8 more
wiley   +1 more source

The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration

Platelets, 2022
Here, we report the in vitro characterization of the P2Y12 receptor antagonist selatogrel (ACT-246475). Binding studies with radiolabeled selatogrel demonstrated that selatogrel is a competitive antagonist of ADP binding to the P2Y12 receptor with a fast
Martine Baumann, Benoît Lack, Isabelle Guillaumat, Mark J. Murphy, Markus A. Riederer   +4 more
doaj   +1 more source

The in‐hospital administration of sacubitril/valsartan in acute myocardial infarction: A meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 998-1012, April 2025.
In patients with Acute Myocardial Infarction related heart failure, the in‐hospital administration of ARNIs was associated with a reduced risk of MACEs and re‐hospitalizations for heart failure, as well as cardiac remodeling, compared to standard therapy.
Gianluca Di Pietro, Riccardo Improta, Paolo Severino, Andrea D'Amato, Lucia Ilaria Birtolo, Ovidio De Filippo, Antonio Lattanzio, Raffaele De Cristofaro, Giacchino Galardo, Fabrizio D'Ascenzo, Roberto Badagliacca, Gennaro Sardella, Maurizio Volterrani, Francesco Fedele, Carmine Dario Vizza, Massimo Mancone   +15 more
wiley   +1 more source