Results 61 to 70 of about 25,852 (233)

Identification of a New Morpholine Scaffold as a P2Y12 Receptor Antagonist

Molecules, 2016
The P2Y12 receptor is critical for platelet activation and is an attractive drug target for the prevention of atherothrombotic events. Despite the proven antithrombotic efficacy of P2Y12 inhibitors, these thienopyridine scaffolds are prodrugs that lack ...
Young Ha Ahn, Joo-Youn Lee, Hee Dong Park, Tae Hun Kim, Min Chul Park, Gildon Choi, Sunghoon Kim   +6 more
doaj   +1 more source

Global antiplatelet sales trend: A focus on P2Y12 inhibitors from 2008 to 2018

American Heart Journal Plus, 2021
Background: P2Y12 inhibitors are an important component of dual antiplatelet therapy. Yet, their accessibility and affordability across countries stratified by income levels have not been studied.
Xuxiao Ye, Jessica J.P. Shami, Vincent K.C. Yan, Wei Kang, Joseph E. Blais, Jiaxi Zhao, Wallis C.Y. Lau, Li Wei, Ian C.K. Wong, Esther W. Chan   +9 more
doaj   +1 more source

Standardization of measurement and reporting of medication adherence using the TEN‐SPIDERS tool for claims data

British Journal of Clinical Pharmacology, EarlyView.
This study provides the first open‐source tool to implement the complete TEN‐SPIDERS framework in linked datasets for the determination of the PDC for medication adherence. The TEN‐SPIDERS tool enables transparent, reproducible medication adherence research through automated reporting of all calculation parameters and flexible customization options ...
Adam C. Livori, Tzu‐Yung Kuo, Jenni Ilomäki, Monique F. Kilkenny, Stella Talic, Zanfina Ademi, J. Simon Bell, Jedidiah I. Morton, Lachlan L. Dalli   +8 more
wiley   +1 more source

Insights into platelet P2Y12 receptor activation [PDF]

Blood, 2015
In this issue of Blood , Lecchi et al report that lifelong abnormal bleeding episodes in 2 brothers are the result of a homozygous mutation in the gene encoding the P2Y12 receptor that disrupts adenosine diphosphate (ADP)–promoted platelet aggregation.[1][1] ![Figure][2] ADP ...
openaire   +2 more sources

P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia [PDF]

, 2017
Pei-Wen Liu,* Ming-Xia Yue,* Rui Zhou, Juan Niu, Du-Juan Huang, Tao Xu, Pei Luo, Xiao-Hong Liu, Jun-Wei Zeng Department of Physiology, Zunyi Medical College, Guizhou, China *These authors contributed equally to ...
Liu X, Huang D, Luo P, Zhou R, Liu P, Niu J, Xu T, Zeng J, Yue M   +8 more
core  

Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation

BMC Cardiovascular Disorders, 2023
Background The objective of this study was to investigate the relationship between P2Y1 and P2Y12 genotypes and the risk of acute myocardial infarction (AMI) in the Quanzhou population and to determine associations between P2Y1 and P2Y12 genotypes and ...
Chunyan Su, Zhishan Zhang, Jintu Chen, Mengcha Tian, Conglian Wu, Tao Zhang   +5 more
doaj   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Baicalin Depresses the Sympathoexcitatory Reflex Induced by Myocardial Ischemia via the Dorsal Root Ganglia

Frontiers in Physiology, 2018
Myocardial ischemia (MI) is one of the major causes of death in cardiac diseases. Purinergic signaling is involved in bidirectional neuronal-glial communication in the primary sensory ganglia.
Lifang Zou, Lifang Zou, Xinyao Han, Shuangmei Liu, Shuangmei Liu, Yingxin Gong, Bing Wu, Bing Wu, Zhihua Yi, Zhihua Yi, Hui Liu, Hui Liu, Shanhong Zhao, Shanhong Zhao, Tianyu Jia, Tianyu Jia, Lin Li, Lin Li, Huilong Yuan, Huilong Yuan, Liran Shi, Liran Shi, Chunping Zhang, Chunping Zhang, Yun Gao, Yun Gao, Guilin Li, Guilin Li, Hong Xu, Hong Xu, Shangdong Liang, Shangdong Liang   +31 more
doaj   +1 more source

Clinical and Echocardiographic Outcomes After Implantation of the ALLEGRA Transcatheter Valve Using the Fully Repositionable IMPERIA Delivery System: One‐Year Results of the EMPIRE I Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The EMPIRE I study assessed the early (30 days) safety and efficacy of a new fully repositionable delivery system (IMPERIA) for the commercially available ALLEGRA transcatheter aortic valve in patients with either severe native aortic stenosis or a degenerated surgical bioprosthesis.
José Antonio Baz, Claire B. Ren, Christof Burgdorf, Christian Frerker, Ignacio Cruz‐González, Joan Antoni Gómez, José Maria Hernândez, Pilar Jimenez, Ernest Spitzer, Pim Tonino, Pieter Vriesendorp, Nicolas van Mieghem, Samuel Copt, Anders Jönsson, Keith G. Oldroyd, Nicolas Doll   +15 more
wiley   +1 more source

Role of Neuroimaging Before Coronary Angiography in Patients With Out‐of‐Hospital Cardiac Arrest

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Patients presenting following out‐of‐hospital cardiac arrest (OOHCA) often require emergency coronary angiography. Presentations can be associated with syncope or head‐trauma. Aims We investigated the impact and utility of pre‐coronary angiography CT‐Brain (CT‐B) in patients following OOHCA on clinical outcomes.
Edmond Wong, Kathryn Yu, Davide Tomassoni, Timothy Scully, Timothy Yeung, Jennifer Cooke, David Tong, Jaya Chandrasekhar, Jason Nogic   +8 more
wiley   +1 more source