Results 81 to 90 of about 35,993 (244)
Journal of Hospital Medicine, EarlyView.Abstract Background The Veterans Health Administration (VA) cares for more than one million hospitalized Veterans each year. There is limited knowledge on how hospital medicine care in VA facilities compares with non‐VA hospitals in terms of the Institute of Medicine domains of healthcare access, patient experience, quality, clinical outcomes, and cost.
Paul G. Shekelle +4 more
wiley +1 more source
ADP exerts P2Y12 -dependent and P2Y12 -independent effects on primary human T cell responses to stimulation [PDF]
Journal of Cell Communication and Signaling, 2019 Purinergic signaling plays a complex role in inflammation. Nucleotides released by T lymphocytes, endothelial cells, and platelets during inflammation induce cellular responses by binding to receptors that regulate intracellular signaling pathways. Previous studies have found that purinergic signaling can have both proinflammatory and anti-inflammatory
Harika Vemulapalli +5 more
openaire +2 more sources
Platelets, 2017 Patients on P2Y12 inhibitors may still develop thrombosis or bleeding complications. Tailored antiplatelet therapy, based on platelet reactivity testing, might reduce these complications.
Tesse C. Leunissen +11 more
doaj +1 more source
Contemporary NSTEMI management: the role of the hospitalist. [PDF]
, 2019 Non-ST-segment elevation myocardial infarction (NSTEMI) is defined as elevated cardiac biomarkers of necrosis in the absence of persistent ST-segment elevation in the setting of anginal symptoms or other acute event.
Amin, Alpesh +9 more
core +1 more source
Precision Medical Sciences, EarlyView.Central illustration: Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement. Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis.
Muhammad Huzaifa Ahmed Khan +12 more
wiley +1 more source
Platelet G i protein Gα i2 is an essential mediator of thrombo-inflammatory organ damage in mice [PDF]
, 2015 Platelets are crucial for hemostasis and thrombosis and exacerbate tissue injury following ischemia and reperfusion. Important regulators of platelet function are G proteins controlled by seven transmembrane receptors.
Beer-Hammer, Sandra +13 more
core +1 more source
Precision Medical Sciences, EarlyView.Fractional Flow Reserve versus Intravascular Ultrasound for guiding percutaneous coronary intervention in coronary artery disease: A systematic review and meta‐analysis of 5 studies (over 3,900 patients) showing comparable outcomes in MACE, mortality, and target vessel revascularization.
Sanket Patel +13 more
wiley +1 more source
Morphine Analgesia Pre-PPCI Is Associated with Prothrombotic State, Reduced Spontaneous Reperfusion and Greater Infarct Size [PDF]
, 2017 Schattauer GmbH Stuttgart.The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, which
Farag, Mohamed +5 more
core +2 more sources
Anaesthesia, EarlyView.Summary Introduction Patients who require major vascular surgery often receive antiplatelet therapy for primary or secondary prevention of cardiovascular disease. Clopidogrel resistance and variability in platelet recovery after drug discontinuation pose clinical challenges, particularly for regional anaesthesia and blood management.
Akshay Shah +11 more
wiley +1 more source
Human brain matters: Navigating the neuropathology of COVID‐19
Brain Pathology, EarlyView.Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland +4 more
wiley +1 more source