Results 81 to 90 of about 27,659 (185)

Comparative Long-Term Effect of Three Anti-P2Y12 Drugs after Percutaneous Angioplasty: An Observational Study Based on Electronic Drug Adherence Monitoring

Frontiers in Pharmacology, 2017
Aims: Dual platelet inhibition using anti-P2Y12 drugs and aspirin is the standard of care in patients after percutaneous coronary interventions (PCI). Prasugrel and ticagrelor have been shown to be more potent than clopidogrel with less high on-treatment
Valentina Forni Ogna, Isabelle Bassi, Isabelle Menetrey, Olivier Muller, Eric Tousset, Pierre Fontana, Pierre Fontana, Eric Eeckhout, Chin B. Eap, Chin B. Eap, Bernard Vrijens, Michel Burnier, Grégoire Wuerzner   +12 more
doaj   +1 more source

Prospective randomised double‐blind trial: holmium laser lithotripsy with vs without Moses™ 2.0

BJU International, EarlyView.
Objective To assess the effect of Moses™ 2.0 (Lumenis Be Ltd., Yokneam Illit, Israel; Boston Scientific, Marlborough, MA, USA) for lithotripsy of renal stones of 8–20 mm in diameter on operative time, surgeon workload, and retropulsion. Subjects/Patients and Methods In our multicentre, randomised, double‐blind clinical trial, patients were randomised 1:
Kimberly A. Maciolek, Naren Nimmagadda, Aaron X. Lee, Amy M. Reed, Ryan S. Hsi, Tatsuki Koyama, Connor M. Forbes, Matthew S. Lee, Cyrus Chehroudi, Ezra J. Margolin, Ben H. Chew, Seth K. Bechis, Mitchell R. Humphreys, Michael E. Lipkin, Manoj Monga, Ojas Shah, Karen L. Stern, Roger L. Sur, Sri Sivalingam, Nicole L. Miller   +19 more
wiley   +1 more source

Knockout of P2Y12 receptor facilitates neuronal envelopment by reactive microglia and accelerates prion disease

Journal of Neuroinflammation
Background Microglia continuously monitor neuronal health through somatic purinergic junctions, where microglial processes establish dynamic contacts with neuronal cell bodies.
Natallia Makarava, Tarek Safadi, Olga Bocharova, Olga Mychko, Narayan P. Pandit, Kara Molesworth, Ukpong B. Eyo, Ilia V. Baskakov   +7 more
doaj   +1 more source

Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12 and P2Y13 receptors in neuropathic pain rats

Journal of Neuroinflammation, 2017
Background More evidence suggests that dorsal spinal cord microglia is an important site contributing to CB2 receptor-mediated analgesia. The upregulation of P2Y12 and P2Y13 purinoceptors in spinal dorsal horn microglia is involved in the development of ...
Juan Niu, Dujuan Huang, Rui Zhou, MingXia Yue, Tao Xu, Junna Yang, Li He, Hong Tian, XiaoHong Liu, Junwei Zeng   +9 more
doaj   +1 more source

P2Y12 inhibitors

, 2009
SummaryThe P2Y12 receptor has proven to be a key target in the prevention of complications associated with atherosclerotic vascular disease especially in the context of acute coronary syndrome and percutaneous coronary intervention in addition to aspirin.
J.-P. Collet, G. Montalescot
core   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

РАННЕЕ НАЗНАЧЕНИЕ ИНГИБИТОРОВ P2Y12-РЕЦЕПТОРОВ ТРОМБОЦИТОВ БОЛЬНЫМ С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ: ПОЛЬЗА ИЛИ ВРЕД? [PDF]

, 2018
Double antiplatelet therapy, which includes aspirin and platelet P2Y12 receptor inhibitors (hereinafter P2Y12 inhibitor) is the main component of treatment and secondary prevention after ACS.
Р. М. Шахнович, Roman M. Shakhnovich   +1 more
core   +1 more source

ALOX15 links lipid metabolism to receptor trafficking in platelet activation

The FEBS Journal, EarlyView.
This schematic summarizes known and newly identified mechanisms of thrombin‐mediated platelet activation. In addition to classical thrombin‐induced PAR4 signaling pathways, thrombin activates an ALOX15–HETE–PKCθ–NMT1 signaling cascade that promotes protein myristoylation, facilitates receptor trafficking, and enhances PAR4 surface expression on ...
Yosef Eshetie Amare, Sharad Saxena, Serena Zacchigna   +2 more
wiley   +1 more source

P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia

, 2017
Pei-Wen Liu,* Ming-Xia Yue,* Rui Zhou, Juan Niu, Du-Juan Huang, Tao Xu, Pei Luo, Xiao-Hong Liu, Jun-Wei Zeng Department of Physiology, Zunyi Medical College, Guizhou, China *These authors contributed equally to ...
Liu X, Huang D, Luo P, Zhou R, Liu P, Niu J, Xu T, Zeng J, Yue M   +8 more
core  

Pretreatment With P2Y12 Inhibitors in ST-Segment Elevation Myocardial Infarction: Insights From the Bern-PCI Registry. [PDF]

BACKGROUND Evidence to support immediate P2Y12 inhibitor loading in ST-segment elevation myocardial infarction (STEMI) is limited. OBJECTIVES This study sought to compare outcomes of STEMI patients receiving immediate or delayed P2Y12 inhibitor ...
Lanz, Jonas, Windecker, Stephan, Siontis, George Cm, Ye, Shirley Xinyu, Praz, Fabien, Shibutani, Hiroki, Otsuka, Tatsuhiko, Temperli, Fabrice, Stortecky, Stefan, Bär, Sarah, Losdat, Sylvain, Räber, Lorenz, Hunziker, Lukas, Pilgrim, Thomas, Bruno, Jolie, Kavaliauskaite, Raminta, Rohla, Miklos, Häner, Jonas D   +17 more
core   +1 more source