Results 131 to 140 of about 2,942 (201)

Backbone‐Length‐Optimized Inhibitors Deliver Long‐Retention Selectivity in Area‐Selective ALD of VO2

Advanced Science, Volume 13, Issue 45, 13 August 2026.
Area‐selective VO2 ALD is found to depend critically on inhibitor backbone length, which governs physisorption, chemisorption stability, and packing efficiency in a coupled manner. An intermediate backbone‐length achieves the best long‐retention selectivity, establishing a chemically and geometrically grounded design principle for small‐molecule ...
Hae Lin Yang, Eun Chong Cho, Minchan Kim, Hye In Park, Ga‐young Lee, Seunghwan Lee, Beomseok Kim, Changhwa Jung, Youngkwon Kim, Jin‐Seong Park   +9 more
wiley   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution

BioEssays, Volume 48, Issue 8, August 2026.
p53 is an adaptive processor positioned at the interface between metabolism and the tumor microenvironment. By integrating nutrient, mechanical, inflammatory, and redox cues while reciprocally remodeling metabolism, stromal and immune compartments, and cancer cell plasticity, WT and mutant p53 orchestrate cell competition, tumor evolution, metastasis ...
Sebastien M. Joruiz, Francesco Napoletano, Rebecca Bertolio, Giannino Del Sal   +3 more
wiley   +1 more source

Limonene Modulates Event‐Related Potentials in a 2‐Back Working Memory Task

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Introduction Olfactory inputs can influence visual cognition. However, it remains unclear whether such effects are driven by the chemical properties of odorants or by mood‐related associations, especially under conditions of high cognitive demand.
Kaori Tamura, Keitaro Yamashita, Taiki Nishimura, Toko Tatsumoto, Takumi Yano, Yuko Ohno, Shin'ichi Yoshimura, Mitsuo Tonoike   +7 more
wiley   +1 more source

P300-Targeted Acetylome Reveals a Role for HMGB1 Translocation in Central Cardiac Sympathetic Activation Post Myocardial Infarction

Journal of Inflammation Research
Jie Yin,1,2,* Fuhong Liu,2,3,* Huitang Xia,4 Suhua Yan,2 Ye Wang,2 Xinran Li,2 Yugen Shi,2 Yu Wang,2 Yanyan Jing,5 Yan Li,3,6 Hesheng Hu2 1Department of Cardiology, Shandong Provincial Hospital affiliated with Shandong First Medical ...
Yin J, Liu F, Xia H, Yan S, Wang Y, Li X, Shi Y, Wang Y, Jing Y, Li Y, Hu H   +10 more
doaj  

Efficacy and Evidence Certainty of High‐Frequency rTMS for Cognitive Impairment Across Neuropsychiatric Disorders: An Umbrella Review

Brain and Behavior, Volume 16, Issue 8, August 2026.
This umbrella review of 29 meta‐analyses found that HF‐rTMS significantly improves cognition in Alzheimer's disease and vascular cognitive impairment. However, GRADE shows that most evidence is of low‐to‐very‐low certainty, and AMSTAR‐2 rates over 60% of reviews as critically low quality. Well‐designed trials are urgently needed.
Lin‐ling Wu, Xin‐cheng Huang, Juan‐juan Bi, Pei‐yuan He   +3 more
wiley   +1 more source

ROS‐ATM‐CBP axis‐mediated PARP1 lactylation aggravates doxorubicin‐induced cardiotoxicity

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ROS function as signalling molecules to promote CBP‐mediated PARP1 lactylation in an ATM dependent manner, which induces PARP1 PARylation and ultimate cell apoptosis. CBP and SIRT1 as specific lactyltransferase and delactylase of PARP1. Lactylation of PARP1 depends on the LDHA activity and lactate production.
Wenbin Wang, Yingxian Sun
wiley   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source