Results 131 to 140 of about 121,215 (251)

Curcumin Nanoformulations for Dermatological Applications: From Nutraceuticals to Nanocarriers

Food Frontiers, Volume 7, Issue 3, May 2026.
Nanotechnology‐based delivery platforms enhance the cutaneous administration of curcumin. Loading free curcumin into polymeric micelles, metal‐based nanoparticles, nanogels/hydrogels, liposomes, polymeric nanoparticles, or nanoemulsions/nanocrystals helps address its low solubility, poor stability and limited skin permeation. As a result, these systems
Stephany Celeste Gutiérrez‐Ruiz, Alejandra Romero‐Montero, Hector Hernández‐Parra, Sheila I. Peña‐Corona, Héctor Adrián García‐Gasca, Katya Carbone, Fabio Gervasi, Shivaprasad Shetty Mangalpady, Rajesh Kaverikana, Mariia Shanaida, Volodymyr Shanaida, Daniela Calina, Javad Sharifi‐Rad, Gerardo Leyva‐Gómez   +13 more
wiley   +1 more source

Comparison of cell type and disease subset chromatin modifications in SLE

Clinical Epigenetics
Background Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations. There is little understanding of why some organs are specifically impacted in patients and the mechanisms of disease persistence remain unclear.
Katherine Beigel, Xiao-Min Wang, Li Song, Kelly Maurer, Christopher Breen, Deanne Taylor, Daniel Goldman, Michelle Petri, Kathleen E. Sullivan   +8 more
doaj   +1 more source

Heat Transfer Performance of Biphilic Surfaces With Diatomite‐Based Composite Coatings in a Closed Thermosyphon System

Heat Transfer, Volume 55, Issue 3, Page 1608-1638, May 2026.
ABSTRACT This study investigates the thermal performance of innovative biphilic boiling surfaces designed for CPU cooling applications using a two‐phase closed thermosyphon (TPCT) system. The surfaces were fabricated by applying composite coatings—comprising epoxy resin and diatomite particles functionalized with APTES and PFOTS silanes— onto Al1050 ...
José Pereira, Reinaldo Souza, António Moreira, Ana Moita   +3 more
wiley   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Dexamethasone‐Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH‐7 Cells

Fundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Hana Yu, Song Hee Lee, Ji Hyeon Kim, Seung Jin Kim, Hee Eun Kang   +4 more
wiley   +1 more source

From Feedback‐Learning to Semantic Memory: Can Feedback‐Related Brain Activity Predict Object‐Word Associations?

Psychophysiology, Volume 63, Issue 5, May 2026.
ABSTRACT This study investigated the neural mechanisms underlying feedback‐based learning of novel‐object‐novel‐word associations, focusing on how feedback‐locked event‐related potentials acquired during learning relate to subsequent memory performance and acquired association strength.
Christine Albrecht, Laura Bechtold, Marta Ghio, Christian Bellebaum   +3 more
wiley   +1 more source

Explainable AI Insights Into EEG Classification and Its Alignment to Neural Correlates

Human Brain Mapping, Volume 47, Issue 6, April 15, 2026.
We systematically generate, filter, and cluster explanations of deep learning models of EEG data to identify universal patterns of relevance, which we validate via connections to observations from neuroscience. ABSTRACT While deep learning has drastically improved the performance of electroencephalography (EEG) analysis, it remains unclear what these ...
Hendrik Eilts, Gabriel Ivucic, Niklas Koenen, Marvin N. Wright, Tanja Schultz, Felix Putze   +5 more
wiley   +1 more source

E1A binding protein p300 (EP300; p300) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source