Results 131 to 140 of about 71,455 (301)

Modulation of cerebral blood flow and cognition by hyperthermia and hypoxia: An electroencephalographic event‐related potentials perspective

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) is essential for sustaining neuronal metabolism and cognitive performance; however, the precise relationship between perfusion and cognition remains unclear. Although ageing and disease are associated with progressive declines in CBF and cognitive impairment, the acute effects of altered CBF under environmental ...
Hiroki Nakata, Shigehiko Ogoh, Manabu Shibasaki   +2 more
wiley   +1 more source

Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study

Pharmaceuticals
Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional coactivator p300, a critical
Muhammad Suleman, Abrar Mohammad Sayaf, Sohail Aftab, Mohammed Alissa, Abdullah Alghamdi, Suad A. Alghamdi, Mohammed A. Alshehri, Kar Kheng Yeoh, Sergio Crovella, Abdullah A. Shaito   +9 more
doaj   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

P300 AND ALCOHOLISM

, 1998
1999.—The P300 event-related brain potential (ERP) was elicited with auditory and visual stimuli from members of 13 families who were at high risk (HR) for alcoholism (father diagnosed as alcoholic) and 13 families at low risk (LR) for alcoholism.
E. Bloom, Floyd, John Polich
core  

Distinctive neurophysiological correlates of sound onset and offset perception in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Electroencephalography (EEG) recordings were obtained from participants listening to successive pairs of 1‐2 s noises in a silent background (Study 1) or successive pairs 1‐2 s silent gaps in a noise background (Study 2). Participants heard the same stimuli in the context of either a duration discrimination task (identifying ...
Fatima Ali, Gabriela Bury, Adèle Simon, Jennifer F. Linden   +3 more
wiley   +1 more source

p300 localizes in aggresomes.

, 2012
A–C. Cos7 cells were treated with DMSO (A) or treated with 5 µM MG132 for 16 hours (B–C) and cells were stained with a monoclonal mix of anti-ubiquitin (A and B), the anti-p300 polyclonal C20 antibody (A–C), or anti-vimentin monoclonal (C) antibodies ...
Geetaram Sahu (123401), Nagarajan Pattabiraman (123407), Italo Mocchetti (123416), Christopher Albanese (123412), Maria Laura Avantaggiati (123426), Mika Shimoji (123384), Jeffrey A. Toretsky (123418), Alexander Kirilyuk (123377), Antonio Giordano (55096), Vladimir N. Uversky (123421), Jason Catania (123392)   +10 more
core   +1 more source

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, Volume 159, Issue 2, Page 410-422, 15 July 2026.
What's new? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

Comparison of cell type and disease subset chromatin modifications in SLE

Clinical Epigenetics
Background Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations. There is little understanding of why some organs are specifically impacted in patients and the mechanisms of disease persistence remain unclear.
Katherine Beigel, Xiao-Min Wang, Li Song, Kelly Maurer, Christopher Breen, Deanne Taylor, Daniel Goldman, Michelle Petri, Kathleen E. Sullivan   +8 more
doaj   +1 more source

Neural markers of methylphenidate response in children with attention deficit hyperactivity disorder and the impact on executive function

Frontiers in Psychiatry
BackgroundAttention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity.
Anqi Wang, Anqi Wang, Hua Yang, Hua Yang, Yue Yang, Yue Yang, Jie Yang, Jie Yang, Xiaowen Yang, Xiaowen Yang, Qianhui Wen, Qianhui Wen, Qian Wang, Qian Wang, Hao Liu, Hao Liu, Rong Luo, Rong Luo   +17 more
doaj   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source