Results 111 to 120 of about 71,455 (301)

Tax physically associates with the ERα-CBP/p300 complex through binding to the recruited CBP/p300.

, 2014
(A) Schematical model 1 describing the formation of separate ERα-p300/CBP and Tax- p300/CBP complexes in E2 treated breast cells with or without Tax expression.
Mahmoud Huleihel (334022), Meital Shukrun (526178), Azhar Jabareen (526179), Mordechai Aboud (334024), Ammar Abou-Kandil (334020), Rachel Chamias (334021)   +5 more
core   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Effect of Psychostimulants on Distinct Attentional Parameters in Attentional Deficit/Hyperactivity Disorder

Biological Research, 2004
Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different ...
JAVIER LÓPEZ, VLADIMIR LÓPEZ, DANIEL ROJAS, XIMENA CARRASCO, PAULA ROTHHAMMER, RICARDO GARCÍA, FRANCISCO ROTHHAMMER, FRANCISCO ABOITIZ   +7 more
doaj  

P300 Control Matrix: A Novel Approach to P300 Speller Matrix

, 2018
Over the years, researchers have been able to prove Brain Computer Interface (BCI) -P300 Speller as an effective communication tool. The first P300 speller was developed by Farwell and Donchin (1988), using the oddball paradigm to evoke a P300 response ...
Odelade, Mobolaji
core  

p300 overexpression increased MMP-1 promoter activity.

, 2013
A, Schematic structure of MMP-1 promoter constructs. B, HDFs were transiently transfected with a series of 5′ deletion hMMP1/luciferase reporter plasmids (MMP1-1959luc, MMP1-939luc, and MMP1-207luc) together with 200 ng of pCMV-wt-p300 plasmid or pCMV ...
Jung-Min Shin (373832), Min-Kyoung Kim (373831), Jin Ho Chung (373834), Hee Chul Eun (104476)   +3 more
core   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

PBA2, a novel inhibitor of the β-catenin/CBP pathway, eradicates chronic myeloid leukemia including BCR-ABL T315I mutation

Molecular Cancer
Background BCR-ABL is a constitutively active tyrosine kinase that stimulates multiple downstream signaling pathways to promote the survival and proliferation of chronic myeloid leukemia (CML) cells.
Ke Yang, Kai Fu, Hong Zhang, Xiaokun Wang, Kenneth K.W. To, Caibo Yang, Fang Wang, Zhe-Sheng Chen, Liwu Fu   +8 more
doaj   +1 more source

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

, 2014
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Wang, Jian, Pestell, RG0, Fuqua, Suzanne A W, Wang, Chenguang, Yeung, YG, Hopp, Torsten, Jaffray, E, Chang, Chawnshang, Fu, Maofu, Sakamaki, Toshiyuki, Janne, OA, Zhang, Xueping, Hay, Ronald Thomas, Palvimo, Jorma J   +13 more
core   +1 more source

NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury

Journal of Diabetes Investigation, EarlyView.
In diabetic kidney disease (DKD), the acetyltransferase NAA10 mediates the acetylation of CREBRF, promoting its recognition and binding by the E3 ubiquitin ligase BTRC, thereby enhancing the ubiquitination level of CREBRF and accelerating its degradation.
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen   +3 more
wiley   +1 more source

PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome

Biology Direct
Background Prior research has highlighted the involvement of a transcriptional complex comprising C-terminal binding protein 2 (CtBP2), histone acetyltransferase p300, and nuclear factor kappa B (NF-κB) in the transactivation of proinflammatory cytokine ...
Fan Li, Wenqing Yan, Weihua Dong, Zhiping Chen, Zhi Chen   +4 more
doaj   +1 more source