Results 101 to 110 of about 121,215 (251)

Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia

Clinical Genetics, EarlyView.
Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise, Benkirane‐Jessel Nadia, Anton Nicolas, Vandamme Thierry, Clauss François, Conzatti Guillaume   +5 more
wiley   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

An Unsupervised Feature Extraction Method based on CLSTM-AE for Accurate P300 Classification in Brain-Computer Interface Systems [PDF]

Journal of Biomedical Physics and Engineering
Background: The P300 signal, an endogenous component of event-related potentials, is extracted from an electroencephalography signal and employed in Brain-computer Interface (BCI) devices.Objective: The current study aimed to address challenges in ...
Ramin Afrah, Zahra Amini, Rahele Kafieh
doaj   +1 more source

Lactate‐Induced Liquid–Liquid Phase Separation of HIF‐1α Drives Myeloid Cell Polarization and Immune Evasion in Colorectal Cancer

Cell Proliferation, EarlyView.
Lactate‐Induced Liquid‐Liquid Phase Separation of HIF‐1α Drives Myeloid Cell Polarization and Immune Evasion in Colorectal Cancer.
Chenhao Fu, Xiang Chen, Haoyu Huang, Lipeng Zhang, Haonan Huang, Fan Jiang, Fayang Lei, Honglong Yu, Jibiao Liu, Houping Zhang, Kan Dai, Zhixiong Wu, Huizi Li, Xi‐jian Dai, Shengxun Mao   +14 more
wiley   +1 more source

Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila

The FEBS Journal, EarlyView.
The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause, Marco Borsò, Marisa Müller, Axel Imhof, Zivkos Apostolou, Peter B. Becker   +5 more
wiley   +1 more source

Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus

Journal of Integrative Neuroscience
Background: The study investigated the neural correlates of mind wandering using eyeblink rate (EBR) and variability (EBV) proxies. Dopamine, a neurotransmitter integral to the brain’s reward system, has been implicated in regulating ...
Leigh M. Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood   +6 more
doaj   +1 more source

A change in the parameters of P300 evoked potentials in relation to the degree of exacerbation of pain syndrome

Неврология, нейропсихиатрия, психосоматика, 2012
In chronic pain, the state of suprasegmental brain structures (the cortex, limbic system, truncodiencephalic structures, which form the motivational-affective and cognitive components of pain behavior), actively affects pain afferentation as well.
A P Rachin, A A Averchenkova
doaj   +1 more source

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

The FEBS Journal, EarlyView.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek, Miroslava Vosahlikova, Zsofia Kutil, Zora Novakova, Julia Kudlacova, Ruzena Tuckova, Marat Meleshin, Barbora Havlinova, Pavlina Jaklova, Jana Ptackova, Cordelia Schiene‐Fischer, Mike Schutkowski, Cyril Barinka   +12 more
wiley   +1 more source

Proposal of a P300-based BCI Speller using a predictive Text system [PDF]

, 2013
This paper presents a P300-based BCI speller system that uses a virtual 4 x 3 keyboard based on the T9 interface developed on mobile phones in order to increase the writing speed. To validate the effectiveness of the proposed BCI, we compared it with two
Da Silva-Sauer, Leandro, Ron-Angevin, Ricardo   +1 more
core   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source