Results 81 to 90 of about 77,303 (286)

P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions

, 2023
Patients with cognitive deficits have a prolonged latency and reduced amplitude of the P300 wave. However, no study has correlated P300 wave alterations with the cognitive performance of patients with cerebellar lesions.
Misra, Amar Kumar, Nanda, Sourav, Kumar Misra, Amar, Ghosh, Sinjan, Manna, Akash, Lapeña Motilva, José, Benito León, Julián, Lapena-Motilva, Jose, Roy, Soumit, Benito-Leon, Julian, Guha, Gautam   +10 more
core   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Assessment of the operative memory capacity based on endogenous evoked potentials (P300 method) without neuropsychological testing

Анналы клинической и экспериментальной неврологии, 2017
We analyzed the dependence of the operative memory (OP) capacityon P300 parameters in healthy individuals and patientswith a varying degree of memory impairments.
V. V. Gnezditskiy, A. V. Chatskaya, O. S. Korepina, O. I. Klochkova   +3 more
doaj   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Change of P300 in Elderly Diabetes and Related Factors

, 2001
目的 :了解老年糖尿病人P300认知电位的改变及与病程、糖代谢及并发症的关系。方法 :采用听觉oddball序列刺激的诱发电位方法对 50例老年糖尿病人及 20例健康老年人进行测试。结果 :糖尿病组与对照组比较 ,糖尿病并腔隙性脑梗塞组与无脑梗塞组比较P300波潜伏期显著延长 ,P300波波幅显著降低 ,糖尿病组P300波潜伏期和波幅与病程长短、糖化血红蛋白及有无高血压病无明显相关。结论 :老年糖尿病人比正常老年人P300波潜伏期明显延长 ,P300波波幅明显降低 ...
姜涛, 张雄伟, 吴振云
core   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

An Unsupervised Feature Extraction Method based on CLSTM-AE for Accurate P300 Classification in Brain-Computer Interface Systems [PDF]

Journal of Biomedical Physics and Engineering
Background: The P300 signal, an endogenous component of event-related potentials, is extracted from an electroencephalography signal and employed in Brain-computer Interface (BCI) devices.Objective: The current study aimed to address challenges in ...
Ramin Afrah, Zahra Amini, Rahele Kafieh
doaj   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Cognitive Dysfunction in Chronic Rhinosinusitis: A Scoping Review

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Cognitive dysfunction is increasingly recognized as an extra‐nasal manifestation of chronic rhinosinusitis (CRS). This scoping review characterizes the primary evidence on cognition in adult CRS, covering measures, treatment response, and incident dementia.
Luke M. O'Neil, Hannan A Qureshi, Logan Lindemann, David J. Cvancara, Ashton E. Lehmann, Aria Jafari   +5 more
wiley   +1 more source

Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus

Journal of Integrative Neuroscience
Background: The study investigated the neural correlates of mind wandering using eyeblink rate (EBR) and variability (EBV) proxies. Dopamine, a neurotransmitter integral to the brain’s reward system, has been implicated in regulating ...
Leigh M. Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood   +6 more
doaj   +1 more source