Results 91 to 100 of about 71,455 (301)

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

An Unsupervised Feature Extraction Method based on CLSTM-AE for Accurate P300 Classification in Brain-Computer Interface Systems [PDF]

Journal of Biomedical Physics and Engineering
Background: The P300 signal, an endogenous component of event-related potentials, is extracted from an electroencephalography signal and employed in Brain-computer Interface (BCI) devices.Objective: The current study aimed to address challenges in ...
Ramin Afrah, Zahra Amini, Rahele Kafieh
doaj   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Transcriptional regulation mediated through the conjugation and deconjugation of the small ubiquitin-like modifiers SUMO-1, SUMO-2, and SUMO-3

, 2012
SUMO-1/2/3 are members of the ubiquitin-like family of protein modifiers. These proteins are covalently attached to numerous proteins in a directed and controlled manner.
Girdwood, David William Haxton
core  

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus

Journal of Integrative Neuroscience
Background: The study investigated the neural correlates of mind wandering using eyeblink rate (EBR) and variability (EBV) proxies. Dopamine, a neurotransmitter integral to the brain’s reward system, has been implicated in regulating ...
Leigh M. Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood   +6 more
doaj   +1 more source

A change in the parameters of P300 evoked potentials in relation to the degree of exacerbation of pain syndrome

Неврология, нейропсихиатрия, психосоматика, 2012
In chronic pain, the state of suprasegmental brain structures (the cortex, limbic system, truncodiencephalic structures, which form the motivational-affective and cognitive components of pain behavior), actively affects pain afferentation as well.
A P Rachin, A A Averchenkova
doaj   +1 more source

KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2‐Dependent MDSC Recruitment

Cancer Science, EarlyView.
KPNA2 drives intratumoral MDSC accumulation and immunosuppression in ovarian cancer via the NF‐κB/CCL2/CCR2 axis. Mechanistically, KPNA2 facilitates NF‐κB/p65 nuclear translocation and induces CCL2 transcription, recruiting MDSCs to establish an immunosuppressive microenvironment.
Qingli Li, Jitong Zhao, Lu Yang, Lin Li, Ce Bian, Tao Yi, Huiqiong Huang, Gang Zheng, Xiaojuan Lin   +8 more
wiley   +1 more source

Change of P300 in Elderly Diabetes and Related Factors

, 2001
目的 :了解老年糖尿病人P300认知电位的改变及与病程、糖代谢及并发症的关系。方法 :采用听觉oddball序列刺激的诱发电位方法对 50例老年糖尿病人及 20例健康老年人进行测试。结果 :糖尿病组与对照组比较 ,糖尿病并腔隙性脑梗塞组与无脑梗塞组比较P300波潜伏期显著延长 ,P300波波幅显著降低 ,糖尿病组P300波潜伏期和波幅与病程长短、糖化血红蛋白及有无高血压病无明显相关。结论 :老年糖尿病人比正常老年人P300波潜伏期明显延长 ,P300波波幅明显降低 ...
姜涛, 张雄伟, 吴振云
core  

DUSP4 regulates p300 phosphorylation status.

, 2016
Confocal laser scanning microscopy was performed on either MDA-MB-231 cells or MCF-7 cells treated with vehicle alone or PMA for 60 h (MCF-7/PMAAD or MCF-7/PMASUS cells) and subsequently transfected with either MOCK siRNA or DUSP4 siRNA. Cells were fixed
Wenjuan Tu (848867), Sudha Rao (6651), Kristine Hardy (25161), Desmond Yip (57134), Amanda Bullman (848868), Jane E. Dahlstrom (848869), Robert McCuaig (443015), Tara Boulding (848864), Fan Wu (43375), Christopher R. Sutton (848866), Jennifer Dunn (848865)   +10 more
core   +1 more source