Results 161 to 170 of about 55,117 (228)

Apolipoprotein E Deficiency Impairs Human Microglial Proliferation Accompanied by Elevated Cellular Oxidative Stress

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT The APOE gene, which encodes Apolipoprotein E (ApoE), is the strongest genetic risk locus for Alzheimer's disease (AD). A substantial fraction of AD risk genes converges on pathways controlling lipid metabolism and immune regulation, in which microglia serve as a central integrative hub in the brain.
Dayoung Kim   +6 more
wiley   +1 more source

Are Fear Learning Processes Altered in Obsessive‐Compulsive Disorder, Social Anxiety, and Specific Phobia? Insights From the Late Positive Potential, Fear‐Potentiated Startle, and Ratings

open access: yesPsychophysiology, Volume 63, Issue 3, March 2026.
ABSTRACT Fear learning processes are often considered underlying mechanisms in the development and maintenance of anxiety‐ and stress‐related disorders. However, limited attention has been paid to whether these changes are shared across disorders or certain symptoms. In this context, transdiagnostic research on symptom dimensions is especially relevant,
Kim M. Sobania   +5 more
wiley   +1 more source

Runx2 Regulated Airway Homeostasis Is Disrupted in Asthma

open access: yesThe FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Runt‐related transcription factor‐2 (RUNX2) expression and regulation of airway remodeling factors were examined in asthmatic and nonasthmatic airway smooth muscle (ASM) cells. Regulation by transforming growth factor‐β of active RUNX2 isoform translocation to the nucleus was absent in asthmatic ASM, while RUNX2 overexpression suppressed markers of ...
Junfei Wang   +13 more
wiley   +1 more source

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