Results 181 to 190 of about 154,769 (339)

Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Executive dysfunction in Huntington's disease follows a selective, stage‐dependent pattern, with early deficits in psychomotor speed, cognitive flexibility, inhibition, and working‐memory updating. Progression is associated with broader impairments in planning and attention.
Simone Migliore   +4 more
wiley   +1 more source

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

open access: yesClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu   +5 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

open access: yesInternational Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao   +6 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Non-Verbal and Verbal P300 of Auditory and Visual Stimuli. (1st Report).

open access: diamond, 1997
Taeko ITOH   +5 more
openalex   +2 more sources

Pan‐Epigenetic Age Prediction in Mammals

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Across > 1000 human and mouse epigenomes, histone modifications and DNA methylation undergo coordinated, cross‐tissue remodeling at shared genes. ABSTRACT Epigenetic remodeling is a hallmark of aging, yet which epigenetic layers are most affected during aging—and the extent to which they are interrelated—is not well understood.
Zane Koch, Adam Li, Trey Ideker
wiley   +1 more source

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