Results 201 to 210 of about 71,455 (301)

A Feedback Loop Driven by H3K18la and ASF1B via the LINC02732-miR-1291 Axis Promotes Hepatocellular Carcinoma Proliferation. [PDF]

Cells
Yu J, Xin L, Cui Y, Fan C, Yang Y, Zhang X.   +5 more
europepmc   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

P300-mediated H3K18 acetylation triggers necroptosis via modulation of KRT18 transcription in diabetic nephropathy. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Zhao Q, Cai Q, Nizam A, Yang Q, Liu X, Meng F, Meng Z.   +6 more
europepmc   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

CBP/p300 is critical for the expansion and maintenance of functional pancreatic α cell mass. [PDF]

Nat Commun
Wang S, Li T, Sheng C, Tan J, Yang Y, Ma X, Liu Y, Wei R, Zhou F, Zhou L, Wang X.   +10 more
europepmc   +1 more source

Effects of Exercise on Cancer‐Related Cognitive Impairment: An Umbrella Review of Systematic Reviews and Meta‐Analysis

Psycho-Oncology, Volume 35, Issue 6, June 2026.
ABSTRACT Background Cancer‐related cognitive impairment (CRCI) is a common consequence of cancer and its treatments, with mild but significant deficits in memory, attention or executive function. These symptoms negatively affect survivors' quality of life, daily functioning, and return to work.
Francisco Gómez‐Almeida, Daniel González‐Devesa, Clara Gacparski, Cristina Nombela, Oscar L. Veiga   +4 more
wiley   +1 more source

Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infection. [PDF]

iScience
Sui L, Zhao YH, Wang H, Chi H, Xie H, Tian T, Wang W, Zhu M, Zhai N, Song Z, Xu Y, Zhang K, Che L, Wang G, Liu N, Zhao Y, Liu Q.   +16 more
europepmc   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, Volume 7, Issue 3, June 2026.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Case Report: post-stroke rehabilitation with a visuomotor transformation-based brain-computer interface. [PDF]

Front Hum Neurosci
Kokorina A, Syrov N, Yakovlev L, Lebedev M.   +3 more
europepmc   +1 more source

Discovery of a Novel γ‐Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence‐Based High‐Throughput Screening

Cancer Science, Volume 117, Issue 6, Page 1713-1723, June 2026.
A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi, Yukie Nohara, Mano Horinaka, Kozue Nose, Masaya Mori, Hiromi Ii, Hiroko Kawakami, Kazuto Yano, Susumu Nakata, Taku Yoshiya, Toshiyuki Sakai   +10 more
wiley   +1 more source