Results 211 to 220 of about 154,769 (339)

The WTX Tumor Suppressor Enhances p53 Acetylation by CBP/p300 [PDF]

open access: bronze, 2012
Woo‐Jae Kim   +3 more
openalex   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

open access: yesInternational Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano   +6 more
wiley   +1 more source

Suicide Risk Estimation in Bipolar Disorder Using N200 and P300 Event-related Potentials and Machine Learning: A Pilot Study

open access: green
Chaewon Lee   +6 more
openalex   +1 more source

Mechanisms of enhancer‐driven oncogene activation

open access: yesInternational Journal of Cancer, Volume 158, Issue 2, Page 333-341, 15 January 2026.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend   +2 more
wiley   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

open access: yesInternational Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum   +2 more
wiley   +1 more source

A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao   +9 more
wiley   +1 more source

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