Results 51 to 60 of about 71,455 (301)

p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

eLife, 2014
Deregulated expression of COX-2 has been causally linked to development, progression, and outcome of several types of human cancer. We describe a novel fundamental level of transcriptional control of COX-2 expression.
Michal Krawczyk, Beverly M Emerson
doaj   +1 more source

The relationship between Hippocampal asymmetry and working memory processing in combat-related PTSD: a monozygotic twin study

, 2012
BACKGROUND: PTSD is associated with reduction in hippocampal volume and abnormalities in hippocampal function. Hippocampal asymmetry has received less attention, but potentially could indicate lateralised differences in vulnerability to trauma.
McFarlane, Alexander, Veltmeyer, Melinda, Hall, T., Metzger, L., Melinda Veltmeyer, Gilbertson, Mark, Orr, Scott, Gilbertson, M., Linda J Metzger, Galletly, C., Roger K Pitman, Pitman, Roger, Cherrie Galletly, Clark, C Richard, Veltmeyer, M., Orr, S., Clark, C., Alexander McFarlane, McFarlane, A., C Clark, Pitman, R., Timothy Hall, Hall, Timothy, Scott P Orr, Metzger, Linda J, Mark W Gilbertson, Galletly, Cherrie   +26 more
core   +1 more source

Individual functions of the histone acetyl transferases CBP and p300 in regulating the inflammatory response of synovial fibroblasts [PDF]

, 2021
Chromatin remodeling, and a persistent histone 3 lysine 27 acetylation (H3K27ac) in particular, are associated with a sustained inflammatory response of synovial fibroblasts (SF) in rheumatoid arthritis (RA).
Maciukiewicz, Malgorzata, Matija Tomšič, Moser, Larissa, Gabathuler, Marcel, Marks, Miriam, Miriam Marks, Distler, Oliver; https://orcid.org/, Klein, Kerstin, Malgorzata Maciukiewicz, Distler, Oliver, Lee, Gideon Isaac, Larissa Moser, Marcel Gabathuler, Monika Krošel, Tomšič, Matija, Kerstin Klein, Ospelt, Caroline, Ospelt, Caroline; https://orcid.org/, Gideon Isaac Lee, Krošel, Monika, Caroline Ospelt, Oliver Distler   +21 more
core   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

An analysis of the accuracy of the P300 BCI [PDF]

Brain-Computer Interfaces, 2018
The P300 Brain-Computer Interface (BCI) is a well-established communication channel for severely disabled people. The P300 event-related potential is mostly characterized by its amplitude or its area, which correlate with the spelling accuracy of the P300 speller.
Nitzan S. Artzi, Oren Shriki
openaire   +2 more sources

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

p300 upregulates Ikur in atrial cardiomyocytes through activating NLRP3 inflammasome in hypertension

Chinese Medical Journal
. Background:. The nucleotide-binding oligomerization domain [NOD-], leucine-rich repeats [LRR-], and Pyrin domain-containing protein 3 (NLRP3) inflammasome plays an essential role in hypertension-related atrial fibrillation (AF).
Long Zeng, Panyue Liu, Fang Rao, Zhimin Du, Haiyin Xiao, Shenghuan Yu, Chunyu Deng, Mengzhen Zhang, Fangzhou Liu, Rui Zhu, Hai Deng, Shulin Wu, Yumei Xue, Xianhong Fang, Wei Wei, Xiangxiang Pan   +15 more
doaj   +1 more source

Effects of Sleep Deprivation on Visual P300 [PDF]

, 2006
睡眠剥夺在日常生活工作中广泛存在,导致认知功能下降,其中警觉水平下降最为明显。实验采用Oddball范式辨别任务,研究了32名青年男性在不同睡眠剥夺条件(sleep deprivation,SD)下(SD21h、SD45h、SD69h、正常对照组)的事件相关电位(event-related potentials,ERPs)P300成分的变化。结果表明,随SD时间延长,P300波幅降低、潜伏期延长 ...
宋国萍, 苗丹民, 赵仑, 皇甫恩
core  

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Potencial evocado cognitivo e desordem de processamento auditivo em crianças com distúrbios de leitura e escrita Cognitive evoked potentials and central auditory processing in children with reading and writing disorders

Brazilian Journal of Otorhinolaryngology, 2012
As dificuldades na aprendizagem escolar muitas vezes podem ser causadas por uma alteração do Processamento Auditivo - PA. OBJETIVO: Identificar se acima da média dos valores de latência do P300, num grupo de indivíduos com Distúrbio de Leitura e Escrita,
Gislaine Richter Minhoto Wiemes, Lorena Kozlowski, Marcos Mocellin, Rogério Hamerschmidt, Luiz Henrique Schuch   +4 more
doaj   +1 more source