Results 41 to 50 of about 77,303 (286)
EBioMedicineSummary: Background: The E1A-associated protein p300 (p300) has emerged as a promising target for cancer therapy due to its crucial role in promoting oncogenic signaling pathways in various cancers, including prostate cancer.
Dize Zhang +14 more
doaj +1 more source
Oncogene, 2004 p300 and cyclic AMP response element-binding protein (CBP) are adenoviral E1A-binding proteins involved in multiple cellular processes, and function as transcriptional co-factors and histone acetyltransferases. Germline mutation of CBP results in Rubinstein-Taybi syndrome, which is characterized by an increased predisposition to childhood malignancies.
Narayanan Gopalakrishna, Iyer +2 more
openaire +2 more sources
Incorporation of a language model into a Brain Computer Interface based speller through HMMs [PDF]
, 2012 Brain computer interface (BCI) research deals with the problem of establishing direct communication pathways between the brain and external devices. The primary motivation is to enable patients with limited or no muscular control to use external devices ...
Çetin, Müjdat +3 more
core +1 more source
Brazilian Journal of Otorhinolaryngology, 2011 A Síndrome da Apneia Obstrutiva do Sono (SAOS) diminui as capacidades da atenção, memória e concentração, fatores relacionados com a cognição. A análise dos parâmetros do P300 auditivo permitiria inferir disfunção cognitiva.
Carlos Henrique Martins +3 more
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL
Frontiers in Oncology, 2019 T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch signaling.
Luca Tottone +14 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
eLife, 2014 Deregulated expression of COX-2 has been causally linked to development, progression, and outcome of several types of human cancer. We describe a novel fundamental level of transcriptional control of COX-2 expression.
Michal Krawczyk, Beverly M Emerson
doaj +1 more source
The Wisconsin card sorting test performance and the P300 of event-related potentials in schizophrenia [PDF]
, 2003 Both a poor performance on the Wisconsin Card Sorting Test (WCST) and abnormalities in P300 are the most frequently replicated biological findings in schizophrenic patients.
Iwanami, Akira, Koyama, Akio
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source