Results 41 to 50 of about 121,215 (251)

Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapyResearch in context

EBioMedicine
Summary: Background: The E1A-associated protein p300 (p300) has emerged as a promising target for cancer therapy due to its crucial role in promoting oncogenic signaling pathways in various cancers, including prostate cancer.
Dize Zhang, Bohan Ma, Donghua Liu, Wei Wu, Tianyang Zhou, Yibo Gao, Cunli Yang, Yanlin Jian, Yizeng Fan, Yuchen Qian, Jian Ma, Yang Gao, Yule Chen, Shan Xu, Lei Li   +14 more
doaj   +1 more source

p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1).

PLoS ONE, 2010
Backgroundp300 functions as a transcriptional co-activator to regulate many cellular responses such as cell growth, transformation, development and differentiation.
Ping-Pui Wong, Adam Pickard, Dennis J McCance   +2 more
doaj   +1 more source

Motivational salience modulates early visual cortex responses across task sets [PDF]

, 2017
Motivationally relevant stimuli benefit from strengthened sensory processing. It is unclear, however, if motivational value of positive and negative valence has similar or dissociable effects on early visual processing. Moreover, whether these perceptual
Bayer, Mareike, Grass, Annika, Pourtois, Gilles, Rossi, Valentina, Schacht, Annekathrin, Vanlessen, Naomi   +5 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Síndrome da apneia obstrutiva do sono e o potencial auditivo P300 Obstructive sleep apnea and P300 evoked auditory potential

Brazilian Journal of Otorhinolaryngology, 2011
A Síndrome da Apneia Obstrutiva do Sono (SAOS) diminui as capacidades da atenção, memória e concentração, fatores relacionados com a cognição. A análise dos parâmetros do P300 auditivo permitiria inferir disfunção cognitiva.
Carlos Henrique Martins, Ney de Castro Júnior, Orozimbo Alves Costa Filho, Osmar Mesquita de Souza Neto   +3 more
doaj   +1 more source

Cigarette smoke extract induces the senescence of endothelial progenitor cells by upregulating p300

Tobacco Induced Diseases, 2023
Introduction Endothelial progenitor cells (EPCs) are the main source of endothelial cells. The senescence of EPCs is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Guibin Liang, Zhihui He, Huaihuai Peng, Menghao Zeng, Xuefeng Zhang   +4 more
doaj   +1 more source

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function [PDF]

, 2002
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Chang, Chawnshang, Fu, Maofu, Fuqua, Suzanne A W, Hay, Ronald Thomas, Hopp, Torsten, Jaffray, E, Janne, OA, Palvimo, Jorma J, Pestell, RG0, Sakamaki, Toshiyuki, Wang, Chenguang, Wang, Jian, Yeung, YG, Zhang, Xueping   +13 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Atypical neural responses to vocal anger in attention-deficit/hyperactivity disorder [PDF]

, 2014
Background Deficits in facial emotion processing, reported in attention-deficit/hyperactivity disorder (ADHD), have been linked to both early perceptual and later attentional components of event-related potentials (ERPs).
Banaschewski, Banaschewski, Banse, Barry, Biederman, Blackburn, Bostanov, Broyd, Bruckmann, Chronaki, Chronaki, Corbett, Corwin, Cullum, D'Agati, Dennis, Dien, Eimer, Fairchild, Goodman, Hogan, Ibáñez, Iredale, Jaaskelainen, Johnston, Johnstone, Johnstone, Johnstone, Konrad, Korpilahti, Kosslyn, Köchel, Köchel, Loiselle, Maurage, Mueller, Nelson, Norvilitis, Oades, Olincy, Pang, Pinheiro, Pinheiro, Putman, Sander, Schirmer, Semlitsch, Shaffer, Shapiro, Shaw, Sonuga-Barke, Stringaris, Toivonen, Uekermann, Wechsler, Williams, Woldorff, Woodman, Wunderlich, Zambelli   +59 more
core   +2 more sources

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source